9 recruiting, 6 not yet recruiting, 5 completed, 5 terminated. 19 Phase 1, 9 Phase 2, 4 Not applicable, 2 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG) ADI-PEG 20 (Arginine deiminase pegylated), Temozolomide (TMZ), Standard of Care Radiation Therapy (RT) - Glioblastoma, High-Grade Glioma (WHO III-IV) | Phase 1 / Phase 2 | Not yet recruiting | Sabine Mueller, MD, PhD | 97 | 2027-06-01 | 2026-09-15 |
| IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG) Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells - High-grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 1 | Not yet recruiting | University of Florida | 24 | 2026-11-01 | 2026-09-09 |
| A Study on the Novel Oncolytic Virus Combined With PD-1 Inhibitor in the Treatment of Recurrent High-grade Glioma Novel oncolytic virus Ad-TD-nsIL12（BioTTT001） - High-grade Glioma | Phase 1 | Not yet recruiting | Beijing Bio-Targeting Therapeutics Technology Co., Ltd | 15 | 2026-07-31 | 2026-07-14 |
| Integrating Biology for Safe Intensification of Glioblastoma Hypofractionated Treatment on the MR-Linac MR-Linac System, Radiation Therapy, Temozolomide - High-grade Glioma | Phase 1 | Not yet recruiting | NYU Langone Health | 20 | 2026-06-01 | 2026-03-09 |
| APT-weighted and Diffusion MRI for Characterizing Tumor Infiltration in High-Grade Gliomas Standard-of-care MRI data, including APT and diffusion imaging, will be analyzed to generate quantitative maps of tumor infiltration within the peri-tumoral region. - High-Grade Glioma, Glioblastoma | Not yet recruiting | IRCCS Ospedale San Raffaele | 20 | 2026-04-01 | 2026-04-15 | |
| Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma Dual-target CAR-NK cells, Cyclophosphamide, Fludarabine - Glioblastoma, High-grade Glioma | Phase 1 | Recruiting | Beijing Biotech | 36 | 2026-02-02 | 2026-03-18 |
| Concurrent XRD-0394 With Radiation Therapy for High Grade Gliomas XRD-0394, Radiation Therapy, Surgical Resection - High-Grade Glioma | Early Phase 1 | Recruiting | NYU Langone Health | 39 | 2025-11-05 | 2026-01-02 |
| HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma Biological G207 - Neoplasms, High Grade Glioma | Phase 2 | Withdrawn | Pediatric Brain Tumor Consortium | 2025-09-01 | 2026-02-10 | |
| Atovaquone Combined With Radiation in Children With Malignant Brain Tumors Atovaquone, Radiation Therapy - High-grade Glioma, Medulloblastoma | Phase 1 | Recruiting | Emory University | 18 | 2025-03-28 | 2026-08-03 |
| Concurrent Azeliragon With Craniospinal Irradiation Azeliragon, CSI - Solid Tumor, High-grade Glioma | Phase 1 | Active not recruiting | NYU Langone Health | 21 | 2025-02-18 | 2026-05-18 |
| Clinical Study of Carbon Ion Radiotherapy for High-grade Glioma Carbon ion combined with photon radiotherapy - Carbon Ion Radiotheray, High-grade Glioma | Not applicable | Recruiting | Gansu Wuwei Tumor Hospital | 23 | 2025-02-01 | 2025-02-18 |
| Study of MT027 in Patients with Recurrent or Progressive High-grade Glioma MT027 cells suspension - High-grade Glioma | Phase 1 | Not yet recruiting | Suzhou Maximum Bio-tech Co., Ltd. | 12 | 2025-01-01 | 2024-12-17 |
| Safety and Efficacy Study of TX103 CAR-T Cell Therapy for Recurrent or Progressive Grade 4 Glioma. Anti-B7-H3 Chimeric Antigen Receptor T-Cell (CAR-T Cell) Injection/TX103 - High-grade Glioma, WHO Grade Ⅳ Glioma | Phase 1 | Recruiting | Tcelltech Inc. | 52 | 2024-09-04 | 2026-03-24 |
| A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors 68Ga-PSMA-11 PET Scans - High-grade Glioma, Brain Metastases | Early Phase 1 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 11 | 2024-01-05 | 2025-12-03 |
