25 completed, 2 unknown, 1 active not recruiting, 1 terminated. 7 Phase 1, 6 Not applicable, 6 Phase 2, 4 Phase 3, 4 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 4, Terminated 1, Unknown 1, Withdrawn 1 |
| Not applicable | 6 | Completed 6 |
| Phase 2 | 6 | Completed 6 |
| Phase 3 | 4 | Completed 4 |
| Phase 4 | 4 | Completed 3, Unknown 1 |
Follow Falciparum Malaria: new trials by email Literature Review of Falciparum Malaria trials Research Report on Falciparum Malaria
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Evaluation of Long-term Sequelae in Patients With Severe Plasmodium Falciparum Malaria Questionnaire - Falciparum Malaria | Not applicable | Completed | Assistance Publique Hopitaux De Marseille | 56 | 2025-06-17 | 2025-12-05 |
| A Study to Determine Safety, Tolerability, and Pharmacokinetics of Different Orally Administered Regimens of the Combination ZY19489-Ferroquine in Adult Asymptomatic Plasmodium Falciparum Carriers ZY19489 + Ferroquine (FQ), Placebo - Uncomplicated Malaria, Asymptomatic Condition | Phase 1 | Unknown | Zydus Lifesciences Limited | 36 | 2024-08-30 | 2024-10-01 |
| Malaria Molecular Surveillance in Mozambique (Phase 2) LDH-based malaria rapid diagnostic test, Malaria rapid diagnostic test - Malaria, Falciparum Malaria | Active not recruiting | Centro de Investigacao em Saude de Manhica | 18750 | 2024-04-01 | 2026-10-21 | |
| Nitrite Infusion in Children With Malaria Sodium Nitrite - Falciparum Malaria | Phase 1 | Withdrawn | Duke University | 2021-06-01 | 2021-03-16 | |
| Efficacy and Safety of Artesunate-amodiaquine and Artemether-lumefantrine for the Treatment of Malaria in Cameroon Artesunate-amodiaquine drug combination, Artemether-lumefantrine drug combination - Falciparum Malaria | Phase 4 | Unknown | University of Yaounde 1 | 184 | 2021-04-05 | 2021-04-02 |
| Biological Mechanisms in Afebrile P. Falciparum Malaria No intervention - Falciparum Malaria | Completed | Alfredo Mayor | 475 | 2020-03-01 | 2023-09-01 | |
| Reducing the Risk of P. Vivax After Falciparum Infections in Co-endemic Areas primaquine - Malaria, Vivax Malaria | Phase 4 | Completed | Menzies School of Health Research | 500 | 2019-08-18 | 2023-11-21 |
| TES of Artemether-lumefantrine for Pf and Chloroquine for Pv in the Philippines From 2013-2014 Arthemeter-lumefantrine, Chloroquine, Primaquine - Malaria, Falciparum Malaria | Completed | Research Institute for Tropical Medicine, Philippines | 159 | 2013-05-01 | 2023-07-21 | |
| Evaluation of the Gametocytocidal Efficacy and Safety of Primaquine in Uncomplicated Falciparum Malaria in Uganda Primaquine - Falciparum Malaria | Phase 3 | Completed | London School of Hygiene and Tropical Medicine | 468 | 2011-12-01 | 2013-06-12 |
| Azithromycin Combination Therapy for the Treatment of Severe Malaria Artesunate, Azithromycin + Artesunate - Falciparum Malaria | Phase 2 | Completed | Medical University of Vienna | 75 | 2011-07-01 | 2013-08-23 |
| Tracking Resistance to Artemisinin (TRAC) Artesunate 2, Artesunate 4 - Falciparum Malaria | Phase 4 | Completed | University of Oxford | 1700 | 2011-05-01 | 2015-06-01 |
| Effectiveness of the Association Artesunate and Mefloquine in the Treatment of Malaria by Plasmodium Falciparum artesunate & mefloquine combination - Falciparum Malaria | Phase 2 / Phase 3 | Completed | Oswaldo Cruz Foundation | 163 | 2010-11-01 | 2015-05-19 |
| Artesunate+Sulfadoxine-Pyrimethamine for the Treatment of Uncomplicated Falciparum Malaria artesunate plus sulfadoxine-pyrimethamine (AS+SP) - Falciparum Malaria | Completed | University of Oxford | 100 | 2010-03-01 | 2012-07-12 | |
| Efficacy of ArTiMist™ in Children Quinine, Artemether - Falciparum Malaria | Phase 2 | Completed | Proto Pharma Ltd | 31 | 2009-12-01 | 2011-01-27 |
