8 not yet recruiting, 6 completed, 5 unknown, 3 recruiting. 13 Not applicable, 4 Phase 2, 4 Phase 3, 2 Phase 4, 1 Early Phase 1.
Follow Hypertrophic Scars: new trials by email Literature Review of Hypertrophic Scars trials Research Report on Hypertrophic Scars
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase II Clinical Study on Preliminary Efficacy and Safety of ETD-001 Gel for Hypertrophic Scars ETD-001 gel, Placebo - Hypertrophic Scars | Phase 2 | Not yet recruiting | Etern Therapeutics Wuxi Limited | 90 | 2027-02-28 | 2026-10-23 |
| Carbon Dioxide Laser-Assisted Delivery of Triamcinolone With or Without 5-Fluorouracil for Hypertrophic Burn Scars Fractional Ablative CO₂ Laser, Triamcinolone Acetonide, Fluorouracil (5-FU) - Burn, Hypertrophic Scars | Not applicable | Not yet recruiting | University of California, Davis | 65 | 2026-08-22 | 2026-08-24 |
| Scar Gel Product Family Clinical Investigation Dermatix, Dermatix Ultra - Hypertrophic Scars, Keloids | Not yet recruiting | Hanson Medical, Inc. | 150 | 2026-07-01 | 2026-07-06 | |
| Topical Cryotherapy and Keloid/Hypertrophic Scars Cryotherapy with liquid nitrogen, Intralesional Triamcinolone 10 mg/ml - Keloid Scars, Hypertrophic Scars | Phase 3 | Recruiting | Sonal Choudhary | 30 | 2026-06-10 | 2026-06-12 |
| Nano-Fat Grafting for Post-Burn Scars on the Chest, Shoulders, and Back Autologous Nano-Fat Grafting - Hypertrophic Scars, Post-burn Scars | Not applicable | Not yet recruiting | Assiut University | 55 | 2026-06-01 | 2026-04-29 |
| Surgical Care And Recovery With Laser Evaluation Trial (SCARLET) ProFractional Laser Therapy and/or Broadband Light (BBL) Treatment - Post-surgical Scars, Hypertrophic Scars | Not applicable | Not yet recruiting | AdventHealth | 150 | 2026-04-01 | 2026-01-22 |
| Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil Chitosan cream, Silicone Gel, Olive Oil Topical Oil - Hypertrophic Scars | Not applicable | Recruiting | Universiti Sains Malaysia | 120 | 2025-12-21 | 2026-01-02 |
| Evaluation of Clinical, Perceived and Instrumental Efficacy of a Scar Gel in Preventing Hypertrophic Scars Scar gel, Scar gel comparator - Acceptability Study, Real-use Conditions | Phase 1 / Phase 2 | Recruiting | Herbarium Laboratorio Botanico Ltda | 80 | 2025-04-03 | 2025-09-11 |
| Microporous Tape and Post Surgical Scars Microporous tape, Tradition physical therapy - Microporous Tape, Hypertrophic Scars | Not applicable | Not yet recruiting | Cairo University | 44 | 2025-01-07 | 2025-01-10 |
| Treatment of Hypertrophic Scars Using Fractional CO2 Laser Alone in Comparison With Adding Botulinum Toxin Either Through Intralesional Injection or Assisted Drug Delivery Botulinum toxin type A (Botox®, Allergan) - Hypertrophic Scars | Not applicable | Completed | Cairo University | 48 | 2025-01-01 | 2026-01-22 |
| Electromotive Drug Administration of Magnesium Sulphate on Hypertrophic Scar Magnesium Sulphate Iontophoresis, traditional physical therapy program - Hypertrophic Scars | Not applicable | Not yet recruiting | Cairo University | 80 | 2024-11-15 | 2024-10-18 |
| Effect of PRF & Fractional CO2 Laser in Postburn Hypertrophic Scars Plasma rich in growth factors (PRGF-Endoret), Fractional CO2 laser assisted PDT - Hypertrophic Scars, Burn Scar Patients | Early Phase 1 | Not yet recruiting | Assiut University | 30 | 2024-11-01 | 2024-10-29 |
| Using Skin Blood Flow to Measure the Effect of Different Doses of Negative Pressure Therapy Negative pressure therapy, NPT - Hypertrophic Scars | Not applicable | Completed | Asia University | 36 | 2022-05-11 | 2024-11-15 |
| Fractional Microneedling RF vs Intralesional Steroid With & Without Microneedling in Hypertrophic Scars Fractional Microneedling Radiofrequency, Intralesional Steroid Injection with and without Microneedling - Hypertrophic Scars | Not applicable | Unknown | Cairo University | 30 | 2020-05-10 | 2020-05-15 |
