19 recruiting, 11 completed, 7 not yet recruiting, 1 active not recruiting. 12 Phase 2, 11 Phase 1, 10 Not applicable, 4 Phase 3, 1 Early Phase 1.
Follow Head & Neck Cancer: new trials by email Literature Review of Head & Neck Cancer trials Research Report on Head & Neck Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Radiotherapy In a Sitting Position for Enhanced Reproducibility Simulation of radiotherapy session in sitting position - Head & Neck Cancer | Not applicable | Not yet recruiting | Centre Leon Berard | 16 | 2026-12-31 | 2026-10-21 |
| Integrated Early-CARE for Head & Neck Cancer. Early palliative care integration - Head & Neck Cancer, Locally Advanced Head and Neck Cancer | Not applicable | Not yet recruiting | Portuguese Oncology Institute, Coimbra | 64 | 2026-10-01 | 2026-06-26 |
| A Master Regulator of Lipid-Associated Macrophage Function in Cancer Breast Cancer, Head & Neck Cancer | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 120 | 2026-10-01 | 2026-09-29 | |
| Nimotuzumab Plus Radiotherapy in Elderly Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Nimotuzumab - Head & Neck Cancer, Radiotherapy | Phase 2 | Not yet recruiting | Ke Hu | 46 | 2026-09-10 | 2026-09-15 |
| A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of the Peptide Drug Conjugate (PDC), TS-104, as a Monotherapy in Subjects With Select Advanced Solid Tumors TS-104 - NSCLC (Non-small Cell Lung Cancer), HNSCC | Phase 1 | Recruiting | TwoStep Therapeutics, Inc. | 74 | 2026-09-02 | 2026-09-30 |
| Penpulimab Combined With Chemotherapy for Patients With Locally Advanced Hypopharyngeal Carcinoma Finotonlimab, Nab-paclitaxel, carboplatin - Head & Neck Cancer | Phase 2 | Not yet recruiting | Tang-Du Hospital | 15 | 2026-08-23 | 2026-08-07 |
| Photobiomodulation Alone Versus Photobiomodulation Combined With Topical Oral Oxygen Therapy for Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Randomized Clinical Trial sirolase xtent laser, blue m gel - Mucositis Oral, Head & Neck Cancer | Phase 1 / Phase 2 | Enrolling by invitation | Assiut University | 46 | 2026-08-15 | 2026-10-08 |
| SL-28 for Advanced Solid Tumours SL-28 - Head & Neck Cancer, Pancreas Carcinoma | Phase 1 / Phase 2 | Recruiting | Second Life Therapeutics | 60 | 2026-08-14 | 2026-09-15 |
| Feasibility Study on the Implementation of a Supervised, Home-based Adapted Physical Activity Program for Patients With Head and Neck Cancer physical activity program - Head & Neck Cancer | Not applicable | Recruiting | Centre Henri Becquerel | 66 | 2026-07-22 | 2026-07-23 |
| A Clinical Study to Compare BupiZenge With Lidocaine for Pain Due to Oral Mucositis in Patients With Head and Neck Cancer. BupiZenge 25 mg, Lidocaine viscous 2% - Head & Neck Cancer, Oral Mucositis | Phase 3 | Recruiting | OncoZenge AB | 150 | 2026-07-07 | 2026-10-13 |
| Protein Supplementation for Radiation- Induced Oral Mucositis in Head and Neck Cancer Patients Receiving Radiotherapy Hydrolyzed Whey Protein Oral Supplement, Control - Head & Neck Cancer | Not applicable | Not yet recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 504 | 2026-07-01 | 2026-04-15 |
| REPROton-HN: Prospective Observational Study on Proton Re-irradiation for Locoregional Recurrences of Head and Neck Tumors Head & Neck Cancer | Recruiting | Istituto Clinico Humanitas | 50 | 2026-05-29 | 2026-06-09 | |
| Vebectotamab Vedotin Combined With Pucotelimab in the Treatment of Locally Advanced Laryngeal Carcinoma Vibecotamab Injection - Head & Neck Cancer | Phase 1 / Phase 2 | Not yet recruiting | Tang-Du Hospital | 10 | 2026-04-23 | 2026-04-20 |
| Nimotuzumab Combined With Immunotherapy and Chemotherapy in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma Nimotuzumab Injection, Tislelizumab, Albumin-Bound Paclitaxel /nab-Paclitaxel - Head and Neck Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma (HNSCC) | Phase 2 | Recruiting | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 182 | 2026-04-20 | 2026-07-09 |
| The Safety, Dosimetry and Efficacy of 177Lu-INN805 in Patients With Malignant Solid Tumors INN805 - Maligant Solid Tumor, Head & Neck Cancer | Early Phase 1 | Recruiting | FindCure Biosciences (ZhongShan) Co., Ltd. | 10 | 2026-04-20 | 2026-09-04 |
