4 active not recruiting, 3 recruiting, 1 completed, 1 no longer available. 5 Phase 1, 3 Phase 2, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Recruiting 3, Active not recruiting 2 |
| Phase 2 | 3 | Active not recruiting 2, Terminated 1 |
| Not applicable | 1 | Completed 1 |
Follow Malignant Rhabdoid Tumor: new trials by email Literature Review of Malignant Rhabdoid Tumor trials Research Report on Malignant Rhabdoid Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Liver Cell Carcinoma | Phase 1 | Recruiting | Seattle Children's Hospital | 21 | 2025-12-22 | 2026-02-17 |
| Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells 21.15.GPC3-CAR T cells - Hepatoblastoma, Hepatocellular Carcinoma | Phase 1 | Recruiting | Baylor College of Medicine | 21 | 2025-06-10 | 2025-11-03 |
| Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors CARE T cells - Liver Cancer, Rhabdomyosarcoma | Phase 1 | Recruiting | Baylor College of Medicine | 24 | 2024-05-24 | 2026-08-06 |
| Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors AGAR T cells - Liver Cancer, Rhabdomyosarcoma | Phase 1 | Active not recruiting | Baylor College of Medicine | 14 | 2021-08-08 | 2026-01-21 |
| Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells for Solid Tumors CATCH T cells - Liver Cell Carcinoma, Solid Tumor | Phase 1 | Active not recruiting | Baylor College of Medicine | 12 | 2021-06-17 | 2026-03-06 |
| Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers Nivolumab, Ipilimumab - Malignant Rhabdoid Tumor, Rhabdoid Tumor of the Kidney | Phase 2 | Active not recruiting | Dana-Farber Cancer Institute | 30 | 2020-08-14 | 2026-10-20 |
| A Study of Panobinostat in Pediatric Patients With Solid Tumors Including MRT/ATRT Panobinostat - Rhabdoid Tumor, Atypical Teratoid/Rhabdoid Tumor | Phase 2 | Terminated | Australian & New Zealand Children's Haematology/Oncology Group | 25 | 2019-01-09 | 2025-02-24 |
| Molecular-Guided Therapy for Childhood Cancer Guided Therapy - Neuroblastoma, Medulloblastoma | Not applicable | Completed | Giselle Sholler | 186 | 2014-07-08 | 2025-11-03 |
| Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors alisertib, methotrexate, cisplatin - Malignant Rhabdoid Tumor, Atypical Teratoid Rhabdoid Tumor | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 125 | 2014-05-14 | 2026-09-01 |
| Tazemetostat Expanded Access Program for Adults With Solid Tumors Tazemetostat - Epithelioid Sarcoma (Ex-US Only), Spindle Cell Sarcoma | No longer available | Epizyme, Inc. | 2026-07-02 |
Rhabdoid Tumor (10) · Rhabdomyosarcoma (6) · Wilms Tumor (6) · Endodermal Sinus Tumor (5) · Liposarcoma (5) · Carcinoma, Hepatocellular (4) · Liver Neoplasms (4) · Carcinoma, Renal Cell (2) · Hepatoblastoma (2) · Sarcoma (2) · Brain Neoplasms (1) · Chondrosarcoma (1) · Chordoma (1) · Choroid Plexus Neoplasms (1) · Craniopharyngioma (1)
Neoplasms (10) · Neoplasms by Histologic Type (10) · Neoplasms, Complex and Mixed (10) · Neoplasms by Site (8) · Neoplasms, Connective and Soft Tissue (8) · Female Urogenital Diseases (7) · Female Urogenital Diseases and Pregnancy Complications (7) · Kidney Diseases (7) · Kidney Neoplasms (7) · Male Urogenital Diseases (7) · Urogenital Diseases (7) · Urogenital Neoplasms (7) · Urologic Diseases (7) · Urologic Neoplasms (7) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6)
Carboplatin (1) · Cisplatin (1) · Craniospinal Irradiation (1) · Cyclophosphamide (1) · Etoposide (1) · Ipilimumab (1) · MLN 8237 (1) · Methotrexate (1) · Nivolumab (1) · Panobinostat (1) · Radiotherapy (1) · Radiotherapy, Image-Guided (1) · Topotecan (1) · Vincristine (1) · etoposide phosphate (1)
Baylor College of Medicine (4) · Australian & New Zealand Children's Haematology/Oncology Group (1) · Dana-Farber Cancer Institute (1) · Epizyme, Inc. (1) · Giselle Sholler (1) · Seattle Children's Hospital (1) · St. Jude Children's Research Hospital (1)
United States (9) · Australia (1) · Lebanon (1) · New Zealand (1)
David Steffin, MD (3) · Amar Gajjar, MD (1) · Colleen Annesley, MD (1) · Corinne Summers, MD (1) · Giselle Sholler, MD (1) · Premal Lulla, MD (1) · Suzanne Forrest, MD (1) · Tannaz Armaghany, MD (1)