8 completed. 8 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Completed 8 |
| Phase 2 | 1 | Completed 1 |
Follow Granuloma: new trials by email Literature Review of Granuloma trials Research Report on Granuloma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Intravenous Efzofitimod in Patients With Pulmonary Sarcoidosis Efzofitimod 3 mg/kg, Efzofitimod 5 mg/kg, Placebo - Pulmonary Sarcoidosis | Phase 3 | Completed | aTyr Pharma, Inc. | 268 | 2022-09-15 | 2026-06-04 |
| Study of Mepolizumab-based Regimen Compared to Conventional Therapeutic Strategy in Patients With Eosinophilic Granulomatosis With Polyangiitis (E-merge) Mepolizumab, cyclophosphamide/azathioprine, Placebo - Eosinophilic Granulomatosis With Polyangiitis | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 102 | 2022-05-30 | 2026-10-01 |
| Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. Rituximab, Azathioprine, Placebo-rituximab - Eosinophilic Granulomatosis With Polyangiitis | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 98 | 2018-03-07 | 2025-11-20 |
| Rituximab in Eosinophilic Granulomatosis With Polyangiitis Rituximab, Placebo-rituximab, Cyclophosphamide - Eosinophilic Granulomatosis With Polyangiitis (EGPA) | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 107 | 2016-12-05 | 2026-01-15 |
| Long-term Access Program (LAP) of Mepolizumab for Subjects Who Participated in Study MEA115921 Mepolizumab, Prednisolone - Churg-Strauss Syndrome, Eosinophilic Granulomatosis With Polyangiitis | Phase 3 | Completed | GlaxoSmithKline | 100 | 2015-04-14 | 2024-03-12 |
| Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Doxorubicin, Doxorubicin Hydrochloride, Ifosfamide - Alveolar Soft Part Sarcoma, Angiomatoid Fibrous Histiocytoma | Phase 2 / Phase 3 | Completed | National Cancer Institute (NCI) | 140 | 2014-08-12 | 2026-06-17 |
| A Study to Investigate Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis Mepolizumab, Placebo - Churg-Strauss Syndrome | Phase 3 | Completed | GlaxoSmithKline | 136 | 2014-02-05 | 2018-01-31 |
| Association Corticosteroid/Azathioprine in Microscopic Polyangiitis/ Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome) corticosteroid and azathioprine, corticosteroid and placebo - MPA, PAN or EGPA With FFS=0 | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 114 | 2008-05-01 | 2025-09-12 |
Churg-Strauss Syndrome (6) · Chondrosarcoma, Extraskeletal Myxoid (1) · Chondrosarcoma, Mesenchymal (1) · Dermatofibrosarcoma (1) · Fibrosarcoma (1) · Fibrosis (1) · Granuloma, Plasma Cell (1) · Histiocytoma, Angiomatoid Fibrous (1) · Histiocytoma, Malignant Fibrous (1) · Inflammation (1) · Leiomyosarcoma (1) · Liposarcoma (1) · Lung Diseases, Interstitial (1) · Lymphoproliferative Disorders (1)
Hemic and Lymphatic Diseases (7) · Immune System Diseases (7) · Lymphatic Diseases (7) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (6) · Autoimmune Diseases (6) · Cardiovascular Diseases (6) · Lymphoproliferative Disorders (6) · Skin Diseases (6) · Skin Diseases, Vascular (6) · Skin and Connective Tissue Diseases (6) · Vascular Diseases (6) · Systemic Vasculitis (5) · Vasculitis (5) · Nervous System Diseases (2)
Azathioprine (3) · mepolizumab (3) · Cyclophosphamide (2) · Rituximab (2) · Adrenal Cortex Hormones (1) · Doxorubicin (1) · Ifosfamide (1) · Prednisolone (1) · Radiation (1) · Radiotherapy (1) · Sodium Chloride (1) · pazopanib (1)
Assistance Publique - Hôpitaux de Paris (4) · GlaxoSmithKline (2) · National Cancer Institute (NCI) (1) · aTyr Pharma, Inc. (1)
France (7) · United States (4) · Canada (3) · Germany (3) · Japan (3) · United Kingdom (3) · Belgium (2) · Italy (2) · Spain (2) · Brazil (1) · Netherlands (1) · Puerto Rico (1)
Aaron R Weiss (1) · Benjamin Terrier (1) · Lisa Carey (1) · Loic Guillevin, MD, PhD (1)
PMID 28514601, PMID 28678392, PMID 31056661, PMID 32702309, PMID 32827353, PMID 34515544, PMID 37523624, PMID 37902990, PMID 40008472, PMID 40720835
2016 (2), 2014 (1), U10CA098543 (1), U10CA180830 (1), U10CA180886 (1)