| Intratumoral Injection of Recombinant Human Endostatin Adenovirus (EDS01) for the Treatment of Recurrent or Metastatic Head and Neck Tumors EDS01 1.0×10^11 VP + Toripalimab, EDS01 5.0×10^11 VP + Toripalimab, EDS01 1.0×10^12 VP + Toripalimab - Head & Neck Cancer, Nasopharyngeal Cancinoma (NPC) | Phase 1 | Recruiting | West China Hospital | 9 | 2026-03-27 | 2026-09-02 |
| Postoperative Radiotherapy Combined With Nimotuzumab Followed by Benmelstobart in High-Risk Patients With Head and Neck Squamous Cell Carcinoma Bemcentinib, Nimotuzumab, radiotherapy - Head & Neck Squamous Cell Carcinoma, Head & Neck Cancer | Phase 3 | Recruiting | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 370 | 2026-03-04 | 2026-04-17 |
| Improving Dental Care for Patients With Head and Neck Tumors Educational material, - Oral Health Care, Oral Health Behavior Change | Not applicable | Recruiting | University Medical Center Goettingen | 134 | 2026-01-13 | 2026-09-09 |
| Compare Radiotherapy Plus Nimotuzumab Versus Radiotherapy Alone in Platinum-ineligible Patients With Locoregionally Advanced Head and Neck Squamous Cell Carcinoma Nimotuzumab, intensity-modulated technique（IMRT） - Head & Neck Squamous Cell Carcinoma, Head & Neck Cancer | Phase 3 | Recruiting | Shandong Cancer Hospital and Institute | 335 | 2026-01-05 | 2026-01-12 |
| A Phase 1b/2 Study of the Safety and Efficacy of the Monoclonal Antibody OM-RCA-01 in Patients With Metastatic Tumors Expressing Fibroblast Growth Factor Receptor 1 humanized monoclonal anti-FGFR1 antibody OM-RCA-01 - Renal Cell Carcinoma Metastatic, Prostate Cancer Metastatic | Phase 1 / Phase 2 | Recruiting | Kidney Cancer Research Bureau | 58 | 2025-12-02 | 2026-01-21 |
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Head and Neck Neoplasms (40) · Squamous Cell Carcinoma of Head and Neck (7) · Breast Neoplasms (5) · Esophageal Neoplasms (5) · Carcinoma, Non-Small-Cell Lung (3) · Endometrial Neoplasms (3) · Lung Neoplasms (3) · Melanoma (3) · Neoplasms (3) · Pathologic Complete Response (3) · Prostatic Neoplasms (3) · Carcinoma, Squamous Cell (2) · Colorectal Neoplasms (2) · Kidney Neoplasms (2) · Neoplasm Metastasis (2)
Neoplasms by Site (40) · Neoplasms (37) · Neoplasms by Histologic Type (13) · Neoplasms, Glandular and Epithelial (11) · Carcinoma (10) · Carcinoma, Squamous Cell (7) · Digestive System Diseases (7) · Digestive System Neoplasms (7) · Pathological Conditions, Signs and Symptoms (7) · Skin Diseases (7) · Skin and Connective Tissue Diseases (7) · Breast Diseases (6) · Gastrointestinal Diseases (6) · Gastrointestinal Neoplasms (6) · Pathologic Processes (6)
nimotuzumab (5) · 130-nm albumin-bound paclitaxel (3) · Carboplatin (3) · Albumin-Bound Paclitaxel (2) · Cisplatin (2) · Docetaxel (2) · Neoadjuvant Therapy (2) · toripalimab (2) · AH 111585 (1) · Cetuximab (1) · Chemoradiotherapy (1) · Everolimus (1) · Panobinostat (1) · Radiotherapy (1) · Radiotherapy, Intensity-Modulated (1)
Memorial Sloan Kettering Cancer Center (3) · Tang-Du Hospital (3) · Centre Henri Becquerel (2) · Novartis Pharmaceuticals (2) · Ain Shams University (1) · Assiut University (1) · Bristol-Myers Squibb (1) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (1) · Case Comprehensive Cancer Center (1) · Centre Leon Berard (1) · Dana-Farber Cancer Institute (1) · European Institute of Oncology (1) · FindCure Biosciences (ZhongShan) Co., Ltd. (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · GE Healthcare (1)
China (10) · United States (9) · Italy (5) · France (3) · Egypt (2) · Germany (2) · Japan (2) · Australia (1) · Belgium (1) · Canada (1) · Denmark (1) · Netherlands (1) · Norway (1) · Portugal (1) · Russia (1)
DaQing Zhao (1) · David Pfisher, MD (1) · David Pfister, MD (1) · Elise Carpentier (1) · Elisha Fredman, MD (1) · Geoffrey Shapiro, MD (1) · Gianluca Franceschini (1) · Giselle Carnaby-Mann, PhD (1) · Jeffrey Winick, Ph.D. (1) · Li-Yuan Bai, PhD (1) · Lise-Marie Roussel, MD (1) · Man Hu (1)
PMID 24496920, PMID 35131875, PMID 35339025, PMID 41117518, PMID 42523785
2014 (1), 2025 (1)