18 completed, 3 terminated, 3 unknown, 2 active not recruiting. 8 Not applicable, 7 Phase 3, 3 Phase 2, 2 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 4, Active not recruiting 2, Recruiting 1, Unknown 1 |
| Phase 3 | 7 | Completed 5, Terminated 2 |
| Phase 2 | 3 | Completed 3 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
| Phase 4 | 1 | Completed 1 |
Follow Hypercholesterolemia, Familial: new trials by email Literature Review of Hypercholesterolemia, Familial trials Research Report on Hypercholesterolemia, Familial
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Real-World Study of Long-Term Adherence and Persistence to Inclisiran, Evolocumab, and Alirocumab Cardiovascular Diseases, Atherosclerotic Cardiovascular Disease | Recruiting | Novartis Pharmaceuticals | 5995 | 2026-04-02 | 2026-07-15 | |
| Screening for Familial Hypercholesterolemia in Children blood sample - Hypercholesterolemia, Familial | Not applicable | Recruiting | Centre Hospitalier Universitaire, Amiens | 300 | 2025-01-02 | 2026-02-12 |
| PET Imaging of Inflammation and Lipid Lowering Study Inclisiran, 68Ga-DOTATATE PET-MRI, Colchicine - Hypercholesterolemia, Hypercholesterolemia, Familial | Not applicable | Unknown | University of Cambridge | 63 | 2023-03-20 | 2024-07-19 |
| Clinical Decision Support for Familial Hypercholesterolemia Clinical decision support - Hypercholesterolemia, Familial, Clinical Decision Support | Not applicable | Active not recruiting | University Hospital, Linkoeping | 472029 | 2022-12-06 | 2026-10-14 |
| Diet Quality and Coronary Artery Calcification in Adults With Heterozygous Familial Hypercholesterolemia Diet - Hypercholesterolemia, Familial, Calcification; Heart | Unknown | Laval University | 258 | 2021-07-01 | 2024-03-13 | |
| Genetic Testing and Motivational Counseling for FH Genetic Testing, Motivational Counseling, Lipid analysis - Hypercholesterolemia, Familial, Hypercholesterolemia, Familial, 1 | Not applicable | Active not recruiting | National Medical Research Center for Therapy and Preventive Medicine | 180 | 2020-06-15 | 2024-12-17 |
| Evaluating the Efficacy of Pediatric Lipid Screening Alerts Best Practice Alert, Health Maintenance Topic - Hypercholesterolemia, Hypercholesterolemia, Familial | Not applicable | Completed | Geisinger Clinic | 13340 | 2019-10-10 | 2023-11-07 |
| Expression of Pro- and Anti-inflammatory Cytokines During Anti-PCSK9 in Familial Hypercholesterolemia Evolocumab - Hypercholesterolemia, Familial | Phase 4 | Completed | Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado | 20 | 2019-01-01 | 2024-01-30 |
| Comparison of the Plasma Lipoprotein Apheresis Systems DIAMED and MONET vs. the Whole Blood Apheresis System DALI Lipoprotein Apheresis MONET and DALI, Lipoprotein Apheresis DIAMED and DALI - Hypercholesterolemia, Familial, Dyslipidemias | Not applicable | Completed | Fresenius Medical Care Deutschland GmbH | 20 | 2018-12-28 | 2022-07-28 |
| Subclinical Atherosclerosis in Patients With Familial Hypercholesterolemia Treated With Evolocumab® Evolocumab - Hypercholesterolemia, Familial | Unknown | Federico II University | 25 | 2017-12-01 | 2021-03-08 | |
| Prospective German Very High Cardiovascular Risk Patients Dyslipidemia Treatment Indication Registry PCSK9 Inhibitor [EPC], Standard lipid lowering therapy - Dyslipoproteinemias, Hypercholesterolemia, Familial | Completed | GWT-TUD GmbH | 1695 | 2017-05-18 | 2025-05-09 | |
| Regeneron 1331 Kinetics Sub-Study HoFH Kinetics test - Hypercholesterolemia, Familial | Not applicable | Completed | University of Pennsylvania | 4 | 2016-10-07 | 2021-05-17 |
| Screening Protocol for a Gene Therapy Trial in Subjects With Homozygous Familial Hypercholesterolemia Hypercholesterolemia, Familial | Completed | University of Pennsylvania | 21 | 2016-03-01 | 2020-03-06 | |
| Is Family Screening Improved by Genetic Testing of Familial Hypercholesterolemia Standard of Care, Genetic Testing - Hypercholesterolemia, Familial | Not applicable | Completed | University of Pennsylvania | 240 | 2014-11-01 | 2020-12-10 |
