18 completed, 12 recruiting, 9 active not recruiting, 5 terminated. 21 Not applicable, 19 Phase 2, 9 Phase 1, 4 Phase 3.
Follow Radiotherapy, Image-Guided: new trials by email Literature Review of Radiotherapy, Image-Guided trials Research Report on Radiotherapy, Image-Guided
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Twenty-five Years of Advanced RadioTherapy at San Raffaele Hospital Advanced radiotherapy techniques - Malignant Tumor, Benign Neoplasm | Not yet recruiting | IRCCS San Raffaele | 10000 | 2026-11-15 | 2026-10-26 | |
| Molecular Imaging Informed Radiation Dose Escalation to Sites of Recurrent Disease and De-escalation to Uninvolved Areas in Salvage Radiotherapy Using SBRT for Prostate Cancer to Reduce Treatment Toxicity Image-guided Radiotherapy - Prostate Cancer (Adenocarcinoma) | Phase 2 | Not yet recruiting | University Health Network, Toronto | 50 | 2026-10-01 | 2026-09-28 |
| Phase II Study of Daily Adaptive Radiotherapy for Submandibular Gland-sparing in Head and Neck Cancer Daily adaptive radiation therapy, Image guided radiation therapy - Squamous Cell Cancer of Head and Neck (SCCHN) | Not applicable | Recruiting | University Health Network, Toronto | 50 | 2025-10-15 | 2026-03-04 |
| Pelvis Adaptive Radiotherapy (ART) Adaptive radiotherapy +/- margin reduction, Image guided radiotherapy - Pelvis Neoplasms | Not applicable | Recruiting | Royal North Shore Hospital | 280 | 2025-10-09 | 2026-02-05 |
| Prostate Adaptive Radiation Therapy Adaptive radiotherapy +/- Margin Reduction, Image guided radiotherapy - Prostatic Neoplasms | Not applicable | Recruiting | Royal North Shore Hospital | 130 | 2025-10-01 | 2026-02-05 |
| Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer Best Practice, Biospecimen Collection, Cisplatin - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Recruiting | NRG Oncology | 98 | 2025-06-23 | 2026-08-17 |
| Testing the Addition of an Immunotherapy Drug, Cemiplimab (REGN2810), Plus Surgery to the Usual Surgery Alone for Treating Advanced Skin Cancer Biospecimen Collection, Cemiplimab, Computed Tomography - Eyelid Squamous Cell Carcinoma, Recurrent Eyelid Squamous Cell Carcinoma | Phase 3 | Suspended | National Cancer Institute (NCI) | 420 | 2025-02-18 | 2026-10-20 |
| Relugolix and Enzalutamide in Combination With Radiation Therapy for the Treatment of Very High Risk Prostate Cancer, OPTIMAL Trial Biopsy, Biospecimen Collection, Computed Tomography - Prostate Adenocarcinoma | Phase 2 | Recruiting | Sean Sachdev | 50 | 2024-09-06 | 2026-06-05 |
| Biology-Guided Radiation Therapy for the Treatment of Patients With Bone Metastases Computed Tomography, Image Guided Radiation Therapy, Positron Emission Tomography - Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Solid Neoplasm | Phase 1 | Suspended | City of Hope Medical Center | 24 | 2024-08-25 | 2026-10-20 |
| Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial Abiraterone, Apalutamide, Biospecimen Collection - Recurrent Castration-Sensitive Prostate Carcinoma, Recurrent Prostate Cancer | Phase 2 | Recruiting | Mayo Clinic | 532 | 2024-06-03 | 2026-07-20 |
| Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer Biospecimen Collection, Carboplatin, Chest Radiography - Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma | Phase 2 | Withdrawn | ECOG-ACRIN Cancer Research Group | 2024-04-12 | 2024-07-25 | |
| Advanced Radiotherapy (ART) in Gynecological Cancer Patients (GYN-ART) Image Guided Radiotherapy - Gynecologic Cancer, Radiotherapy Side Effect | Recruiting | IRCCS San Raffaele | 1000 | 2024-02-15 | 2026-10-22 | |
| Adaptive Radiotherapy in Head and Neck Tumor Patients Adaptive Radiotherapy, image guided radiotherapy without online adaptation - Head and Neck Neoplasms, Head and Neck Cancer | Not applicable | Completed | University Hospital, Essen | 30 | 2024-01-25 | 2026-10-20 |
| Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer Carboplatin, Cisplatin, Computed Tomography - Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 474 | 2023-07-12 | 2026-08-17 |
