26 completed, 4 unknown, 3 withdrawn, 2 recruiting. 37 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 37 | Completed 26, Unknown 4, Withdrawn 3, Recruiting 2, Terminated 2 |
| Phase 2 | 4 | Unknown 3, Completed 1 |
Follow Liver Transplantation: new trials by email Literature Review of Liver Transplantation trials Research Report on Liver Transplantation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Everolimus bAsed caLcineurin inhibiTor frEe immunosuppRession oNe Year AfTer lIver transplantatiON (ALTERNATION) Everolimus, Tacrolimus or Cyclosporine - Liver Allograft, Liver Diseases | Phase 3 | Recruiting | Hannover Medical School | 150 | 2026-08-19 | 2026-10-05 |
| Neo-adjuvant Transarterial Chemoinfusion (TAI) for Patients With Hepatocellular Carcinoma Beyond Milan/UCSF Criteria Who Underwent Liver Transplantation Transarterial chemoinfusion (TAI) with mFOLFOX6 (oxaliplatin, calcium folinate, and 5-FU) - Hepatocellular Carcinoma, Liver Transplantation | Phase 3 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 40 | 2020-11-01 | 2021-11-05 |
| Lenvatinib Following Liver Transplantation in Patients of Hepatocellular Carcinoma With Portal Vein Tumor Thrombus lenvatinib, Placebo - Hepatocellular Carcinoma, Portal Vein Tumor Thrombus | Phase 2 / Phase 3 | Unknown | RenJi Hospital | 108 | 2020-05-02 | 2020-03-24 |
| Relenvatinib in the Tatment of Recurrence of Hepatocellular Carcinoma After Liver Transplantation relenvatinib - Hepatocellular Carcinoma, Liver Transplantation | Phase 3 | Unknown | RenJi Hospital | 40 | 2020-05-01 | 2020-03-24 |
| Sirolimus-based Immunosuppression Treatment Regimen for Liver Transplantation Tacrolimus, Tacrolimus (Tacrolimus elimination), Sirolimus - Liver Transplantation | Phase 2 / Phase 3 | Unknown | Southern Medical University, China | 130 | 2018-05-01 | 2018-04-18 |
| De Novo Everolimus Versus Tacrolimus in Combination With Mofetil Mycophenolate and Low Dose Corticosteroids to Reduce Tacrolimus Induced Nephrotoxicity in Liver Transplantation: a Prospective, Multicentric, Randomised Study Tacrolimus, Everolimus, Mycophenolate mofetil - Liver Transplantation | Phase 3 | Withdrawn | Rennes University Hospital | 2016-11-01 | 2022-12-14 | |
| Pilot Study Evaluate Efficacy of Grazoprevir + Elbasvir for 12 or 16 Weeks in Liver Transplant Recipients. Grazoprevir 100 mg/day, Elbasvir 50 mg/d, Elbasvir 50 mg/day - Liver Transplantation, Hepatitis C | Phase 3 | Withdrawn | Fundacion Clinic per a la Recerca Biomédica | 2016-08-03 | 2025-06-22 | |
| Study to Evaluate Pharmacokinetic and Bioavailability of Envarsus® vs. Advagraf® in Liver Transplant Recipients Treatment 2 weeks Envarsus followed by 2 weeks Advagraf, Treatment 2 weeks Advagraf followed by 2 weeks Envarsus - Liver Transplantation | Phase 3 | Completed | Universitätsklinikum Hamburg-Eppendorf | 20 | 2016-05-01 | 2021-05-04 |
| Study of the Effect of Everolimus Immunosuppressive Combination Therapies on Renal Function When Used as a Maintenance Treatment for Liver Transplant Patients. TAC withdrawal, Everolimus with reduced TAC - Liver Transplantation | Phase 3 | Withdrawn | Novartis Pharmaceuticals | 2015-09-01 | 2018-07-24 | |
| REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategy Everolimus, Tacrolimus - Liver Transplantation | Phase 3 | Completed | Novartis Pharmaceuticals | 78 | 2014-03-28 | 2019-02-28 |
| Efficacy and Safety of Everolimus in Liver Transplant Recipients of Living Donor Liver Transplants Everolimus + reduced tacrolimus, Standard tacrolimus - Liver Transplantation | Phase 3 | Completed | Novartis Pharmaceuticals | 285 | 2013-09-25 | 2019-03-18 |
| A National Multi-center Randomized, Open Label Study to Evaluate Efficacy and Safety of Everolimus With EC-MPS Compared to Standard Treatment Combination Tacrolimus and EC-MPS in de Novo Liver Transplant Recipients tacrolimus, everolimus, Basiliximab - Liver Transplantation | Phase 3 | Completed | Novartis Pharmaceuticals | 188 | 2012-12-01 | 2016-04-27 |
| CNI-free "Bottom"-up Immunosuppression in Patients Undergoing Liver Transplantation delayed, low-dose CNI, BU-CNI, BU-Everolimus - Renal Impairment, Liver Transplantation | Phase 2 / Phase 3 | Unknown | University of Regensburg | 45 | 2011-06-01 | 2011-07-01 |
