11 completed, 2 unknown, 1 recruiting. 14 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 14 | Completed 11, Unknown 2, Recruiting 1 |
Follow Graft Rejection: new trials by email Literature Review of Graft Rejection trials Research Report on Graft Rejection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Compare the Outcome of Receiving Continued Immunosuppression Versus Stopping Immunosuppression at 6 Months to Safely Prevent Human Leukocyte Antigen (HLA) Sensitization in Patients With Late Renal Graft Failure Continue low dose calcineurin inhibitor (CNI), Calcineurin inhibitor withdrawal at 6 months - Renal Failure , Chronic, Graft Failure | Phase 4 | Recruiting | Hospital Universitari Vall d'Hebron Research Institute | 202 | 2024-01-22 | 2024-11-06 |
| Montelukast in Bronchiolitis Obliterans Syndrome Montelukast - Bronchiolitis Obliterans, Lung Transplantation | Phase 4 | Completed | Universitaire Ziekenhuizen KU Leuven | 30 | 2010-10-01 | 2015-03-05 |
| Study Evaluating A Planned Transition From Tacrolimus To Sirolimus In Kidney Transplant Recipients Tacrolimus, Sirolimus - Graft Rejection, Kidney Transplant | Phase 4 | Completed | Pfizer | 254 | 2009-06-01 | 2014-09-18 |
| Standard Versus Prolonged-release Tacrolimus Monotherapy After Alemtuzumab Induction in Kidney Transplantation Tacrolimus (Kidney transplant maintenance immunosuppression), Kidney transplant maintenance immunosuppression - End-stage Renal Failure, Graft Rejection | Phase 4 | Completed | Imperial College Healthcare NHS Trust | 102 | 2008-12-01 | 2021-08-27 |
| Thymoglobulin in Calcineurin Inhibitor and Steroid Minimization Protocol Thymoglobulin - Diabetes, Graft Rejection | Phase 4 | Unknown | University Health Network, Toronto | 30 | 2008-02-01 | 2008-06-27 |
| Study of Rituximab to Treat Chronic Renal Transplant Rejection Rituximab, Control arm - Kidney Transplantation, Graft Rejection | Phase 4 | Completed | King's College London | 62 | 2007-01-01 | 2020-03-05 |
| Study Of The Safety And Efficacy Of Conversion From A CNI To Sirolimus In Renally-Impaired Heart Transplant Recipients cyclosporine or tacrolimus, sirolimus - Graft Rejection, Kidney Failure | Phase 4 | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | 121 | 2006-09-01 | 2011-05-30 |
| Azithromycin in Bronchiolitis Obliterans Syndrome Azithromycin, Placebo - Bronchiolitis Obliterans Syndrome, Graft Rejection | Phase 4 | Completed | KU Leuven | 83 | 2005-09-01 | 2011-10-03 |
| Study of Alemtuzumab Versus Anti-thymocyte Globulin to Help Prevent Rejection in Kidney and Pancreas Transplantation Alemtuzumab, Anti-Thymocyte Globulin - Graft Rejection | Phase 4 | Completed | Wake Forest University Health Sciences | 222 | 2005-02-01 | 2018-09-06 |
| Study Comparing Two Sirolimus Regimens vs. Tacrolimus and Mycophenolate Mofetil Regimen in Kidney Transplant Recipients Sirolimus - Graft Rejection, Kidney Failure | Phase 4 | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | 420 | 2004-03-01 | 2007-12-27 |
| Study Evaluating Two Different Sirolimus-based Immunosuppressive Regimens in Elderly Kidney Transplant Recipients Sirolimus - Kidney Failure, Graft Rejection | Phase 4 | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | 66 | 2002-10-01 | 2012-01-31 |
| A Study to Compare the Conversion to Prograf® (Tacrolimus) to the Continuation of Cyclosporine in Patients at Risk for Chronic Renal Allograft Failure tacrolimus - Graft Rejection, Kidney Transplantation | Phase 4 | Completed | Astellas Pharma Inc | 450 | 1999-02-01 | 2007-08-02 |
| Study Comparing Two Immunosuppressive Regimens in De Novo Renal Allograft Recipients tacrolimus, mycophenolate mofetil, methylprednisolone - Graft Rejection, Kidney Failure | Phase 4 | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | 160 | 2006-05-19 | |
| Renal Function Optimization With Mycophenolate Mofetil (MMF) Immunosuppressor Regimes (ALHAMBRA) Tacrolimus, Rapamycin - Kidney Diseases, Graft Rejection | Phase 4 | Unknown | Sociedad Andaluza de Trasplantes de Organos y Tejidos | 94 | 2007-05-15 |
Renal Insufficiency (5) · Bronchiolitis Obliterans Syndrome (2) · Kidney Failure, Chronic (2) · Rejection, Psychology (2) · Bronchiolitis Obliterans (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 1 (1) · Diabetes Mellitus, Type 2 (1) · Kidney Diseases (1) · Renal Insufficiency, Chronic (1) · Respiratory Tract Infections (1)
Female Urogenital Diseases (8) · Female Urogenital Diseases and Pregnancy Complications (8) · Male Urogenital Diseases (8) · Urogenital Diseases (8) · Urologic Diseases (8) · Kidney Diseases (7) · Chronic Disease (3) · Disease Attributes (3) · Immune System Diseases (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Behavior (2) · Bronchial Diseases (2) · Bronchiolitis (2) · Bronchitis (2)
Sirolimus (6) · Tacrolimus (6) · Cyclosporine (2) · Mycophenolic Acid (2) · Alemtuzumab (1) · Antilymphocyte Serum (1) · Azithromycin (1) · Calcineurin Inhibitors (1) · Cyclosporins (1) · Methylprednisolone (1) · Methylprednisolone Hemisuccinate (1) · Prednisolone (1) · Prednisone (1) · Rituximab (1) · Steroids (1)
Wyeth is now a wholly owned subsidiary of Pfizer (4) · Astellas Pharma Inc (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · Imperial College Healthcare NHS Trust (1) · KU Leuven (1) · King's College London (1) · Pfizer (1) · Sociedad Andaluza de Trasplantes de Organos y Tejidos (1) · Universitaire Ziekenhuizen KU Leuven (1) · University Health Network, Toronto (1) · Wake Forest University Health Sciences (1)
Spain (4) · United States (4) · Australia (2) · Belgium (2) · Canada (2) · United Kingdom (2) · Argentina (1) · Austria (1) · Brazil (1) · Germany (1) · Italy (1) · New Zealand (1) · Switzerland (1)
Adam G McLean, MA DPhil (1) · Alan C Farney, MD, Ph.D. (1) · Anthony Dorling, PhD FRCP (1) · Edward Cole (1) · Geert M Verleden, MD, PhD (1) · Geert M Verleden, Prof. Dr. (1) · John Gill (1) · John Holman, MD (1) · Miguel A Gonzalez Molina, MD (1) · Ramesh Prasad (1)
PMID 20562124, PMID 22776430, PMID 23369458, PMID 26372728, PMID 32117242, PMID 39735417
2008 (1), 2023 (1)