38 completed, 22 unknown, 15 recruiting, 5 active not recruiting. 23 Not applicable, 18 Phase 2, 17 Phase 1, 9 Phase 3, 4 Phase 4.
Follow Malignancy: new trials by email Literature Review of Malignancy trials Research Report on Malignancy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Study Evaluating Tumor Microenvironment Interaction in Solid Tumor Patients 68Ga-FAPI-46 - Solid Tumor Cancer, Solid Tumor Malignancy | Early Phase 1 | Withdrawn | Eben Rosenthal | 2027-01-01 | 2026-01-21 | |
| Off-Label Treatment With Immune Checkpoint Inhibitor Blockade One or more off-label ICIs alone or with other on-label ICI(s), Off-label ICI(s) with targeted therapy, off-label ICI(s) with other agents that are not targeted (including, but not limited to, chemotherapy, hormonal therapy, immunotherapy other than ICIs) with or without targeted agents - Malignancy | Phase 2 | Not yet recruiting | Medical College of Wisconsin | 231 | 2026-11-01 | 2026-08-10 |
| Maternal and Fetal Outcomes in Pregnancy With Malignancy Pregnancy Disease, Malignancy | Not yet recruiting | Assiut University | 50 | 2026-10-20 | 2026-10-20 | |
| Sedation Methods in Percutaneous Transhepatic Biliary Drainage: Procedure Quality and Recovery Remifentanil, Ketamine - Fragility, Biliary Obstruction | Not applicable | Recruiting | Ankara City Hospital Bilkent | 98 | 2026-02-01 | 2026-06-10 |
| DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers. Entrectinib - Haematological Malignancy, Malignancy | Phase 2 / Phase 3 | Recruiting | Cancer Research UK | 30 | 2025-11-30 | 2025-11-24 |
| Assessment of the Impact of Increased Production of Reactive Oxygen Species Produced During Repeated Sessions of Hyperbaric Oxygen Therapy in Patients Undergoing Radiotherapy for Neoplasia, on the Occurrence of DNA Damage Blood test - Hyperbaric Oxygen, Genotoxicity | Not applicable | Recruiting | University Hospital, Angers | 60 | 2025-07-08 | 2026-04-06 |
| Evaluating Informatics-assisted Immune-related Adverse Event Detection to Improve Registration Onto a Biorepository Informatics system for eligibility monitoring, Standard eligibility monitoring - Malignancy, Immune Related Adverse Events | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 100 | 2025-06-17 | 2025-06-19 |
| Immune Reconstitution Monitoring and Pneumococcal Vaccination in Patients Treated With CAR-T Cells Commercial CAR-T, Investigational CAR-T - Malignancy, Cancer | Phase 1 / Phase 2 | Withdrawn | UNC Lineberger Comprehensive Cancer Center | 2025-01-20 | 2026-01-06 | |
| Target-specific immunoPET Imaging of Digestive System Carcinoma [68Ga]Ga-DOTA-H2D3, [18F]F-RESCA-RB14, [68Ga]Ga-NOTA-T4 - Malignancy, Digestive Cancer | Not applicable | Recruiting | RenJi Hospital | 400 | 2024-12-04 | 2025-12-31 |
| Allogeneic NKG2DL-targeting CAR γδ T Cells (CTM-N2D) in Advanced Cancers (ANGELICA) Allogeneic NKG2DL-targeting Chimeric Antigen Receptor-grafted γδ T Cells (CTM-N2D) - Cancer, Malignancy | Phase 1 | Recruiting | CytoMed Therapeutics Pte Ltd | 12 | 2024-11-19 | 2024-11-22 |
| DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations Capmatinib - Solid Tumour, Haematological Malignancy | Phase 2 / Phase 3 | Recruiting | Cancer Research UK | 30 | 2024-11-19 | 2025-11-24 |
| Feasibility of Ambulatory Talc. Pleurodesis ambulatory chest drain and talc pleurodesis - Malignant Pleural Effusion, Malignancy | Not applicable | Recruiting | David Rollins | 15 | 2024-01-10 | 2024-11-12 |
| Tandem Polyurethane Stents Compared to Single Silicone Stent for Malignant Ureteral Obstruction ureteral stent\s insertion - Hydronephrosis; Obstruction, Ureter, Renal Failure | Not applicable | Recruiting | Rabin Medical Center | 106 | 2023-12-20 | 2025-07-24 |
| Community Health Worker Based Intervention to Improve Palliative Care Community Health Worker (CHW) based palliative care - Cancer, End Stage Cancer | Not applicable | Enrolling by invitation | Wake Forest University Health Sciences | 160 | 2023-11-02 | 2026-07-23 |
| DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition Atezolizumab - Malignancy, Malignant Neoplasm | Phase 2 / Phase 3 | Recruiting | Cancer Research UK | 30 | 2023-10-25 | 2025-11-24 |