| Efficacy and Safety of Niuliva® for the Prevention of Hepatitis B Virus Recurrence in Newly Orthotopic Liver Transplant Recipients Hepatitis B immune globulin - Hepatitis B, Liver Transplantation | Phase 3 | Completed | Instituto Grifols, S.A. | 15 | 2010-07-01 | 2016-02-25 |
| Liver Transplant European Study Into the Prevention of Fungal Infection micafungin, fluconazole, liposomal amphotericin B - Liver Transplantation, Mycoses | Phase 3 | Completed | Astellas Pharma Inc | 350 | 2009-12-15 | 2024-11-18 |
| Phase 3b Study to Evaluate Advagraf in Combination With Mycophenolate Mofetil and Basiliximab in Liver Transplantation Advagraf, Mycophenolate Mofetil, Basiliximab - Liver Transplantation | Phase 3 | Completed | Astellas Pharma Inc | 893 | 2009-09-30 | 2024-11-01 |
| Pharmacokinetics of Tacrolimus in Liver Transplantation Patients Treated With Prograf and Modified Release Tacrolimus FK506E (modified release tacrolimus), Prograf (tacrolimus) - Liver Transplantation | Phase 3 | Completed | Astellas Pharma Inc | 10 | 2009-04-01 | 2010-04-16 |
| Surgical Site Infections After Liver Transplantation Based on Perioperative Antibiotics standard, extended, liver transplant - Liver Transplantation, Surgical Site Infection | Phase 3 | Completed | University of Virginia | 102 | 2009-03-01 | 2018-07-17 |
| The Effects of Glucose/Ischemic Preconditioning on Reperfusion Injury in Deceased-Donor Liver Transplantation Glucose/Ischemic Preconditioning Pre-treatment - Liver Transplantation | Phase 3 | Terminated | University Health Network, Toronto | 50 | 2008-08-01 | 2014-07-25 |
| Prevention of Hepatitis B Virus Reinfection After Liver Transplantation With Entecavir Entecavir - Liver Transplantation, Hepatitis B | Phase 3 | Completed | HepNet Study House, German Liverfoundation | 20 | 2008-03-01 | 2014-11-05 |
Showing 20 of 37. Sign in to see all of them.
Carcinoma, Hepatocellular (3) · Liver Diseases (3) · Hepatitis B (2) · Hepatitis C (2) · Bone Resorption (1) · Hepatitis C, Chronic (1) · Hereditary Sensory and Autonomic Neuropathies (1) · Infections (1) · Invasive Fungal Infections (1) · Liver Cirrhosis (1) · Mycoses (1) · Recurrence (1) · Reinfection (1) · Rejection, Psychology (1) · Renal Insufficiency (1)
Digestive System Diseases (10) · Infections (7) · Liver Diseases (7) · Blood-Borne Infections (5) · Communicable Diseases (5) · Hepatitis (5) · Hepatitis, Viral, Human (5) · Virus Diseases (5) · Adenocarcinoma (3) · Carcinoma (3) · Digestive System Neoplasms (3) · Flaviviridae Infections (3) · Liver Neoplasms (3) · Neoplasms (3) · Neoplasms by Histologic Type (3)
Tacrolimus (18) · Everolimus (9) · Mycophenolic Acid (7) · Basiliximab (4) · Cyclosporine (4) · Adrenal Cortex Hormones (3) · Ribavirin (3) · Methylprednisolone (2) · Sirolimus (2) · Steroids (2) · Alendronate (1) · Anti-Bacterial Agents (1) · Azathioprine (1) · Calcineurin Inhibitors (1) · Caspofungin (1)
Astellas Pharma Inc (10) · Novartis Pharmaceuticals (8) · RenJi Hospital (2) · Rennes University Hospital (2) · Astellas Pharma Europe Ltd. (1) · Columbia University (1) · Fundacion Clinic per a la Recerca Biomédica (1) · Hannover Medical School (1) · HepNet Study House, German Liverfoundation (1) · Instituto Grifols, S.A. (1) · Merck Sharp & Dohme LLC (1) · Novartis (1) · Southern Medical University, China (1) · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (1) · University Health Network, Toronto (1)
Germany (16) · Italy (11) · France (8) · Belgium (7) · Canada (7) · Spain (7) · Switzerland (7) · United Kingdom (7) · Sweden (6) · Czechia (5) · Hungary (5) · Ireland (5) · United States (5) · Austria (4) · Brazil (4)
Andreas A Schnitzbauer, MD (1) · Beicheng Sun, PhD，MD (1) · Elizabeth Shane, M.D. (1) · Hans J Schlitt, MD (1) · Heiner Wedemeyer, MD (1) · J. Langrehr (1) · Karim Boudjema, MD, PhD (1) · Kebo Zhong, M.D (1) · Markus Selzner, M.D. (1)
PMID 19497063, PMID 19790150, PMID 22739223, PMID 23024190, PMID 23714399, PMID 25520332, PMID 26151607, PMID 28295581, PMID 28817434, PMID 29237235, PMID 32799356
2008 (3), 2005 (2), 2015 (1), 2025 (1), T32AI078875 (1)