4 completed, 4 terminated, 3 active not recruiting, 2 recruiting. 9 Phase 1, 7 Phase 2, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 3, Terminated 3, Recruiting 2, Active not recruiting 1 |
| Phase 2 | 7 | Active not recruiting 3, Terminated 2, Completed 1, Recruiting 1 |
| Early Phase 1 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Imaging of Solid Tumors Using 18F-TRX 18F-TRX, Positron Emission Tomography (PET)/Computerized tomography (CT), Tumor Biopsy - Solid Tumor, Solid Carcinoma | Phase 1 | Recruiting | Rahul Aggarwal | 56 | 2025-07-03 | 2026-07-23 |
| 64Cu-GRIP B in Patients With Advanced Malignancies Copper-64 labeled Granzyme B (64Cu-GRIP B), Positron Emission Tomography (PET) - Prostate Cancer, Renal Cancer | Phase 1 / Phase 2 | Recruiting | Rahul Aggarwal | 91 | 2023-05-25 | 2026-03-17 |
| Apalutamide Plus Cetrelimab in Patients With Treatment-Emergent Small Cell Neuroendocrine Prostate Cancer Apalutamide, Cetrelimab - Small Cell Neuroendocrine Carcinoma, Prostate Cancer | Phase 2 | Terminated | Rahul Aggarwal | 2 | 2022-03-16 | 2025-05-15 |
| FOR46 in Combination With Enzalutamide in Patients With Metastatic Castration Resistant Prostate Cancer FOR46, Enzalutamide, Pegfilgrastim - Metastatic Castration-resistant Prostate Cancer, Prostate Cancer | Phase 1 / Phase 2 | Active not recruiting | Rahul Aggarwal | 44 | 2022-01-19 | 2026-09-17 |
| 11C-YJH08 PET Imaging for Detection of Glucocorticoid Receptor Expression Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 1 | Terminated | Rahul Aggarwal | 2 | 2021-08-10 | 2025-05-20 |
| ZEN-3694, Enzalutamide, and Pembrolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer BET Bromodomain Inhibitor ZEN-3694, Enzalutamide, Pembrolizumab - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma | Phase 2 | Active not recruiting | Rahul Aggarwal | 61 | 2021-01-26 | 2026-07-23 |
| Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors Ceralasertib, Olaparib, Durvalumab - Clear Cell Renal Cell Carcinoma, Locally Advanced Pancreatic Cancer | Phase 2 | Active not recruiting | Rahul Aggarwal | 83 | 2019-01-17 | 2026-04-23 |
| Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignancies Abexinostat, Pembrolizumab - Stage III Cutaneous Melanoma, Stage IV Cutaneous Melanoma | Phase 1 | Completed | Rahul Aggarwal | 35 | 2018-08-20 | 2024-03-22 |
| Magnetic Resonance (MR) Imaging With Hyperpolarized Pyruvate (HP) (13C) in Castration-Resistant Prostate Cancer Pyruvate (13C), MRI - Prostate Cancer | Phase 1 | Terminated | Rahul Aggarwal | 8 | 2016-11-08 | 2020-07-24 |
| Hyperpolarized C-13 Pyruvate as a Biomarker in Patients With Advanced Solid Tumor Malignancies Pyruvate (13C), MRI - Prostate Cancer | Phase 1 / Phase 2 | Terminated | Rahul Aggarwal | 23 | 2016-10-20 | 2022-04-22 |
| LEE011 (Ribociclib) in Combination With Docetaxel Plus Prednisone in mCRPC Docetaxel-PNP, Ribociclib, Prednisone - Prostate Cancer | Phase 1 / Phase 2 | Completed | Rahul Aggarwal | 43 | 2015-11-20 | 2022-08-31 |
| Gallium-68 Citrate PET Used in Prostate Cancer Gallium-68 citrate, Positron Emission Tomography (PET) - Prostatic Neoplasms | Early Phase 1 | Completed | Rahul Aggarwal | 39 | 2015-05-28 | 2023-06-18 |
| Phase I Cabazitaxel, Mitoxantrone, and Prednisone Metastatic Castration-Resistant Prostate Cancer Cabazitaxel, Mitoxantrone, Prednisone - Metastatic Castration-resistant Prostate Cancer | Phase 1 | Completed | Rahul Aggarwal | 25 | 2012-06-01 | 2017-07-21 |
Prostatic Neoplasms (10) · Neoplasm Metastasis (6) · Carcinoma, Renal Cell (2) · Carcinoma, Transitional Cell (2) · Bulbo-Spinal Atrophy, X-Linked (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Small Cell (1) · Clear-cell metastatic renal cell carcinoma (1) · Endometrial Neoplasms (1) · Glioma (1) · Kidney Neoplasms (1) · Lipodystrophy, Congenital Generalized (1) · Lung Neoplasms (1) · Melanoma (1) · Pancreatic Neoplasms (1)
Magnetic Resonance Spectroscopy (4) · Blood Specimen Collection (2) · Prednisone (2) · Pyruvic Acid (2) · enzalutamide (2) · pegfilgrastim (2) · pembrolizumab (2) · ADP Ribose Transferases (1) · Biopsy (1) · Citric Acid (1) · Docetaxel (1) · Filgrastim (1) · Gallium-68 (1) · Granulocyte Colony-Stimulating Factor (1) · Immunoconjugates (1)
United States (13)
R01CA166655 (1), R01CA183071 (1), R01CA229354 (1), R01CA258297 (1), R01MH115043 (1)