| Study of Adaptive Radiotherapy for High-grade Glioma Based on Interfraction MRI adaptive radiotherapy - High-grade Glioma | Unknown | West China Hospital | 60 | 2024-01-01 | 2024-01-11 | |
| Novel Targeted Radiotherapy in Pediatric Patients With Inoperable Relapsed or Refractory HGG CLR 131 - High-Grade Glioma | Phase 1 | Active not recruiting | Cellectar Biosciences, Inc. | 50 | 2023-10-01 | 2026-10-01 |
| Multi-Dimensional MRI Spatial Heterogeneity Analysis for Predicting Key Genes and Prognosis of High-Grade Gliomas: A Multi-Center Study MR scanning; Clinical data collection - High-grade Glioma | Recruiting | RenJi Hospital | 500 | 2023-09-01 | 2025-08-08 | |
| Multispectral Bimodal Fluorescence Guided Surgery of High-grade Glioma With Cetuximab-800CW and 5-ALA (5-aminolevulinic Acid) Cetuximab-IRDye800 - Glioblastoma, High-grade Glioma | Phase 1 | Unknown | University Medical Center Groningen | 21 | 2023-05-05 | 2023-07-03 |
| Study of Safety and Pharmacokinetic Properties of Oral OKN-007 in Patients with Recurrent High-Grade Glioma Low-dose OKN-007, BID, Low-dose OKN-007, TID, Mid-dose OKN-007, TID - High-grade Glioma, Oligodendroglioma | Phase 1 | Active not recruiting | Oblato, Inc. | 16 | 2023-04-17 | 2024-11-29 |
| Surgical Suction Aspirates Fluorescence Measurement Gliomas, High-grade Glioma | Recruiting | Kuopio University Hospital | 25 | 2023-02-07 | 2024-12-16 |
Showing 20 of 35. Sign in to see all of them.
Glioma (35) · Glioblastoma (11) · Brain Neoplasms (5) · Astrocytoma (3) · Diffuse Intrinsic Pontine Glioma (3) · Neoplasms (3) · Medulloblastoma (2) · Melanoma (2) · Recurrence (2) · Ependymoma (1) · Head and Neck Neoplasms (1) · Herpes Simplex (1) · Leukemia (1) · Leukemia, B-Cell (1) · Lung Neoplasms (1)
Neoplasms by Histologic Type (35) · Neoplasms, Germ Cell and Embryonal (35) · Neoplasms, Glandular and Epithelial (35) · Neoplasms, Nerve Tissue (35) · Neoplasms, Neuroepithelial (35) · Neuroectodermal Tumors (35) · Neoplasms (32) · Neoplasms by Site (11) · Nervous System Diseases (9) · Astrocytoma (8) · Central Nervous System Neoplasms (8) · Nervous System Neoplasms (8) · Brain Diseases (7) · Central Nervous System Diseases (7) · Brain Stem Neoplasms (3)
Temozolomide (4) · Radiotherapy (3) · ADI PEG20 (1) · AH 111585 (1) · Atovaquone (1) · BID protein, human (1) · CLR1404 (1) · Carboplatin (1) · Carmustine (1) · Cisplatin (1) · Crizotinib (1) · Cyclophosphamide (1) · Dasatinib (1) · Diffusion Magnetic Resonance Imaging (1) · Erlotinib Hydrochloride (1)
NYU Langone Health (3) · Amsterdam UMC, location VUmc (1) · Beijing Bio-Targeting Therapeutics Technology Co., Ltd (1) · Beijing Biotech (1) · Bristol-Myers Squibb (1) · Cellectar Biosciences, Inc. (1) · Copenhagen University Hospital, Rigshospitalet (1) · Emory University (1) · GE Healthcare (1) · Gansu Wuwei Tumor Hospital (1) · Hospital del Rio Hortega (1) · IRCCS Ospedale San Raffaele (1) · Jasper Gerritsen (1) · Kuopio University Hospital (1) · Laminar Pharmaceuticals (1)
United States (17) · China (9) · France (3) · Germany (3) · Netherlands (3) · Australia (2) · Spain (2) · Belgium (1) · Canada (1) · Denmark (1) · Finland (1) · Italy (1) · Switzerland (1)
Jonathan Yang, MD, PhD (3) · Allen K Sills, MD (1) · Anna Vinitsky, MD (1) · Anton Nosov, MD (1) · Antti-Pekka Elomaa, Docent (1) · Dirk Rades, MD (1) · Fernandez Philippe, Dr (1) · Gangxiong Huang, MD (1) · Gregory Friedman, MD (1) · Jarrod Longcor (1) · Jasper Gerritsen, MD PhD (1) · Jeffrey Winick, Ph.D. (1) · John Ligon, MD (1)
PMID 29245310, PMID 33836671, PMID 34286624, PMID 34586478, PMID 35165100, PMID 38413458, PMID 42675793
UM1CA081457 (1)