| Novel Outreach Methods to Increase Enrollment to Early Phase Clinical Trials Digital Intervention, Community Outreach - Cancer, Malignancy | Not applicable | Active not recruiting | University of Chicago | 134 | 2023-10-23 | 2026-04-27 |
| Obstruction of Malignancy: Percutaneous Renal vs Endoscopic Stent Ureteral Stent, Percutaneous Nephrostomy Tube Placement - Cancer, Urinary Obstruction | Early Phase 1 | Withdrawn | University of Chicago | 2023-09-22 | 2024-12-19 | |
| Evaluation of the Effectiveness of Prophylactic LMWH by Thromboelastography Malignancy | Completed | Ege University | 25 | 2023-07-24 | 2025-08-12 | |
| Feasibility Study of Intra-Tumoral Lipopolysaccharide Immunotherapy for Intra-Abdominal Tumors Lipopolysaccharide - Abdominal Cancer, Malignancy | Phase 1 | Completed | Patrick Wagner, MD, FACS | 12 | 2023-03-16 | 2026-06-15 |
| Application of Al18F-NOTA-FAPI PET/CT in Malignant Tumors Expressing Fibroblast-activated Proteins Al18F-NOTA-FAPI - Malignancy | Phase 2 / Phase 3 | Unknown | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 500 | 2023-01-08 | 2024-03-29 |
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Neoplasms (92) · Hematologic Neoplasms (5) · Melanoma (4) · Neoplasm Metastasis (4) · Pancreatic Neoplasms (4) · Agnosia (3) · Carcinoma (3) · Cardiovascular Diseases (3) · Colorectal Neoplasms (3) · Diabetes Mellitus (3) · Glioma (3) · Heart Failure (3) · Infections (3) · Lung Neoplasms (3) · Lymphoproliferative Disorders (3)
Pathological Conditions, Signs and Symptoms (23) · Neoplasms by Site (17) · Digestive System Diseases (15) · Pathologic Processes (15) · Respiratory Tract Diseases (13) · Neoplasms by Histologic Type (12) · Urogenital Diseases (12) · Cardiovascular Diseases (11) · Hemic and Lymphatic Diseases (11) · Lung Diseases (10) · Signs and Symptoms (10) · Female Urogenital Diseases (9) · Female Urogenital Diseases and Pregnancy Complications (9) · Lymphatic Diseases (9) · Male Urogenital Diseases (9)
Antilymphocyte Serum (2) · Bendamustine Hydrochloride (2) · Granulocyte Colony-Stimulating Factor (2) · Radiotherapy (2) · Rituximab (2) · Thermography (2) · Abatacept (1) · Acetaminophen (1) · Bortezomib (1) · Capecitabine (1) · Community Health Workers (1) · Community-Institutional Relations (1) · Cyclophosphamide (1) · Cyclosporine (1) · Diet, Fat-Restricted (1)
Assiut University (3) · Cancer Research UK (3) · Brigham and Women's Hospital (2) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (2) · Pfizer (2) · Rabin Medical Center (2) · Royal Marsden NHS Foundation Trust (2) · Sheba Medical Center (2) · UNC Lineberger Comprehensive Cancer Center (2) · University of Chicago (2) · Wake Forest University Health Sciences (2) · AI Labs Group S.L (1) · Abramson Cancer Center at Penn Medicine (1) · Akeso (1) · Alaunos Therapeutics (1)
United States (31) · United Kingdom (9) · China (8) · Canada (6) · Israel (3) · Netherlands (3) · South Korea (3) · Spain (3) · Germany (2) · Hong Kong (2) · Turkey (Türkiye) (2) · Australia (1) · Egypt (1) · France (1) · India (1)
Matthew Krebs, Dr (3) · Albert Moore, MD (1) · Alex HL Wong, MMedSc (1) · Ampika Mangklabruks, MD (1) · Anand D Jeyasekharan, Dr (1) · Atiporn Ingsathit, MD, PhD (1) · Brent E Burbridge, MD, FRCPC (1) · Briseis Aschebrook-Kilfoy (1) · Chaicharn Deerochanawong, MD (1) · Chanida Pachotikarn, PhD (1)
PMID 10737280, PMID 10963635, PMID 12393647, PMID 20937120, PMID 21487108, PMID 22551422, PMID 22898071, PMID 23702623, PMID 23725876, PMID 24174627, PMID 25231836, PMID 25331113, PMID 25716544, PMID 26407753, PMID 26474775, PMID 26505825, PMID 26867832, PMID 27064675, PMID 27095446, PMID 27440084, PMID 27477483, PMID 27707805, PMID 28373761, PMID 28408140, PMID 29054923, PMID 29274507, PMID 29685478, PMID 30103252, PMID 30165472, PMID 30475968, PMID 30621982, PMID 30852029, PMID 30852540, PMID 30918939, PMID 31504429, PMID 31605877, PMID 31630479, PMID 32619621, PMID 32723508, PMID 32903262, PMID 33153401, PMID 33720337, PMID 33766036, PMID 33931973, PMID 34030728, PMID 34256732, PMID 34353985, PMID 34372670, PMID 34414517, PMID 34594036
2017 (1), R01CA252101 (1), R01CA294033 (1), R01MD016935 (1), U19AR069525 (1)