7 recruiting, 6 not yet recruiting, 2 active not recruiting, 2 completed. 13 Not applicable, 2 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Recruiting 7, Not yet recruiting 5, Completed 1 |
| Phase 2 | 2 | Active not recruiting 1, Not yet recruiting 1 |
| Phase 3 | 1 | Completed 1 |
Follow Functional Constipation (FC): new trials by email Literature Review of Functional Constipation (FC) trials Research Report on Functional Constipation (FC)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of a New Non-invasive Device With the Invasive Gold-standard Investigation to Assess Function of the Large Bowel in Children Body Surface Colonic Mapping - Bowel Dysfunction, Dysmotility | Not applicable | Recruiting | Murdoch Childrens Research Institute | 50 | 2026-09-02 | 2026-11-12 |
| Evaluation of Fluoxetine for Refractory Constipation With Somatic Symptom Disorder Features Fluoxetine, Placebo - Refractory Constipation, Somatic Symptom Disorder (DSM-5) | Phase 2 | Not yet recruiting | Zhifeng Zhao, PhD | 194 | 2026-09-01 | 2026-09-02 |
| This is a Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study of the Efficacy and Safety of 2 Weight-based Treatment Groups of Plecanatide Versus Placebo in Children and Adolescent Participants 6 to Less Than 18 Years of Age With FC plecanatide, Placebo - Functional Constipation (FC) | Phase 2 | Active not recruiting | Bausch Health Americas, Inc. | 180 | 2026-08-18 | 2026-10-29 |
| Implementation of Physical Therapy Protocol for Functional Constipation Standard medical treatment, Maitland orthopedic manual therapy (MOMT), Russian current stimulation (ERS) - Functional Constipation (FC) | Not applicable | Not yet recruiting | Cairo University | 60 | 2026-08-01 | 2026-07-23 |
| Functional Constipation and Fall-Related Outcomes in Older Adults Functional Constipation (FC), Accidental Falls | Active not recruiting | Izmir Bakircay University | 208 | 2026-05-15 | 2026-06-05 | |
| Dose-Effect Response in Acupuncture for Functional Constipation Manual Acupuncture, Electroacupuncture - Functional Constipation (FC) | Not applicable | Recruiting | Tongji Hospital | 72 | 2026-05-11 | 2026-05-14 |
| Fiber Nutritional Supplement for Management of Constipation During Pregnancy fiber supplement (PHGG) with counselling for constipation management - Functional Constipation (FC) | Not applicable | Recruiting | Société des Produits Nestlé (SPN) | 31 | 2026-05-08 | 2026-09-25 |
| COMBINED EXERCISE AND MASSAGE PROGRAM IN CHILDREN WITH FUNCTIONAL CONSTIPATION Stretching, Strengthening, and Stabilization Exercises, Abdominal Massage (I Love You Technique), Standard Care and Education - Functional Constipation (FC) | Not applicable | Not yet recruiting | Zeynep Idil Sevimli | 40 | 2026-02-01 | 2026-01-13 |
| Transcranial Alternating Current Stimulation for Refractory Constipation With Somatic Symptom Disorder Transcranial Alternating Current Stimulation, Placebo - Functional Constipation (FC), Somatic Symptom Disorder (DSM-5) | Not applicable | Recruiting | Xijing Hospital of Digestive Diseases | 60 | 2025-08-20 | 2026-01-09 |
| The Beneficial Effect on the Bowel Function of a Food Supplement Based on Sea Buckthorn (Hippophae Rhamnoides L.) Extract in Subjects With Primary Functional Constipation Sea Buckthorn (Hippophae rhamnoides L.) botanical extract 500 mg., Sea buckthorn (Hippophae rhamnoides L.) 1500 mg., Placebo - Functional Constipation (FC) | Not applicable | Recruiting | ISTITUTO FARMOCHIMICO FITOTERAPICO: EPO SRL | 135 | 2025-07-24 | 2025-07-30 |
