9 recruiting, 6 completed, 1 not yet recruiting, 1 terminated. 8 Phase 2, 4 Not applicable, 2 Phase 1, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Recruiting 6, Completed 1, Terminated 1 |
| Not applicable | 4 | Completed 2, Recruiting 2 |
| Phase 1 | 2 | Terminated 1, Withdrawn 1 |
| Phase 3 | 1 | Recruiting 1 |
| Phase 4 | 1 | Completed 1 |
Follow Lymphatic Malformation: new trials by email Literature Review of Lymphatic Malformation trials Research Report on Lymphatic Malformation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intralesional Bleomycin Sclerotherapy for Low-Flow Vascular Malformations of the Head and Neck Bleomycin (Bleocel 15) - Vascular Malformations, Venous Malformation | Phase 4 | Completed | University Of Anbar | 20 | 2025-08-25 | 2026-07-27 |
| Diagnostic Imaging of Vascular Malformations Using MSOT and ULM Multispectral Optoacoustic Tomography, Ultrasound Localization Microscopy - Vascular Malformation, Arteriovenous Malformation | Not yet recruiting | University Hospital Erlangen | 15 | 2025-08-01 | 2025-06-22 | |
| Different Doses of Sirolimus for the Treatment of Cystic Lymphatic Malformations Sirolimus (RAPAMUNE) - Lymphatic Malformation | Phase 2 / Phase 3 | Recruiting | West China Hospital | 150 | 2024-11-30 | 2024-12-31 |
| A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations Alpelisib, Mirdametinib - Slow-Flow Vascular Malformation, Fast-Flow Vascular Malformation | Phase 2 | Recruiting | Murdoch Childrens Research Institute | 50 | 2024-09-13 | 2026-05-05 |
| Institution of an Italian Registry and Biobank for Biological Sample Collection Genetic profiling of all eligible patients - Lymphatic Malformation, Lymphatic Abnormality | Not applicable | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 70 | 2024-06-27 | 2025-03-25 |
| Safety and Efficacy Study of Intracystic TARA-002 for the Treatment of Lymphatic Malformations in Participants 6 Months to Less Than 18 Years of Age TARA-002 - Lymphatic Malformation | Phase 2 | Recruiting | Protara Therapeutics | 38 | 2023-10-18 | 2026-08-24 |
| Use of Bleomycin in the Sclerotherapy of Lymphatic Malformations for Pediatric Patients Bleomycin - Lymphatic Malformation | Phase 2 | Recruiting | West China Hospital | 200 | 2023-03-08 | 2024-06-03 |
| National Evaluation of Patients With PIK3CA-Related Overgrowth Spectrum (PROS) national registry - PIK3CA-related Overgrowth Spectrum, CLOVES Syndrome | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 28 | 2023-02-21 | 2026-02-23 | |
| A Prospective Study on the Treatment of cLM Based on ICG Imaging Inflow occlusion with perforation of septation and sclerotherapy, Perforation of septation and sclerotherapy, Indocyanine green-guided partial resection and sclerotherapy - Lymphatic Malformation | Not applicable | Recruiting | Nanjing Children's Hospital | 110 | 2023-01-01 | 2026-02-18 |
| Weekly Sirolimus Therapy Sirolimus - Venous Malformation, Lymphatic Malformation | Phase 2 | Recruiting | Medical University of South Carolina | 24 | 2022-01-18 | 2026-03-05 |
| A Pharmacokinetic, Pharmacodynamic, Safety and Tolerability Study of CERC-006 in Adults With Complex Lymphatic Malformations CERC-006 - Lymphatic Malformation | Phase 1 | Withdrawn | Avalo Therapeutics, Inc. | 2021-09-03 | 2022-03-22 | |
| Vascular Anomaly Pathology and Genomics Biopsy Study Percutaneous Vascular Anomaly/Malformation Biopsy - Vascular Malformations, Vascular Anomaly | Not applicable | Completed | Mayo Clinic | 3 | 2021-04-06 | 2022-04-21 |
| First in Human Trial of Topical VT30 in Pts With Venous/Lymphatic Malformations Assoc With PIK3CA or TEK Gene Mutations VT30 - Venous Malformation, Lymphatic Malformation | Phase 1 / Phase 2 | Terminated | Venthera, Inc., a BridgeBio company | 15 | 2020-10-01 | 2022-08-04 |
