3 withdrawn, 2 completed, 2 terminated. 6 Phase 1, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 2, Terminated 2, Withdrawn 2 |
| Early Phase 1 | 1 | Withdrawn 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Alpelisib in Combination With Carboplatin in Patients With Solid Tumors and HPV-Positive Squamous Cell Carcinoma Alpelisib, Carboplatin, Hyperpolarized Carbon-13 (13C) Pyruvate - Solid Tumors, Adult, PIK3CA Mutation-Related Tumors | Phase 1 | Withdrawn | Pamela Munster | 2022-11-01 | 2022-12-27 | |
| Abexinostat, Palbociclib, and Fulvestrant for the Treatment of Breast or Gynecologic Cancer Abexinostat Tosylate, Fulvestrant, Palbociclib - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 1 | Withdrawn | Pamela Munster | 2021-03-31 | 2021-05-18 | |
| Rucaparib and Irinotecan in Cancers With Mutations in DNA Repair Rucaparib, Irinotecan - Solid Tumor, Unspecified, Adult | Phase 1 | Completed | Pamela Munster | 22 | 2018-01-12 | 2021-03-04 |
| Phase Ib Study of Alpelisib With Cisplatin in Patients With HPV+ Solid Tumor Malignancies Alpelisib, Cisplatin - Solid Tumors | Phase 1 | Terminated | Pamela Munster | 28 | 2016-12-01 | 2020-01-10 |
| 64-Cu Labeled Brain PET/MRI for MM-302 in Advanced HER2+ Cancers With Brain Mets MM-302, Trastuzumab - Brain Metastases, Documented Her2 Overexpression | Early Phase 1 | Withdrawn | Pamela Munster | 2016-04-01 | 2017-05-04 | |
| Study of BMN-673 With Carboplatin and Paclitaxel in Patients With Advanced BRCA-mutated Solid Tumor or Triple Negative Metastatic Breast Cancer BMN-673, Carboplatin, Paclitaxel - Triple Negative Metastatic Breast Cancer, BRCA-mutated Solid Tumor | Phase 1 | Terminated | Pamela Munster | 23 | 2015-02-23 | 2020-01-10 |
| Pazopanib in Combination With PCI-24781 in Patients With Metastatic Solid Tumors PZP115891, PCI-24781 - Metastatic Solid Tumors | Phase 1 | Completed | Pamela Munster | 90 | 2012-06-25 | 2025-03-21 |
Neoplasm Metastasis (4) · Brain Neoplasms (1) · Breast Neoplasms (1) · Carcinoma, Endometrioid (1) · Disease Progression (1) · Fallopian Tube Neoplasms (1) · Ovarian Neoplasms (1) · Sarcoma (1)
Alpelisib (2) · Carboplatin (2) · Cisplatin (1) · Fulvestrant (1) · Irinotecan (1) · Paclitaxel (1) · Pyruvic Acid (1) · Trastuzumab (1) · abexinostat (1) · gancotamab (1) · palbociclib (1) · pazopanib (1) · rucaparib (1) · talazoparib (1)
United States (4)