| Effect of Cryotherpy on Hypertrophic Scar cryotherapy (Gymna Cryoflow ICE-CT), Exercising, Positioning and splinting, Pressure Therapy and Massage - Hypertrophic Scars | Phase 2 / Phase 3 | Unknown | Zakria Mowafy | 60 | 2019-04-15 | 2020-08-31 |
| Laser Induced Bioengineered Remodeling of Thermally Injured Skin Trial CO2 laser treatment, PDL laser treatment, Usual care - Hypertrophic Scars | Not applicable | Withdrawn | University of North Carolina, Chapel Hill | 2016-12-01 | 2017-04-17 | |
| Comparison of Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars Laser coagulation, Laser w/o coagulation - Keloid, Hypertrophic Scars | Phase 2 | Withdrawn | Insel Gruppe AG, University Hospital Bern | 2016-05-01 | 2017-04-14 | |
| Treatment of Hypertrophic Scars Using Fractional Laser and Fractional Laser-assisted Topical Corticosteroid Delivery 0.05% Clobetasol propionate, Petrolatum gel, Fractional Erbium:Yag (2,940-nm) laser - Hypertrophic Scars | Phase 4 | Completed | Mahidol University | 24 | 2014-04-01 | 2015-07-01 |
| Gene Expression During Surgical Scar Remodeling by Fractional Photothermolysis Fraxel Repair - Fractional Laser treatment - Hypertrophic Scars | Not applicable | Withdrawn | Massachusetts General Hospital | 2013-05-01 | 2019-09-19 | |
| Scars After Central Venous Catheters Betamethason-17-valerate and fusidic acid, Fusidic Acid - Hypertrophic Scars, Keloids | Phase 3 | Unknown | Mette Møller Handrup | 60 | 2010-03-01 | 2014-02-12 |
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Cicatrix, Hypertrophic (25) · Keloid (9) · Cicatrix (3) · Burns (2) · Hypertrophy (1) · Neoplasms (1)
Fibrosis (25) · Pathologic Processes (25) · Pathological Conditions, Signs and Symptoms (25) · Cicatrix (22) · Collagen Diseases (9) · Connective Tissue Diseases (9) · Skin and Connective Tissue Diseases (9) · Wounds and Injuries (2) · Pathological Conditions, Anatomical (1)
Cryotherapy (2) · Silicone Gels (2) · Adrenal Cortex Hormones (1) · Botulinum Toxins, Type A (1) · Clobetasol (1) · Cosmetics (1) · Fluorouracil (1) · Fusidic Acid (1) · Intercellular Signaling Peptides and Proteins (1) · Laser Coagulation (1) · Lasers (1) · Lasers, Dye (1) · Massage (1) · Patient Positioning (1) · Percutaneous Collagen Induction (1)
Cairo University (4) · Mahidol University (3) · Assiut University (2) · AdventHealth (1) · Asia University (1) · Association of Dutch Burn Centres (1) · Catalysis SL (1) · Etern Therapeutics Wuxi Limited (1) · Hanson Medical, Inc. (1) · Herbarium Laboratorio Botanico Ltda (1) · Insel Gruppe AG, University Hospital Bern (1) · Kaohsiung Veterans General Hospital. (1) · Massachusetts General Hospital (1) · Mette Møller Handrup (1) · Sonal Choudhary (1)
Egypt (4) · Thailand (3) · Taiwan (2) · United States (2) · Brazil (1) · China (1) · Cuba (1) · Denmark (1) · Malaysia (1) · Netherlands (1)
Ahmed Ali, Assistant Proffesor (1) · Esther Middelkoop, PhD (1) · Fernanda H Sakamoto, MD, PhD (1) · Henrik Hasle, Professor (1) · Ian A Powelson, MD (1) · Kuei-Chang Hsu, surgeon (1) · Marwa Salah El-Mesidy, MD (1) · Maurice Adatto, MD (1) · Mohamed Makboul, Professor (1) · Omara Lemus, MD (1) · R.Rox Anderson, MD (1) · Scott Hultman, MD (1) · Sonal Choudhary (1)
PMID 10808705, PMID 10927682, PMID 11887386, PMID 12028527, PMID 12028528, PMID 12032371, PMID 12534517, PMID 12711943, PMID 15113289, PMID 15209788, PMID 16163087, PMID 16254707, PMID 16267427, PMID 16413399, PMID 16437463, PMID 16575391, PMID 16696385, PMID 17214728, PMID 2009067, PMID 21551963, PMID 24085055, PMID 33567135, PMID 34043867, PMID 3690373, PMID 6390045, PMID 6625526, PMID 7555106, PMID 8078236, PMID 9194888, PMID 9306778, PMID 9810992, PMID 9972711
2009 (1)