| Topical Sirolimus in Cutaneous Lymphatic Malformations Topical 0.1% Sirolimus, Topical Vehicle - Vascular Malformations, Lymphatic Malformation | Phase 2 | Completed | University Hospital, Tours | 55 | 2019-06-05 | 2026-02-13 |
| Indocyanine Green Lymphography in Management of Lingual Lymphatic Malformation ICGL-guided treatment, Conventional Treatment group - Lymphatic Malformation | Not applicable | Completed | Nanjing Children's Hospital | 42 | 2019-01-01 | 2025-03-13 |
| Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations rapamycin, MRI, Rapamycin dosage - Lymphatic Malformation, Pediatric | Phase 2 | Recruiting | University Hospital, Lille | 28 | 2018-06-25 | 2026-05-22 |
| Lymphatic Anomalies Registry for the Assessment of Outcome Data Lymphatic Malformation, Generalized Lymphatic Anomaly (GLA) | Recruiting | Boston Children's Hospital | 1000 | 2013-06-01 | 2026-09-10 | |
| Clinical Characteristics of Lymphatic Malformations Compare the epidemiological characteristics, clinical presentations, surgical treatments and risk factors for preoperative complications of ALMs between paediatric and adult participants. - Lymphatic Malformation, Lymphangioma | Completed | West China Hospital | 320 | 2009-01-01 | 2024-02-14 |
Lymphatic Abnormalities (18) · Vascular Malformations (7) · Arteriovenous Malformations (3) · Klippel-Trenaunay-Weber Syndrome (3) · Lymphangioma (3) · Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi (2) · Abdomen, Acute (1) · Blue rubber bleb nevus syndrome (1) · Hemangioma (1) · Hereditary Sensory and Autonomic Neuropathies (1) · Kaposiform Hemangioendothelioma (1) · Lymphangioma, Cystic (1) · Megalencephaly (1) · Megalodactyly (1) · Osteolysis, Essential (1)
Congenital Abnormalities (18) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (18) · Hemic and Lymphatic Diseases (18) · Lymphatic Diseases (18) · Cardiovascular Abnormalities (7) · Cardiovascular Diseases (7) · Vascular Diseases (5) · Neoplasms (4) · Neoplasms by Histologic Type (4) · Angiomatosis (3) · Neoplasm, Lymphatic Tissue (3) · Musculoskeletal Diseases (2) · Abdominal Pain (1) · Bone Diseases (1) · Bone Diseases, Developmental (1)
Sirolimus (4) · Bleomycin (2) · Alpelisib (1) · Risk Factors (1) · Sclerotherapy (1) · Surgical Procedures, Operative (1) · Zeocin (1) · calcium D-pantothenate, L-cysteine drug combination (1) · mirdametinib (1)
West China Hospital (3) · Nanjing Children's Hospital (2) · Avalo Therapeutics, Inc. (1) · Boston Children's Hospital (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Mayo Clinic (1) · Medical University of South Carolina (1) · Murdoch Childrens Research Institute (1) · Protara Therapeutics (1) · University Hospital Erlangen (1) · University Hospital, Lille (1) · University Hospital, Tours (1) · University Of Anbar (1) · Venthera, Inc., a BridgeBio company (1)
United States (6) · China (5) · France (3) · Australia (1) · Germany (1) · Iraq (1) · Italy (1)
Chelsea Shope, MSCR (1) · Chiara Leoni (1) · David A Woodrum, MD, PhD (1) · Emily Bendel, MD (1) · Guillaume Canaud, MD,PHD (1) · Lydia Pathmanathan, MBBS, FRACP. (1) · Marilyn Liang, M.D. (1) · Michael Henderson (1) · Pierre Fayoux, MD (1) · Stephen Luen, MBChB, FRACP. (1) · Tony Penington, MBBS, FRACS. (1) · Weimin Shen, Dr. (1) · Yi Ji, Ph.D. (1)
PMID 28782106, PMID 24252784, PMID 28431241, PMID 29899452, PMID 30240774, PMID 30980684, PMID 31236308, PMID 31734224, PMID 31847908, PMID 34524406, PMID 36044195, PMID 36271467, PMID 37423005, PMID 37717734, PMID 38390569, PMID 39044220, PMID 40660315
2018 (1)