18 completed, 5 recruiting, 5 unknown, 3 not yet recruiting. 30 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 30 | Completed 15, Recruiting 5, Unknown 4, Not yet recruiting 3, Enrolling by invitation 2, Active not recruiting 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Malocclusion, Angle Class I: new trials by email Literature Review of Malocclusion, Angle Class I trials Research Report on Malocclusion, Angle Class I
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 3D Printed Occlusal Splints for Intraoperative Use Formlabs 3D printed occlusal splint, Industry made occlusal splint - Malocclusion, Angle Class I, Malocclusion, Angle Class II | Not applicable | Not yet recruiting | Johns Hopkins University | 70 | 2026-12-30 | 2026-08-11 |
| Effect of Early Versus Late Premolar Extraction on Orthodontic Tooth Movement Early Maxillary First Premolar Extraction, Late Maxillary First Premolar Extraction - Malocclusion Class II, Malocclusion, Angle Class I | Not applicable | Recruiting | Shifa College of Dentistry | 26 | 2026-07-22 | 2026-08-19 |
| Clinical Performance of Direct-Printed Versus Thermoformed Aligners Direct-Printed Aligner, Thermoformed aligner - Angle Class I Malocclusion, Dental Crowding | Not applicable | Recruiting | University of Baghdad | 34 | 2026-06-01 | 2026-06-09 |
| Treatment Outcome of Elastomeric and Nickel-Titanium Separators in Tooth Separation Elastomeric separators, Nickel-Titanium separators - Dental Crowding, Malocclusion, Angle Class I | Not applicable | Not yet recruiting | 3D-Aligners | 30 | 2026-06-01 | 2026-05-15 |
| Nano Coated Orthodontic Miniscrews for en Mass Retraction of the Upper Arch Silver nanoparticles, uncoated titanium miniscrews - Class I Malocclusion, Maxillary Prognathism | Not applicable | Recruiting | Al-Azhar University | 14 | 2026-05-01 | 2026-04-13 |
| LLLLT vs Piezocision in Accelerating Orthodontic Canine Retraction Low Level Laser Therapy, Piezocision - Malocclusion, Angle Class II, Division 1, Bimaxillary Protrusion | Not applicable | Recruiting | Hesham Nabil Ali Al-Qamhawy | 21 | 2026-04-01 | 2026-05-11 |
| The Predictability of Directly Printed Versus Thermoformed Clear Aligners Direct-printed aligner (Graphy), Thermoformed aligner - Class I Malocclusion, Crowded Teeth | Not applicable | Enrolling by invitation | University of Baghdad | 36 | 2026-02-15 | 2026-04-15 |
| Antibiofilm Activity of Chitosan Nanoparticles Incorporated Into Clear Aligners Control (Standard treatment), Chitosan - Malocclusion, Angle Class I | Not applicable | Active not recruiting | University of Baghdad | 32 | 2025-01-25 | 2025-02-12 |
| Effect of Different Grafting Material Following Surgically Facilitated Orthodontics Therapy Surgically facilitated orthodontics therapy (SFOT) using allograft, Surgically facilitated orthodontics therapy (SFOT) using xenograft, Usual care - Malocclusion, Angle Class I | Not applicable | Not yet recruiting | The University of Texas Health Science Center, Houston | 24 | 2025-01-06 | 2024-10-04 |
| Assesment of Ethnic Bias in an Artificial Intelligence Based Orthodontic Diagnosis System Class I Malocclusion, Class II Div 1 Malocclusion | Completed | Bezmialem Vakif University | 10000 | 2025-01-06 | 2026-09-15 | |
| Micro-Osteoperforations to Accelerate Maxillary Canine Retraction in Class I Malocclusion Micro-osteoperforations (MOPs), Conventional Canine Retraction - Malocclusion, Angle Class I | Not applicable | Completed | Can Tho University of Medicine and Pharmacy | 40 | 2025-01-01 | 2025-09-04 |
| Microanalysis of Changes in 3D Geometry of Orthodontic Mini-implants Insertion, Scanning - Malocclusions, Malocclusion, Angle Class I | Active not recruiting | Pomeranian Medical University Szczecin | 20 | 2024-10-10 | 2024-12-24 | |
| The Efficacy of Lingual Aligners in Adults. Lingual aligners - Malocclusion, Angle Class I | Not applicable | Enrolling by invitation | University Hospital, Geneva | 20 | 2024-09-19 | 2024-10-18 |