| A Study of Extended-release (ER) Niacin/Laropiprant in Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0524A-158) MK-0524A - Hypercholesterolemia, Familial, Heterozygous Familial Hypercholesterolemia | Phase 1 | Terminated | Merck Sharp & Dohme LLC | 10 | 2012-06-01 | 2015-11-03 |
| Safety and Efficacy of the DALI LDL-adsorber and MONET Lipoprotein Filter DALI-adsorber, MONET-Lipoprotein filter - Hypercholesterolemia, Familial, LIPOPROTEIN TYPES--Lp SYSTEM Lp(a) HYPERLIPOPROTEINEMIA | Completed | Fresenius Medical Care Deutschland GmbH | 108 | 2012-05-01 | 2015-09-04 | |
| Study to Assess the Tolerability and Efficacy of Anacetrapib (MK-0859) Co-Administered With Statin in Participants With Heterozygous Familial Hypercholesterolemia (MK-0859-020) Anacetrapib, Placebo - Hyperlipoproteinemia Type II, Hypercholesterolemia, Familial | Phase 3 | Completed | Merck Sharp & Dohme LLC | 306 | 2012-02-03 | 2019-10-14 |
| Reduction of Low-Density Lipoprotein Cholesterol (LDL-C) With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study Evolocumab, Placebo - Hypercholesterolemia, Familial | Phase 2 | Completed | Amgen | 168 | 2011-08-02 | 2022-11-15 |
| Bone Marrow Stem Cells as a Source of Allogenic Hepatocyte Transplantation in Homozygous Familial Hypercholesterolemia Cellular transplantation - Hypercholesterolemia, Familial | Phase 1 | Completed | University of Tehran | 1 | 2007-06-01 | 2008-08-29 |
| Carotid IMT (Intima Media Thickening) Study (0524A-041)(TERMINATED) Comparator: niacin (+) laropiprant (MK0524A), Comparator: placebo - Hypercholesterolemia, Familial | Phase 3 | Terminated | Merck Sharp & Dohme LLC | 937 | 2006-09-01 | 2015-09-30 |
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Hyperlipoproteinemia Type II (28) · Cardiovascular Diseases (4) · Hypercholesterolemia (4) · Homozygous Familial Hypercholesterolemia (3) · Atherosclerosis (2) · Coronary Disease (2) · Dyslipidemias (2) · Heart Diseases (2) · Hypercholesterolemia, Autosomal Dominant, 3 (2) · Hyperlipidemias (2) · Calcinosis (1) · Carotid Stenosis (1) · Diabetes Mellitus (1) · Feeding Behavior (1) · Hyperlipidemia, Familial Combined (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (28) · Genetic Diseases, Inborn (28) · Hyperlipoproteinemias (28) · Lipid Metabolism Disorders (28) · Metabolic Diseases (28) · Metabolism, Inborn Errors (28) · Nutritional and Metabolic Diseases (28) · Lipid Metabolism, Inborn Errors (27) · Dyslipidemias (26) · Hyperlipidemias (26) · Vascular Diseases (4) · Arterial Occlusive Diseases (2) · Arteriosclerosis (2) · Behavior (2) · Pathological Conditions, Signs and Symptoms (2)
evolocumab (4) · Atorvastatin (3) · torcetrapib (3) · Diet (2) · Genetic Testing (2) · MK-0524 (2) · Niacin (2) · mipomersen (2) · ALN-PCS (1) · Blood Specimen Collection (1) · Cholestyramine Resin (1) · Colchicine (1) · Colesevelam Hydrochloride (1) · Ezetimibe (1) · Fatty Acids, Omega-3 (1)
Merck Sharp & Dohme LLC (3) · Pfizer (3) · University of Pennsylvania (3) · Fresenius Medical Care Deutschland GmbH (2) · Kastle Therapeutics, LLC (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · Amgen (1) · Centre Hospitalier Universitaire, Amiens (1) · Federico II University (1) · GWT-TUD GmbH (1) · Geisinger Clinic (1) · Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (1) · Laval University (1) · National Medical Research Center for Therapy and Preventive Medicine (1) · Novartis Pharmaceuticals (1)
United States (8) · Canada (4) · Netherlands (4) · France (3) · Germany (3) · South Africa (3) · Italy (2) · Sweden (2) · Australia (1) · Czechia (1) · Denmark (1) · Finland (1) · Iceland (1) · Iran (1) · Mexico (1)
Marina Cuchel, MD, PhD (2) · Alexandra Ershova, MD, PhD (1) · Alexey Meshkov, MD, PhD (1) · Amir Goren, PhD (1) · Andreas Birkenfeld, MD, PhD (1) · Bernd Hohenstein, MD, PhD (1) · Daniel J Rader, MD (1) · David Pittrow, MD, PhD (1) · Eberhard Roeseler, MD, Prof (1) · Elisabeth Steinhagen-Thiessen, MD, PhD (1) · Frank Leistikow, MD (1) · Franz Heigl, MD (1) · Frido Himmelsbach, MD (1)
PMID 17387131, PMID 17407645, PMID 19029469, PMID 20228610, PMID 20645885, PMID 21613319, PMID 33691480, PMID 34040191, PMID 34991937, PMID 36178485, PMID 37801454, PMID 38401785, PMID 40270128, PMID 40760109
2005 (1), R01HL031497 (1)