| Bioequivalence Study Comparing Artesunate Tablet To Arsuamoon® Tablets (Guilin-China) In Healthy Subjects Artesunate (Test), Artesunate (Comparator) - Falciparum Malaria | Phase 1 | Completed | Pfizer | 40 | 2009-06-01 | 2010-06-25 |
| A Bioequivalence Study Comparing Amodiaquine Tablet (Pfizer) To Amodiaquine Tablets (Arsuamoon-Guilin China) In Healthy Subjects Amodiaquine (Test), Amodiaquine (Comparator) - Falciparum Malaria | Phase 1 | Completed | Pfizer | 38 | 2009-06-01 | 2010-04-21 |
| A Bioequivalence Study Comparing Camoquin® Suspension (Pfizer) To Flavoquine® Tablets (Sanofi Aventis) In Healthy Subjects Flavoquine®, Camoquin® Suspension - Falciparum Malaria | Phase 4 | Completed | Pfizer | 38 | 2009-05-01 | 2010-04-21 |
| Artemisinin Resistance in Cambodia II Artesunate - Falciparum Malaria | Not applicable | Completed | Armed Forces Research Institute of Medical Sciences, Thailand | 143 | 2008-07-01 | 2011-01-25 |
| Phase Ib Trial of Two Virosome Formulated Malaria Vaccine Components (PEV 301, PEV 302) in Tanzania PEV 301& 302 in virosomes, Inflexal V (active comparator) - Falciparum Malaria | Phase 1 | Completed | Swiss Tropical & Public Health Institute | 50 | 2008-01-01 | 2013-03-15 |
| Clinical Investigation of In-vivo Susceptibility of P.Falciparum to Artesunate in Western Cambodia Artesunate, Artesunate + Mefloquine - Falciparum Malaria | Not applicable | Completed | University of Oxford | 40 | 2007-06-01 | 2018-05-04 |
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Malaria, Falciparum (30) · Malaria (14) · Malaria, Vivax (5) · Asymptomatic Diseases (1) · Communicable Diseases (1) · Parasitic Diseases (1) · Protozoan Infections (1)
Infections (30) · Mosquito-Borne Diseases (30) · Vector Borne Diseases (30) · Parasitic Diseases (29) · Protozoan Infections (29) · Malaria (16) · Disease Attributes (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2)
Artesunate (9) · Chloroquine (4) · Primaquine (4) · Amodiaquine (3) · Artemether, Lumefantrine Drug Combination (2) · Azithromycin (2) · Mefloquine (2) · fanasil, pyrimethamine drug combination (2) · Artemether (1) · Inflexal V (1) · Injections (1) · Malaria Vaccines (1) · Quinine (1) · Rosiglitazone (1) · Sodium Nitrite (1)
Pfizer (4) · Menzies School of Health Research (3) · University of Oxford (3) · London School of Hygiene and Tropical Medicine (2) · Swiss Tropical & Public Health Institute (2) · Alfredo Mayor (1) · Armed Forces Research Institute of Medical Sciences, Thailand (1) · Assistance Publique Hopitaux De Marseille (1) · Centro de Investigacao em Saude de Manhica (1) · Duke University (1) · Mahidol University (1) · Medical University of Vienna (1) · Medicines for Malaria Venture (1) · Oswaldo Cruz Foundation (1) · Proto Pharma Ltd (1)
Cambodia (4) · India (4) · Thailand (4) · Bangladesh (3) · Indonesia (3) · Tanzania (3) · Kenya (2) · Mozambique (2) · Singapore (2) · Vietnam (2) · Afghanistan (1) · Brazil (1) · Burkina Faso (1) · Burma (1) · Colombia (1)
Blaise Genton, MD PhD (2) · Alice C Eziefula, MBBS MCRP MRCPath (1) · Badria B El-Sayed, PhD (1) · Bryan Smith, MD (1) · Colin Sutherland, PhD. (1) · Daryl Bendel, MBChB MBA Dip Pharm Med MFPM (1) · Delia Bethell, BM BCh (1) · Dr. Deven Parmar, MD,FCP (1) · Duong Socheat, MD (1) · Emiliana Tjitra (1) · Emiliana Tjitre, PhD (1)
PMID 17336652, PMID 17925866, PMID 18060072, PMID 19641202, PMID 19641203, PMID 19673614, PMID 20350192, PMID 20658481, PMID 21070142, PMID 21603629, PMID 21799810, PMID 22475593, PMID 23433102, PMID 24239324, PMID 25075834, PMID 26303805, PMID 26666916, PMID 26917051, PMID 27068396, PMID 27197604, PMID 28081133, PMID 35585641, PMID 37979594, PMID 39581722, PMID 42439801
R01HL130763 (1)