| GUTPROH: Probiotic-Herbal Formula for Self-Reported Constipation in Community Adults Placebo Intervention, Probiotic Intervention, Probiotic with Herbal Powder Intervention - Functional Constipation (FC) | Not applicable | Not yet recruiting | Beijing Hospital | 300 | 2025-07-10 | 2025-06-26 |
| Baliao Acupoint Stimulation toTreat Functional Constipation Acupuncture, Sham acupuncture - Functional Constipation (FC) | Not applicable | Not yet recruiting | Affiliated Hospital of Nanjing University of Chinese Medicine | 36 | 2025-06-20 | 2025-06-08 |
| Efficacy of Notrande Shuhuajun Probiotic Supplement on Lmproving Constipation in Preschool Children Nuotelande Shuhuajun Study Product - Functional Constipation (FC) | Not applicable | Completed | Shandong Sibote Biotechnology Co., Ltd. | 102 | 2025-05-30 | 2025-12-19 |
| Acupuncture for Children with Functional Constipation Acupuncture treatment - Functional Constipation (FC) | Not applicable | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 18 | 2025-02-20 | 2025-02-20 |
| Effect of Lactobacillus DSM17938+ on Functional Constipation and Intestinal Flora in Pregnant Women Intervention with probiotic bacteria, Lactulose oral solution treatment - Functional Constipation (FC) | Not applicable | Recruiting | Peking Union Medical College Hospital | 40 | 2025-01-09 | 2025-01-30 |
| Effects of Probiotics on Symptoms of Constipation in Adults With Functional Constipation Placebo, Probiotics (ABKefir) - Functional Constipation (FC) | Not applicable | Recruiting | Chung Shan Medical University | 165 | 2024-12-27 | 2026-01-02 |
| A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation Placebo for Linaclotide, Linaclotide - Functional Constipation (FC), Chronic Idiopathic Constipation (CIC) | Phase 3 | Completed | AbbVie | 123 | 2022-12-29 | 2026-05-14 |
Constipation (6) · Anorectal Malformations (1) · Hirschsprung Disease (1) · Intestinal Diseases (1) · Motor Activity (1)
Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (6) · Signs and Symptoms, Digestive (6) · Behavior (1) · Colonic Diseases (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Digestive System Abnormalities (1) · Digestive System Diseases (1) · Gastrointestinal Diseases (1) · Megacolon (1)
Acupuncture Therapy (2) · Probiotics (2) · Breathing Exercises (1) · Educational Status (1) · Electroacupuncture (1) · Fluoxetine (1) · Methods (1) · Standard of Care (1) · Transcranial Direct Current Stimulation (1) · linaclotide (1) · plecanatide (1)
AbbVie (1) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Affiliated Hospital of Nanjing University of Chinese Medicine (1) · Bausch Health Americas, Inc. (1) · Beijing Hospital (1) · Cairo University (1) · Chung Shan Medical University (1) · ISTITUTO FARMOCHIMICO FITOTERAPICO: EPO SRL (1) · Izmir Bakircay University (1) · Murdoch Childrens Research Institute (1) · Peking Union Medical College Hospital (1) · Shandong Sibote Biotechnology Co., Ltd. (1) · Société des Produits Nestlé (SPN) (1) · Tongji Hospital (1) · Xijing Hospital of Digestive Diseases (1)
China (4) · Turkey (Türkiye) (2) · United States (2) · Australia (1) · Brazil (1) · Bulgaria (1) · Italy (1) · Netherlands (1) · Taiwan (1) · United Kingdom (1)
Charlie Zhang, MD (1) · Hsin-Chi Pan, MS student (1) · Liang Sun, Ph.D (1) · Qingchuan Zhao, Prof. (1) · Sebastian K King, MBBS, PhD, FRACS (1) · Shabei Xu (1)
PMID 25642064, PMID 27821950, PMID 31372099, PMID 31945360, PMID 32718574, PMID 33586685, PMID 33737952, PMID 34090581, PMID 34603471, PMID 35554601, PMID 36820766, PMID 38848393, PMID 39707279, PMID 41218934