49 completed, 13 unknown, 6 terminated, 5 recruiting. 46 Phase 2, 29 Phase 1, 6 Not applicable, 3 Phase 3, 1 Early Phase 1.
Follow Malignant Pleural Mesothelioma: new trials by email Literature Review of Malignant Pleural Mesothelioma trials Research Report on Malignant Pleural Mesothelioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comprehensive Oncogenomic Mapping and Exploration in Thoracic and Head & Neck Oncology Blood and Tissue Collection - Small Cell Lung Cancer, Head and Neck Cancer | Not yet recruiting | University of Kansas Medical Center | 110 | 2026-04-01 | 2026-04-24 | |
| OT-101 in Combination With Pembrolizumab in Subjects With Malignant Pleural Mesothelioma Failing to Respond to Checkpoint Inhibition OT-101 - Malignant Pleural Mesothelioma | Phase 2 | Not yet recruiting | Oncotelic Inc. | 63 | 2025-06-01 | 2024-03-15 |
| Hemithoracic Arc Radiotherapy Post Pleural Decortication hemithoracic Volumetric Arc Radiotherapy post Pleural decortication - Malignant Pleural Mesothelioma | Not applicable | Completed | Cairo University | 45 | 2024-11-11 | 2026-10-30 |
| Hemithoracic Irradiation With Proton Therapy in Malignant Pleural Mesothelioma Proton beam therapy - Malignant Pleural Mesothelioma | Not applicable | Recruiting | University College, London | 148 | 2024-03-28 | 2026-03-30 |
| Study of Pembrolizumab Plus Chemotherapy With Lenvatinib for Malignant Pleural Mesothelioma Lenvatinib, Pemetrexed, Cisplatin/Carboplatin - Malignant Pleural Mesothelioma | Phase 2 | Active not recruiting | Hyogo Medical University | 25 | 2024-03-13 | 2026-09-16 |
| Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma E-Nose testing, Research blood - Malignant Pleural Mesothelioma | Not applicable | Recruiting | Memorial Sloan Kettering Cancer Center | 20 | 2023-09-08 | 2026-09-24 |
| Regorafenib With Tislelizumab in Patients With Selected Mismatch Repair-Proficient/Microsatellite Stable Cancers Regorafenib in combination with Tislelizumab - Anal Squamous Cell Carcinoma, Colorectal Neoplasms | Phase 2 | Withdrawn | Translational Research in Oncology | 2023-04-30 | 2023-06-07 | |
| Switch-Maintenance Gemcitabine After First-Line Chemotherapy In Patients With Malignant Pleural Mesothelioma Gemcitabine, supportive care - Malignant Pleural Mesothelioma | Phase 2 | Completed | Ain Shams University | 40 | 2023-04-01 | 2024-08-27 |
| A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors CTX131 - Clear Cell Renal Cell Carcinoma, Cervical Carcinoma | Phase 1 / Phase 2 | Completed | CRISPR Therapeutics AG | 19 | 2023-03-13 | 2025-11-26 |
| Integration of the PD-L1 Inhibitor Atezolizumab and WT1/DC Vaccination Into Platinum/Pemetrexed-based First-line Treatment for Epithelioid Malignant Pleural Mesothelioma Dendritic cell vaccination, Atezolizumab, Platinum/pemetrexed based chemotherapy - Malignant Pleural Mesothelioma | Phase 1 / Phase 2 | Recruiting | University Hospital, Antwerp | 15 | 2023-02-24 | 2026-06-05 |
| AMT-151 in Patients With Selected Advanced Solid Tumours AMT-151 - Advanced Solid Tumor, Advanced Cancer | Phase 1 | Unknown | Multitude Therapeutics Inc. | 30 | 2023-01-25 | 2023-10-19 |
| The IMmunotherapy Pleural 5-ALA PDT intrapleural photodynamic therapy with videothoracoscopy, Nivolumab Injection - Mesotheliomas Pleural, Malignant Pleural Mesothelioma | Phase 2 | Recruiting | University Hospital, Lille | 20 | 2022-05-09 | 2025-09-25 |
| Observational Study in Patients With Previously Unresectable Malignant Pleural Mesothelioma Treated With Nivolumab and Ipilimumab (MESO-IMMUNE) Data collection - Malignant Pleural Mesothelioma, Unresectable Malignant Neoplasm | Completed | Groupe Francais De Pneumo-Cancerologie | 204 | 2022-05-03 | 2025-10-06 | |
| Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma RSO-021 - Malignant Pleural Effusion, Malignant Pleural Mesothelioma | Phase 1 / Phase 2 | Completed | RS Oncology LLC | 50 | 2022-03-31 | 2026-07-24 |
| Effect of HITHOC After Pleurectomy Decortication for Treatment of Malignant Pleural Mesothelioma hyperthermic intrathoracic chemotherapy - Malignant Pleural Mesothelioma, Chemotherapy Effect | Not applicable | Unknown | Ain Shams University | 50 | 2022-03-01 | 2022-08-22 |
