11 completed, 3 unknown, 2 recruiting, 1 terminated. 9 Not applicable, 5 Phase 4, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 6, Unknown 2, Recruiting 1 |
| Phase 4 | 5 | Completed 2, Recruiting 1, Terminated 1, Unknown 1 |
| Phase 3 | 2 | Completed 2 |
Follow proxymetacaine: new trials by email Literature Review of proxymetacaine trials Research Report on proxymetacaine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison Between Outcomes of Closure of Idiopathic Macular Hole Using Autologus Tenon Capsule Graft and Internal Limiting Membrane Flap Techniques (Pilot Study) vitrectomy under topical anesthesia [Proparacaine HCL (Alcaine®)] - Macular Hole Surgery, ILM Peeling | Not applicable | Recruiting | Ain Shams University | 20 | 2025-11-09 | 2026-06-08 |
| A Study of Safety and the Local Anesthetic Effect of AG-920 Ophthalmic Solution in a Pediatric Population AG-920, Proparacaine Ophthalmic - Anesthesia, Local | Phase 3 | Completed | American Genomics, LLC | 61 | 2022-04-06 | 2023-10-25 |
| Wearing-Off Period of Pharmacological Dilation and Anisocoria Tropicamide, 1% Pilocarpine, Proparacaine Hydrochloride - Anisocoria | Phase 4 | Completed | Prisma Health-Upstate | 11 | 2022-04-01 | 2023-03-07 |
| Does Topical Ophthalmic Proparacaine 0.5% Prior to Probing and Irrigation Decrease Pain? Proparacaine Hydrochloride ophthalmic solution, USP 0.5%, Balanced salt solution - Epiphora, Dacryostenosis | Phase 4 | Recruiting | Louisiana State University Health Sciences Center in New Orleans | 145 | 2020-06-30 | 2022-12-23 |
| Does Topical Ophthalmic Anesthetic Prior to Probing and Irrigation Decrease Pain? Proparacaine Hydrochloride ophthalmic solution, USP 0.5%, Balanced salt solution - Epiphora, Dacryostenosis | Phase 4 | Terminated | Corewell Health East | 2 | 2020-06-30 | 2023-01-19 |
| Anesthetic Impregnated Bandage Soft Contact Lens (BSCL) in Pain Management After Photorefractive Keratectomy (PRK) Proparacaine Ophthalmic - Myopia, Hypermetropia | Phase 4 | Unknown | Beeran Meghpara, MD | 30 | 2020-06-01 | 2021-10-06 |
| Topical Proparacaine Eye Drops to Improve the Experience of Patients Undergoing Intravitreal Injections Proparacaine, Conjunctival culture - Age-related Macular Degeneration, Diabetic Macular Edema | Not applicable | Completed | Mayo Clinic | 36 | 2016-10-12 | 2023-04-12 |
| Comparison the Topical Anesthesia and Retrobulbar Anesthesia for 27-gauge Vitrectomy for Vitreous Floaters vitrectomy under topical anesthesia [Proparacaine HCL (Alcaine®)] - Perioperative Pain Experiences | Not applicable | Unknown | Lin Zhong | 30 | 2016-10-01 | 2017-02-09 |
| Comparing Ropivacaine and Bupivacaine in DTFNB Anesthesia in Patients Undergoing Phacoemulsification Deep Topical Fornix Nerve block anesthesia, Ropivacaine, Bupivacaine - Cataract Unilateral Pending Extraction, Anesthesia | Not applicable | Completed | Government Medical College, Haldwani | 100 | 2016-10-01 | 2017-01-25 |
| SPI-directed Analgesia for Vitreoretinal Surgeries Metamizol, Acetaminophen, 0,5 % bupivacaine with of 2% lidocaine - Vitreoretinal Surgeries, Postoperative Nausea and Vomiting | Not applicable | Completed | Medical University of Silesia | 176 | 2016-02-01 | 2018-01-23 |
| Laser Peripheral Iridotomy Plus Laser Peripheral Iridoplasty for Primary Angle Closure neodymium:yttrium-aluminum- garnet laser, frequency-doubled Q-switched neodymium:yttrium-aluminum-garnet 532-nm laser, Pilocarpine - Glaucoma, Angle-Closure | Not applicable | Unknown | Sun Yat-sen University | 240 | 2015-10-01 | 2018-09-06 |
