6 recruiting, 1 completed, 1 terminated. 8 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Recruiting 6, Completed 1, Terminated 1 |
| Phase 1 | 1 | Terminated 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Lymphatic Malformation: new trials by email Literature Review of Lymphatic Malformation trials Research Report on Lymphatic Malformation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Different Doses of Sirolimus for the Treatment of Cystic Lymphatic Malformations Sirolimus (RAPAMUNE) - Lymphatic Malformation | Phase 2 / Phase 3 | Recruiting | West China Hospital | 150 | 2024-11-30 | 2024-12-31 |
| A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations Alpelisib, Mirdametinib - Slow-Flow Vascular Malformation, Fast-Flow Vascular Malformation | Phase 2 | Recruiting | Murdoch Childrens Research Institute | 50 | 2024-09-13 | 2026-05-05 |
| Safety and Efficacy Study of Intracystic TARA-002 for the Treatment of Lymphatic Malformations in Participants 6 Months to Less Than 18 Years of Age TARA-002 - Lymphatic Malformation | Phase 2 | Recruiting | Protara Therapeutics | 38 | 2023-10-18 | 2026-08-24 |
| Use of Bleomycin in the Sclerotherapy of Lymphatic Malformations for Pediatric Patients Bleomycin - Lymphatic Malformation | Phase 2 | Recruiting | West China Hospital | 200 | 2023-03-08 | 2024-06-03 |
| Weekly Sirolimus Therapy Sirolimus - Venous Malformation, Lymphatic Malformation | Phase 2 | Recruiting | Medical University of South Carolina | 24 | 2022-01-18 | 2026-03-05 |
| First in Human Trial of Topical VT30 in Pts With Venous/Lymphatic Malformations Assoc With PIK3CA or TEK Gene Mutations VT30 - Venous Malformation, Lymphatic Malformation | Phase 1 / Phase 2 | Terminated | Venthera, Inc., a BridgeBio company | 15 | 2020-10-01 | 2022-08-04 |
| Topical Sirolimus in Cutaneous Lymphatic Malformations Topical 0.1% Sirolimus, Topical Vehicle - Vascular Malformations, Lymphatic Malformation | Phase 2 | Completed | University Hospital, Tours | 55 | 2019-06-05 | 2026-02-13 |
| Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations rapamycin, MRI, Rapamycin dosage - Lymphatic Malformation, Pediatric | Phase 2 | Recruiting | University Hospital, Lille | 28 | 2018-06-25 | 2026-05-22 |
Lymphatic Abnormalities (8) · Vascular Malformations (2) · Arteriovenous Malformations (1) · Lymphangioma (1) · Lymphangioma, Cystic (1) · Skin Diseases, Vascular (1)
Congenital Abnormalities (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Hemic and Lymphatic Diseases (8) · Lymphatic Diseases (8) · Cardiovascular Abnormalities (2) · Cardiovascular Diseases (2) · Neoplasm, Lymphatic Tissue (1) · Neoplasms (1) · Neoplasms by Histologic Type (1) · Skin Diseases (1) · Skin and Connective Tissue Diseases (1) · Vascular Diseases (1)
Sirolimus (4) · Alpelisib (1) · Bleomycin (1) · Zeocin (1) · calcium D-pantothenate, L-cysteine drug combination (1) · mirdametinib (1)
West China Hospital (2) · Medical University of South Carolina (1) · Murdoch Childrens Research Institute (1) · Protara Therapeutics (1) · University Hospital, Lille (1) · University Hospital, Tours (1) · Venthera, Inc., a BridgeBio company (1)
United States (3) · China (2) · France (2) · Australia (1)
Chelsea Shope, MSCR (1) · Lydia Pathmanathan, MBBS, FRACP. (1) · Michael Henderson (1) · Pierre Fayoux, MD (1) · Stephen Luen, MBChB, FRACP. (1) · Tony Penington, MBBS, FRACS. (1)
PMID 28782106, PMID 30240774, PMID 30980684, PMID 31236308, PMID 31734224, PMID 31847908, PMID 34524406, PMID 36044195, PMID 36271467, PMID 37423005, PMID 37717734, PMID 38390569
2018 (1)