| A Study of Pembrolizumab and Radiation Therapy in People With Mesothelioma Pembrolizumab, IMPRINT - Malignant Pleural Mesothelioma | Phase 1 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 7 | 2021-08-10 | 2026-03-12 |
| Real World Study of MPM in China Malignant Pleural Mesothelioma, Diagnoses Disease | Unknown | Chinese Academy of Medical Sciences | 500 | 2021-06-01 | 2021-09-13 | |
| SAKK 17/18 (ORIGIN) MPM & NSCLC >1st Line Gemci & Atezo Ph II Gemcitabine, Atezolizumab - Malignant Pleural Mesothelioma, Non-small Cell Lung Cancer | Phase 2 | Completed | Swiss Cancer Institute | 68 | 2021-03-17 | 2024-07-01 |
| DuRvalumab With chEmotherapy as First Line treAtment in Advanced Pleural Mesothelioma Durvalumab, Standard Chemotherapy, Ipilimumab and Nivolumab - Mesothelioma, Pleural Mesothelioma | Phase 3 | Completed | PrECOG, LLC. | 214 | 2021-02-18 | 2026-10-22 |
| Neoadjuvant Toripalimab Combined With Chemotherapy in the Treatment of Malignant Pleural Mesothelioma Toripalimab - Malignant Pleural Mesothelioma | Phase 2 | Unknown | Shanghai Pulmonary Hospital, Shanghai, China | 15 | 2021-02-01 | 2021-01-26 |
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Mesothelioma, Malignant (83) · Mesothelioma (15) · Carcinoma, Non-Small-Cell Lung (6) · Esophageal Neoplasms (3) · Neoplasms (3) · Carcinoma (2) · Ovarian Neoplasms (2) · Sarcoma (2) · Small Cell Lung Carcinoma (2) · Wilms Tumor (2) · Adenocarcinoma of Lung (1) · Adenoma (1) · Anus Neoplasms (1) · Carcinoma, Ovarian Epithelial (1) · Carcinoma, Renal Cell (1)
Lung Diseases (83) · Neoplasms by Histologic Type (83) · Neoplasms by Site (83) · Neoplasms, Glandular and Epithelial (83) · Pleural Neoplasms (83) · Respiratory Tract Diseases (83) · Respiratory Tract Neoplasms (83) · Thoracic Neoplasms (83) · Adenoma (82) · Lung Neoplasms (82) · Neoplasms, Mesothelial (82) · Neoplasms (80) · Mesothelioma (68) · Bronchial Neoplasms (8) · Carcinoma, Bronchogenic (8)
Cisplatin (20) · Pemetrexed (18) · Carboplatin (6) · Nivolumab (6) · Gemcitabine (5) · pembrolizumab (5) · Drug Therapy (4) · sodium thiosulfate (4) · Cerebral Decortication (3) · defactinib (3) · Cyclophosphamide (2) · Data Collection (2) · Ipilimumab (2) · atezolizumab (2) · tumor necrosis factor-alpha, CNGRC fusion protein, human (2)
Ain Shams University (5) · Memorial Sloan Kettering Cancer Center (5) · Dana-Farber Cancer Institute (3) · The Netherlands Cancer Institute (3) · AGC Biologics S.p.A. (2) · Aduro Biotech, Inc. (2) · Armando Santoro, MD (2) · Copenhagen University Hospital, Rigshospitalet (2) · European Organisation for Research and Treatment of Cancer - EORTC (2) · Istituto Clinico Humanitas (2) · University College, London (2) · University Hospital, Antwerp (2) · University Hospital, Lille (2) · University of Zurich (2) · Verastem, Inc. (2)
United States (29) · Italy (12) · United Kingdom (9) · France (8) · Netherlands (8) · Belgium (7) · Canada (6) · Egypt (6) · Australia (5) · Japan (5) · Germany (4) · Poland (4) · Spain (4) · China (3) · Switzerland (3)
Armando Santoro, MD (3) · David J. Sugarbaker, MD (3) · Antonio Lambiase, MD (2) · Omar Abdel-Rahman, MD (2) · Paul Baas, MD, PhD (2) · Raphael Bueno, MD (2) · Zwi N Berneman, MD, PhD (2) · Abanoub Samir (1) · Adnan Khosravi, Assoc. Prof. (1) · Alessandra Curioni Fontecedro, MD (1) · Alessandra Curioni, MD (1) · Andrew Haas, MD, PhD (1) · Anna Nowak, MD (1) · Anne S. Tsao, MD (1) · Arnaud Scherpereel, MD, PhD (1)
PMID 37279993, PMID 10500494, PMID 11165136, PMID 11487589, PMID 16554548, PMID 17295916, PMID 17395581, PMID 18797818, PMID 19360120, PMID 19556318, PMID 19564349, PMID 19652065, PMID 20167848, PMID 20406925, PMID 20549206, PMID 20615924, PMID 20647340, PMID 21135147, PMID 21149657, PMID 21262916, PMID 21467219, PMID 21632857, PMID 21642245, PMID 22065672, PMID 22353806, PMID 23032745, PMID 23248097, PMID 23785047, PMID 24148817, PMID 2418164, PMID 24366885, PMID 24445595, PMID 24484236, PMID 24487185, PMID 24739759, PMID 24777247, PMID 24777970, PMID 24852691, PMID 25281915, PMID 26968202, PMID 27449804, PMID 27584578, PMID 27594672, PMID 28298401, PMID 28870611, PMID 28972039, PMID 29753703, PMID 29975406, PMID 30660511, PMID 30687504
2009 (2), 2008 (1), 2015 (1), 2017 (1), 2019 (1), P01CA066726 (1)