| Assessment of Treatment Efficacy Using Smile Arc Marginal Ridge Approach Versus MBT Chart Method for Bracket Positioning Smile Arc Marginal Ridge Approach (SAMRA), MBT Chart Method - Class I Malocclusion | Not applicable | Recruiting | Cairo University | 30 | 2024-08-01 | 2024-10-22 |
| Bracket Positioning Techniques and Quality of Orthodontic Finishing Smile Arc Protection (SAP) bracket positioning, Smile Arc and Marginal Ridge Approach (SAMRA) bracket positioning; Procedure, McLaughlin-Bennett-Trevisi (MBT) chart bracket positioning - Malocclusion, Angle Class I, Dental Crowding | Not applicable | Completed | Future University in Egypt | 39 | 2024-07-01 | 2026-07-16 |
| AI-Assisted Versus Conventional Orthodontic Diagnosis and Treatment Planning Malocclusion, Angle Class I, Malocclusion, Angle Class II | Completed | Ben Hafeed Dental Center | 120 | 2024-03-03 | 2026-07-08 | |
| Direct vs Indirect In-House Clear Aligners vs Fixed Appliances in Orthodontic Treatment Direct In-House Clear Aligners, Indirect In-House Clear Aligners, Fixed Orthodontic Appliances - Malocclusion, Angle Class I | Not applicable | Completed | TC Erciyes University | 36 | 2024-02-15 | 2026-07-07 |
| Compartive Evalution of the Efficiency of Maxillary Canine Retraction Using Power Chain Versus Burstone T-loop BURSTONE T-LOOP - Class I Malocclusion | Not applicable | Unknown | Mansoura University | 12 | 2023-05-15 | 2023-05-31 |
| Root Resorption and Alveolar Bone in the Maxillary Canine Retraction Using Injectable Platelet-rich Fibrin: A Split-Mouth Trial Injectable platelet rich fbirin - Angle Class I | Not applicable | Completed | Can Tho University of Medicine and Pharmacy | 31 | 2022-08-27 | 2024-10-10 |
| Evaluating the Effect of Injectable Platelet Rich Fibrin on Tooth Movement Injectable platelet rich fbirin - Angle Class I | Not applicable | Completed | Can Tho University of Medicine and Pharmacy | 31 | 2022-08-15 | 2024-08-20 |
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Crowding (8) · Malocclusion, Angle Class II (7) · Malocclusion (5) · Malocclusion, Angle Class III (3) · Pain (2) · Alveolar Bone Loss (1) · Anodontia (1) · Gingivitis (1) · Root Resorption (1)
Stomatognathic Diseases (35) · Tooth Diseases (35) · Malocclusion (30) · Behavior (8) · Spatial Behavior (8) · Mouth Diseases (2) · Neurologic Manifestations (2) · Pathological Conditions, Signs and Symptoms (2) · Periodontal Diseases (2) · Signs and Symptoms (2) · Bone Diseases (1) · Bone Resorption (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Gingival Diseases (1)
Low-Level Light Therapy (2) · Orthodontic Appliances, Fixed (2) · Orthodontics (2) · Calcitriol (1) · Capsules (1) · Cerebral Decortication (1) · Mucograft (1) · Mutagenesis, Insertional (1) · Piezosurgery (1) · Population Groups (1) · Radionuclide Imaging (1)
Can Tho University of Medicine and Pharmacy (5) · Damascus University (3) · University of Baghdad (3) · Al-Azhar University (2) · Future University in Egypt (2) · State University of New York at Buffalo (2) · 3D-Aligners (1) · AL Yousef (1) · Ben Hafeed Dental Center (1) · Bezmialem Vakif University (1) · CES University (1) · Cairo University (1) · Fundación Universitaria CIEO (1) · Hesham Nabil Ali Al-Qamhawy (1) · Johns Hopkins University (1)
Egypt (7) · Vietnam (5) · Iraq (3) · Syria (3) · Turkey (Türkiye) (3) · United States (3) · Brazil (1) · India (1) · Pakistan (1) · Poland (1) · Saudi Arabia (1) · Switzerland (1) · Yemen (1)
Mohammad Y Hajeer, DDS MSc PhD (3) · Ahmed Ak El-Awady, Phd (1) · Claudia Forero (1) · Diem Chau Hong, DDS (1) · Farouk A Hussein, Professor (1) · Flavia Artese, PhD (1) · Hala Mounir, Prof (1) · Hallaj I Alsino, DDS (1) · Issam Khoury, DDS MSc PhD (1) · Jose Augusto M Miguel, PhD (1) · Lam Nguyen Le, Ph.D.DDS (1) · Mahmoud FA Aboelmahasen, Phd (1)
PMID 18929262, PMID 20018798, PMID 21640885, PMID 28339627, PMID 31161132, PMID 33459765, PMID 33653326, PMID 34141116, PMID 34181721, PMID 34625386, PMID 35265132, PMID 39230024, PMID 39893227, PMID 41073253, PMID 42852432