4 completed. 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Completed 4 |
Follow Lethargy: new trials by email Literature Review of Lethargy trials Research Report on Lethargy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Apathy in Dementia Methylphenidate Trial 2 Methylphenidate, Placebo - Apathy, Alzheimer's Disease | Phase 3 | Completed | Johns Hopkins Bloomberg School of Public Health | 200 | 2016-01-01 | 2023-06-13 |
| Monotherapy Brexpiprazole (OPC-34712) Trial in the Treatment of Adults With Early-Episode Schizophrenia Brexpiprazole - Schizophrenia | Phase 3 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 49 | 2013-11-01 | 2016-03-29 |
| Study of Rivastigmine to Treat Parkinsonian Apathy Without Dementia rivastigmine, placebo - Parkinson's Disease, Apathy | Phase 3 | Completed | University Hospital, Lille | 40 | 2009-03-01 | 2012-04-24 |
| Treatment of Apathy in Alzheimer's Disease With Modafinil Modafinil, Placebo - Apathy, Alzheimer's Disease | Phase 3 | Completed | Brown University | 22 | 2005-07-01 | 2011-03-04 |
Alzheimer Disease (2) · Caregiver Burden (1) · Mental Disorders (1) · Parkinson Disease (1) · Psychotic Disorders (1) · Schizophrenia (1)
Nervous System Diseases (4) · Neurobehavioral Manifestations (4) · Neurologic Manifestations (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Brain Diseases (3) · Central Nervous System Diseases (3) · Neurodegenerative Diseases (3) · Dementia (2) · Mental Disorders (2) · Neurocognitive Disorders (2) · Tauopathies (2) · Basal Ganglia Diseases (1) · Behavior (1) · Behavioral Symptoms (1)
Cholinesterase Inhibitors (1) · Methylphenidate (1) · Modafinil (1) · Rivastigmine (1) · Transdermal Patch (1) · brexpiprazole (1)
Brown University (1) · Johns Hopkins Bloomberg School of Public Health (1) · Otsuka Pharmaceutical Development & Commercialization, Inc. (1) · University Hospital, Lille (1)
United States (3) · Canada (1) · France (1)
David Devos, MD, PhD (1) · Jacobo Mintzer, MD (1) · Junichi Hashimoto, PhD (1) · Laura L Frakey, Ph.D. (1)
PMID 22687392, PMID 24218528, PMID 29347996, PMID 34570180, PMID 37066690, PMID 41521126
2008 (1), F32MH075583 (1), R01AG046543 (1)