| Molecular Imaging Informed Radiation Dose Escalation to Sites of Recurrent Disease and De-escalation to Uninvolved Areas in Salvage Radiotherapy for Prostate Cancer Image-guided Radiotherapy - Prostate Cancer | Not applicable | Recruiting | University Health Network, Toronto | 80 | 2022-08-23 | 2026-03-24 |
| Image-guided Focal Dose Escalation- Primary pc Treated With Primary External Beam Hypofract.Stereotactic rt Radiotherapy (RT) Arm A - IMRT/IGRT/SBRT, Radiotherapy (RT) Arm B - IMRT/IGRT - Prostate Cancer | Not applicable | Recruiting | University Hospital Freiburg | 374 | 2022-08-18 | 2024-03-26 |
| Advanced Radiotherapy (ART) in Prostate Cancer (PROST-ART) Image Guided Radiotherapy, Intensity Modulated Radiotherapy, Stereotactic Body Radiotherapy - Prostate Cancer | Recruiting | IRCCS San Raffaele | 2500 | 2022-02-14 | 2025-06-11 | |
| Metastasis Directed Stereotactic Body Radiotherapy for Oligo Metastatic Hormone Sensitive Prostate Cancer stereotactic body radiotherapy, androgen deprivation therapy, Radiotherapy - Prostate Cancer Metastatic, Radiation Therapy | Not applicable | Recruiting | Karin Soderkvist | 118 | 2021-10-27 | 2026-02-17 |
| A Study of TAK-676 With Pembrolizumab After Radiation Therapy to Treat a Number of Cancers Pembrolizumab, TAK-676, Image-guided radiation therapy - Carcinoma, Non-Small-Cell Lung, Triple Negative Breast Neoplasms | Phase 1 | Completed | Takeda | 34 | 2021-09-09 | 2025-09-04 |
| Phase II Concurrent Durvalumab and Radiotherapy for for Stage III Non-Small Cell Lung Cancer Thoracic RT and Durvalumab, Consolidative Durvalumab - Non Small Cell Lung Cancer, Lung Cancer Stage III | Phase 2 | Completed | University of Texas Southwestern Medical Center | 10 | 2020-04-03 | 2025-03-21 |
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Prostatic Neoplasms (16) · Carcinoma, Non-Small-Cell Lung (7) · Breast Neoplasms (5) · Squamous Cell Carcinoma of Head and Neck (5) · Head and Neck Neoplasms (4) · Lung Neoplasms (3) · Adenocarcinoma (2) · Carcinoma (2) · Carcinoma, Hepatocellular (2) · Carcinoma, Renal Cell (2) · Hypopharyngeal Neoplasms (2) · Laryngeal Neoplasms (2) · Mouth Neoplasms (2) · Neoplasm Metastasis (2) · Neoplasms (2)
IRCCS San Raffaele (3) · Mayo Clinic (3) · NRG Oncology (3) · National Cancer Institute (NCI) (3) · Stanford University (3) · University Health Network, Toronto (3) · ECOG-ACRIN Cancer Research Group (2) · Giselle Sholler (2) · Jonsson Comprehensive Cancer Center (2) · M.D. Anderson Cancer Center (2) · Royal North Shore Hospital (2) · University of Texas Southwestern Medical Center (2) · Abramson Cancer Center at Penn Medicine (1) · Beth Israel Medical Center (1) · Cancer Trials Ireland (1)
United States (32) · Canada (9) · Australia (3) · Italy (3) · Germany (2) · Netherlands (2) · Belgium (1) · China (1) · Finland (1) · France (1) · Ireland (1) · Israel (1) · Lebanon (1) · Portugal (1) · Spain (1)
Giselle Sholler, MD (2) · Aldrich Ong, MD (1) · Anca-Ligia Grosu, Prof. (1) · Andrei Fodor, MD (1) · Andrew Kneebone (1) · Andrew Loblaw, MD (1) · Andrew Prof Kneebone, MBBS (1) · Carmen Perez, M.D. (1) · Charles B Simone (1) · David M Brizel (1) · Deborah E. Citrin, MD (1) · Douglas R Adkins, M.D. (1) · Edwin Posadas, MD (1) · Gina Vaccaro (1)
PMID 11704310, PMID 12128137, PMID 15183474, PMID 17706308, PMID 18374511, PMID 19056184, PMID 19880262, PMID 20009882, PMID 21514629, PMID 22266935, PMID 22270280, PMID 22543211, PMID 23176540, PMID 23332384, PMID 24101042, PMID 24985964, PMID 25701298, PMID 26392096, PMID 26503201, PMID 26634381, PMID 26696788, PMID 26961088, PMID 27044935, PMID 27104782, PMID 27339115, PMID 27339116, PMID 27626136, PMID 27626365, PMID 28065538, PMID 28296582, PMID 28708043, PMID 29240541, PMID 29528761, PMID 29551231, PMID 30207593, PMID 30355464, PMID 30867104, PMID 31150869, PMID 31227373, PMID 31821973, PMID 31908301, PMID 31971828, PMID 31987969, PMID 32043791, PMID 32484754, PMID 32536001, PMID 32580883, PMID 32665297, PMID 33002429, PMID 33002431
U10CA180868 (4), P30CA015083 (2), U10CA180820 (2), P01CA021239 (1), P30CA016672 (1), P30CA033572 (1), P30CA060553 (1), P50CA070907 (1), R01CA286127 (1), R01CA300454 (1), R21CA153587 (1), U01CA062461 (1), U19CA021239 (1), UG1CA189867 (1), UM1CA186688 (1)