4 recruiting, 2 active not recruiting, 1 withdrawn. 3 Phase 1, 2 Phase 2, 1 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Active not recruiting 2, Withdrawn 1 |
| Phase 2 | 2 | Recruiting 2 |
| Not applicable | 1 | Recruiting 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Metastatic Malignant Neoplasm in the Leptomeninges: new trials by email Literature Review of Metastatic Malignant Neoplasm in the Leptomeninges trials Research Report on Metastatic Malignant Neoplasm in the Leptomeninges
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer Biospecimen Collection, Craniospinal Irradiation, Electronic Health Record Review - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 35 | 2025-05-05 | 2025-12-08 |
| Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial Biospecimen Collection, Computed Tomography, Involved-Field Radiation Therapy - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 3 | Recruiting | NRG Oncology | 115 | 2025-03-04 | 2026-08-17 |
| Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Recruiting | University of Washington | 22 | 2025-03-03 | 2026-08-14 |
| Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Breast Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 1 | Withdrawn | Northwestern University | 2023-12-31 | 2024-04-01 | |
| Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer Digital Photography, Lumbar Puncture, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Not applicable | Recruiting | Mayo Clinic | 5 | 2023-04-07 | 2026-04-02 |
| Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers Adavosertib, Radiation Therapy - Clinical Stage III Esophageal Adenocarcinoma AJCC v8, Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8 | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 4 | 2021-04-09 | 2026-07-31 |
| HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases Chimeric Antigen Receptor T-Cell Therapy - Malignant Neoplasm, Metastatic Malignant Neoplasm in the Brain | Phase 1 | Active not recruiting | City of Hope Medical Center | 24 | 2018-11-27 | 2026-08-12 |
Meningeal Carcinomatosis (7) · Breast Neoplasms (6) · Lung Neoplasms (4) · Brain Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (3) · Adenocarcinoma Of Esophagus (1) · Esophageal Squamous Cell Carcinoma (1) · Neoplasms (1)
Central Nervous System Neoplasms (7) · Meningeal Neoplasms (7) · Neoplasms by Site (7) · Nervous System Diseases (7) · Nervous System Neoplasms (7) · Breast Diseases (6) · Neoplasms (6) · Skin Diseases (6) · Skin and Connective Tissue Diseases (6) · Lung Diseases (4) · Respiratory Tract Diseases (4) · Respiratory Tract Neoplasms (4) · Thoracic Neoplasms (4) · Brain Diseases (3) · Bronchial Neoplasms (3)
Magnetic Resonance Spectroscopy (5) · Specimen Handling (5) · Spinal Puncture (4) · Radiation (2) · Radiotherapy (2) · Radiotherapy, Intensity-Modulated (2) · Craniospinal Irradiation (1) · Immunotherapy, Adoptive (1) · Physical Examination (1) · Vinorelbine (1) · adavosertib (1)
City of Hope Medical Center (2) · Mayo Clinic (1) · NRG Oncology (1) · National Cancer Institute (NCI) (1) · Northwestern University (1) · University of Washington (1)
United States (7)
Eric D Miller (1) · Jana L Portnow (1) · Jonathan T Yang (1) · Lia M. Halasz (1) · Roger Stupp, MD (1) · Stephanie M Yoon (1) · Wendy J. Sherman, MD (1)
P30CA033572 (1), P30CA060553 (1), U10CA180868 (1), UM1CA186712 (1)