14 completed, 1 withdrawn. 10 Phase 1, 9 Phase 2, 2 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 10 | Completed 10 |
| Phase 2 | 9 | Completed 8, Withdrawn 1 |
| Not applicable | 2 | Completed 2 |
| Phase 3 | 1 | Completed 1 |
Follow acyline: new trials by email Literature Review of acyline trials Research Report on acyline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ITT-5 Mechanisms of Spermatogenesis in Man Testosterone 1% Gel, Acyline, Dutasteride - Gonadotropin Deficiency | Phase 2 | Withdrawn | University of Washington | 2019-06-01 | 2019-12-18 | |
| Cardiovascular Outcomes of Low Testosterone Acyline, Placebo Gel, Placebo Tablet - Hypogonadism | Not applicable | Completed | University of Colorado, Denver | 232 | 2016-07-01 | 2024-10-10 |
| T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin Acyline, Testosterone 1.62% gel, Letrozole - Insulin Resistance, Type 2 Diabetes Mellitus | Phase 1 / Phase 2 | Completed | University of Washington | 53 | 2013-06-01 | 2018-05-08 |
| PROS-2 Dose Response Effects of Exogenous Testosterone on the Prostate placebo acyline, placebo gel, Testosterone 1% gel 1.25 g - Healthy | Phase 2 / Phase 3 | Completed | University of Washington | 62 | 2011-10-01 | 2017-10-05 |
| ITT4 Intratesticular Hormonal Milieu in Man (ITT4) Acyline, Testosterone gel, ketoconazole 400 - Healthy Males | Phase 1 / Phase 2 | Completed | University of Washington | 46 | 2011-01-01 | 2014-03-31 |
| ORAL T-8 Oral Testosterone for Male Hormonal Contraception Oral Testosterone, Acyline - Healthy | Phase 1 | Completed | University of Washington | 14 | 2010-07-01 | 2013-09-06 |
| HOP-3 Manipulation of the Intratesticular Hormonal Milieu With Exogenous Testosterone Acyline, placebo hCG (no active ingredient), hCG (human chorionic gonadotropin) - Healthy Males | Phase 1 / Phase 2 | Completed | University of Washington | 59 | 2009-03-01 | 2016-01-11 |
| CEP-1 Hormonal Regulation of Circulating Endothelial Progenitor Cells and HDL-C in Men Acyline, Acyline + Testosterone gel, Acyline + testosterone gel + anastrozole - Healthy | Phase 2 | Completed | University of Washington | 31 | 2008-12-01 | 2012-10-12 |
| ORAL T-6: Oral Androgens in Man-6 Acyline, Testosterone, Finasteride - Contraception, Hypogonadism | Phase 1 | Completed | University of Washington | 16 | 2008-10-01 | 2011-01-24 |
| ACY-7 Oral Administration of Acyline Acyline - Healthy | Phase 1 / Phase 2 | Completed | University of Washington | 4 | 2008-01-01 | 2011-06-09 |
| ACY-6 Oral Administration of Acyline Acyline - Contraception | Phase 1 | Completed | University of Washington | 9 | 2007-06-01 | 2010-12-03 |
| Manipulation of the Intratesticular Hormonal Milieu With Exogenous Testosterone (HOP 5) Testicular Aspiration Addendum Acyline, Testosterone Gel, Depo-Medroxyprogesterone - Contraception | Phase 1 / Phase 2 | Completed | University of Washington | 23 | 2004-12-01 | 2008-09-19 |
| The Effects of Testosterone on Prostate Tissue (ACYP-1) Testosterone gel, Acyline, Placebo acyline - Hypogonadism, Contraception | Phase 1 | Completed | University of Washington | 13 | 2004-07-01 | 2008-09-19 |
| Male Hormonal Contraceptive Development-ACY-5 Acyline, Testosterone Gel, Depo-Medroxyprogesterone - Contraception | Phase 1 / Phase 2 | Completed | University of Washington | 43 | 2004-05-01 | 2008-09-19 |
| Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men GnRH antagonist (Acyline) - Hypogonadism | Not applicable | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 40 | 2002-10-01 | 2011-04-20 |
Hypogonadism (5) · Insulin Resistance (2) · Diabetes Mellitus, Type 2 (1) · Kallmann Syndrome (1) · Metabolic Diseases (1) · Obesity (1)
University of Washington (13) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · University of Colorado, Denver (1)
United States (14)
William J Bremner, MD, PhD (3) · John K Amory (2) · Stephanie T Page, MD, PhD (2) · Frances J Hayes, MD (1) · John K Amory, MD (1) · John K Amory, MD, MPH (1) · Katya Rubinow, MD (1) · Kerrie Moreau, PhD (1) · Mara Roth, MD (1) · Mara Y Roth, MD (1) · Stephanie Page, MD, PhD (1) · William Bremner, MD (1) · William Bremner, MD, PhD (1) · William J Bremner, MD (1)
PMID 17494097, PMID 20378927, PMID 16352669, PMID 16882745, PMID 16940442, PMID 17303493, PMID 17510436, PMID 20484472, PMID 21797916, PMID 22266332, PMID 23040523, PMID 23348398, PMID 27172434, PMID 27482750, PMID 29793828
U54HD042454 (3), U54HD012629 (2), K23HD045386 (1), R01AG037603 (1), R01AG049762 (1)