6 completed, 1 not yet recruiting, 1 withdrawn. 3 Not applicable, 1 Phase 1, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Completed 3 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Not yet recruiting 1 |
| Phase 4 | 1 | Completed 1 |
Follow Human African Trypanosomiasis: new trials by email Literature Review of Human African Trypanosomiasis trials Research Report on Human African Trypanosomiasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stop Transmission of Gambiense Human African Trypanosomiasis (STROgHAT) Treatment of seropositive individuals (positive serology test, but parasitology not confirmed) - Human African Trypanosomiasis | Phase 3 | Not yet recruiting | Drugs for Neglected Diseases | 2500 | 2024-04-08 | 2024-04-10 |
| Assessment of Recombinant HAT-RDT Specificity Human African Trypanosomiasis | Completed | Institute of Tropical Medicine, Belgium | 1504 | 2022-09-20 | 2023-09-28 | |
| Prospective Evaluation of the Specificity of Serological Tests for Human African Trypanosomiasis Serological field test for HAT, malaria rapid test, Immunologic laboratory tests - Human African Trypanosomiasis, Sleeping Sickness | Not applicable | Completed | Institut de Recherche pour le Developpement | 1095 | 2022-06-20 | 2024-04-05 |
| Prospective Evaluation of an RDT to Screen for Gambiense HAT and Diagnose P. Falciparum Malaria No intervention - Human African Trypanosomiasis | Withdrawn | Foundation for Innovative New Diagnostics, Switzerland | 2022-01-31 | 2024-01-09 | ||
| Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP3 Post Elimination Monitoring Rapid diagnostic test (RDT); Serological and molecular tests on DBS - Human African Trypanosomiasis, Sleeping Sickness | Not applicable | Completed | Institut de Recherche pour le Developpement | 13747 | 2019-09-01 | 2022-04-15 |
| Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) rk28 ICT, IT LEISH (rK39), Immunochromatographic HAT test - Visceral Leishmaniasis, Human African Trypanosomiasis | Not applicable | Completed | University Hospital, Geneva | 1927 | 2013-01-01 | 2016-10-27 |
| Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the Fexinidazole Fexinidazole/Placebo - Human African Trypanosomiasis | Phase 1 | Completed | Drugs for Neglected Diseases | 108 | 2009-09-01 | 2017-04-06 |
| Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine (NECT) for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis (HAT) in the Meningo-encephalitic Phase Nifurtimox-Eflronithine Combination Treatment (NECT) - Human African Trypanosomiasis | Phase 4 | Completed | Drugs for Neglected Diseases | 630 | 2009-04-01 | 2013-05-31 |
Trypanosomiasis, African (3) · Disease (2) · Infections (2) · Neglected Diseases (2) · Brucellosis (1) · Hypersensitivity (1) · Leishmaniasis, Visceral (1) · Leptospirosis (1) · Liver Abscess, Amebic (1) · Malaria (1) · Melioidosis (1) · Relapsing Fever (1) · Rickettsia Infections (1) · Trypanosomiasis (1) · Tuberculosis (1)
Euglenozoa Infections (4) · Parasitic Diseases (4) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Protozoan Infections (4) · Vector Borne Diseases (4) · Disease Attributes (2) · Infections (2) · Trypanosomiasis (2) · Abdominal Abscess (1) · Abscess (1) · Actinomycetales Infections (1) · Amebiasis (1) · Bacterial Infections (1) · Bacterial Infections and Mycoses (1)
Eflornithine (1) · Nifurtimox (1) · Rapid Diagnostic Tests (1) · fexinidazole (1)
Drugs for Neglected Diseases (3) · Institut de Recherche pour le Developpement (2) · Foundation for Innovative New Diagnostics, Switzerland (1) · Institute of Tropical Medicine, Belgium (1) · University Hospital, Geneva (1)
Democratic Republic of the Congo (3) · Côte d’Ivoire (2) · Burkina Faso (1) · Cambodia (1) · France (1) · Guinea (1) · Nepal (1) · Republic of the Congo (1) · Sudan (1)
Elena Nicco, MD (1) · Epco Hasker, Phd PH (1) · Johannes Blum, MD (1) · Lionel Hovsepian, MD (1) · Martial N'Djetchi Kassi (1) · Nathalie Strub-Wourgaft, MD (1) · Oumou Camara (1) · Veerle Lejon, PhD, HDR (1) · Victor Kande, MD (1)
PMID 23209861, PMID 27812090, PMID 31986140, PMID 34748572, PMID 35491421, PMID 38978124, PMID 40191624, PMID 41351066