| Subfoveal Choroidal Thickness After Surgery for Age-related Cataracts Femtosecond laser-assisted cataract surgery, Conventional phacoemulsification cataract surgery, Tropicamide - Cataract | Not applicable | Completed | Sun Yat-sen University | 40 | 2014-08-01 | 2016-09-09 |
| Comparison of Three Different Anesthetic Approaches for Intravitreal Injections Group Drops, Group SC, Group gel - Pain | Phase 4 | Completed | Retina Clinic, Sao Paulo, Brazil | 92 | 2014-06-01 | 2014-10-13 |
| Comparison of In-the-bag Stability Between Single-piece and Three-piece Intraocular Lens Phacomulsification lens removal cataract surgery with single-piece Intraocular lens(IOL) implantation, Phacomulsification lens removal cataract surgery with three-piece Intraocular lens(IOL) implantation, Subconjunctival dexamethasone - Cataract | Not applicable | Completed | Sun Yat-sen University | 65 | 2012-09-01 | 2015-11-20 |
| Anesthesia Preference for Intravitreal Injection: Topical or Subconjunctival Xylocaine 2% Injectable Anesthetic, Proparacaine Hydrochloride 0.5% Drop, Tetravisc 0.5% Gel - Age-related Macular Degeneration, Central Retinal Vein Occlusion | Not applicable | Completed | Retina Vitreous Associates of Florida | 57 | 2012-07-01 | 2014-04-21 |
| Strabismus Recovery With Proparacaine and Oculocardiac Reflex Topical Solution - Strabismus, Bradycardia | Completed | Alaska Blind Child Discovery | 140 | 2010-07-29 | 2020-10-19 | |
| Patient Assessment of Topical Anesthetic Effectiveness for Intravitreal Injections proparacaine HCL 0.5%, proparacaine HCL 0.5% + 4% lidocaine solution, 3.5% viscous lidocaine gel - Pain | Phase 3 | Completed | Illinois Retina Associates | 120 | 2009-10-01 | 2010-05-04 |
Pain (4) · Cataract (2) · Dacryocystitis (2) · Lacrimal Apparatus Diseases (2) · Lacrimal Duct Obstruction (2) · Macular Degeneration (2) · Pain, Postoperative (2) · Anisocoria (1) · Astigmatism (1) · Bradycardia (1) · Glaucoma, Angle-Closure (1) · Hyperopia (1) · Myopia (1) · Nausea (1) · Postoperative Nausea and Vomiting (1)
Sun Yat-sen University (3) · Ain Shams University (1) · Alaska Blind Child Discovery (1) · American Genomics, LLC (1) · Beeran Meghpara, MD (1) · Corewell Health East (1) · Government Medical College, Haldwani (1) · Illinois Retina Associates (1) · Lin Zhong (1) · Louisiana State University Health Sciences Center in New Orleans (1) · Mayo Clinic (1) · Medical University of Silesia (1) · Prisma Health-Upstate (1) · Retina Clinic, Sao Paulo, Brazil (1) · Retina Vitreous Associates of Florida (1)
United States (8) · China (4) · Brazil (1) · Egypt (1) · India (1) · Poland (1)
Haotian Lin, M.D., Ph.D (2) · Weirong Chen, M.D. (2) · Yizhi Liu, M.D., Ph.D (2) · Austin M Pharo, MD (1) · Beeran Meghpara, MD (1) · Dianne M Schlachter, MD (1) · Gabriel C Andrade, M.D. (1) · Govind S Titiyal, Professor (1) · John S. Pollack, MD (1) · Jose S Pulido, MD (1) · Martin Uram, MD (1) · Robert W Arnold, MD (1) · Steven M Cohen, MD (1)
PMID 19898665, PMID 10794256, PMID 11756886, PMID 12355695, PMID 12567343, PMID 15288990, PMID 15483476, PMID 16340529, PMID 16703549, PMID 17056383, PMID 17061223, PMID 17392852, PMID 17620596, PMID 17891002, PMID 18812132, PMID 19205490, PMID 21102369, PMID 21178659, PMID 22282296, PMID 22412772, PMID 23471754, PMID 23928675, PMID 24012235, PMID 24171832, PMID 24317292, PMID 24404359, PMID 24535604, PMID 25032676, PMID 25582785, PMID 27392024, PMID 28302178, PMID 29318039, PMID 29733898, PMID 29981573, PMID 38647654, PMID 7614283