392 completed, 176 unknown, 150 recruiting, 60 not yet recruiting. 300 Not applicable, 110 Phase 2, 63 Phase 3, 49 Phase 4, 41 Phase 1.
Follow Endometriosis: new trials by email Literature Review of Endometriosis trials Research Report on Endometriosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial. Esketamine, Placebo - Endometriosis | Phase 4 | Not yet recruiting | Region Skane | 1000 | 2028-01-01 | 2026-10-19 |
| Appendectomy as an Adjunct Procedure in Endometriosis Surgery Appendectomy, Standard of Care (SOC) - Endometriosis | Not applicable | Not yet recruiting | Mount Sinai Hospital, Canada | 240 | 2027-04-01 | 2026-09-16 |
| The Effect of Preoperative Pelvic Floor Physical Therapy (Prehabilitation) on Postoperative Pain Following Endometriosis Surgery: A Randomized Controlled Trial Structured pre-operative pelvic floor physiotherapy program (prehabilitation) - Endometriosis, Chronic Pelvic Pain | Not applicable | Not yet recruiting | University of Alberta | 150 | 2027-03-01 | 2026-09-18 |
| Impact of the Antihistamine Desloratadine on the Quality of Life and Dysmenorrhea in Patients With Endometriosis Desloratadine, Placebo - Endometriosis, Endometriosis (Diagnosis) | Phase 2 | Not yet recruiting | Medical University of Vienna | 60 | 2027-02-01 | 2026-09-18 |
| Exposure to Persistent Organic Pollutants and Severity of Endometriosis in the ComPaRe-Endometriosis Cohort Blood samples - Endometriosis | Not yet recruiting | Institut National de la Santé Et de la Recherche Médicale, France | 650 | 2026-12-01 | 2026-09-16 | |
| Laparoscopic Sclerotherapy for the Management of Ovarian Endometriomas Laparoscopic sclerotherapy - Endometriosis, Endometrioma | Not yet recruiting | Northwestern University | 20 | 2026-10-16 | 2026-08-24 | |
| The Impact of Yoga on Endometriosis-Related Pain Yoga - Endometriosis | Not applicable | Recruiting | Milton S. Hershey Medical Center | 30 | 2026-10-15 | 2026-10-06 |
| Study on the Ultrasound and Biological Characteristics of Atypical Endometriosis. Retrospective case-control analysis, prospective case-control group - Endometriosis | Recruiting | Casa di Cura Dott. Pederzoli | 200 | 2026-10-01 | 2026-09-11 | |
| Brain and Blood Vessel Health Following Endometriosis Treatment in People With Endometriosis Investigate how norethindrone acetate, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health, Investigate how Orlissa, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health, Investigate how Oriahnn, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health - Endometriosis, Endometriosis and Dysmenorrhea | Phase 4 | Not yet recruiting | Colorado State University | 45 | 2026-10-01 | 2026-09-02 |
| Stellate Ganglion Block and Dexmedetomidine for Postoperative Sleep in Women Undergoing Laparoscopic Gynecologic Surgery DEX 0.2 μg/kg/h., SGB, 0.9% Sodium Chloride (Placebo) - Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus | Not applicable | Recruiting | Catherin Zhang | 100 | 2026-10-01 | 2026-10-06 |
| Perioperative Yoga Therapy and Endometriosis Surgery Standard surgical management for endometriosis, Structured perioperative yogatherapy programme plus standard surgical management - Endometriosis, Chronic Pain | Not applicable | Not yet recruiting | University Hospital, Lille | 188 | 2026-10-01 | 2026-10-02 |
| Endodontic Microsurgery Platelet rich fibrin - Apical Periodontitis | Phase 4 | Not yet recruiting | Mark Schachman | 20 | 2026-10-01 | 2026-07-29 |
| Protective Factors for Well-being in Endometriosis Patients EMPOWER, Control - Endometriosis | Not applicable | Not yet recruiting | Maximiliane Uhlich | 200 | 2026-10-01 | 2026-10-02 |
| Vaginal Sildenafil for Primary Dysmenorrhea Sildenafil citrate vaginal suppository - Dysmenorrhea, Menstrual Pain | Phase 1 | Not yet recruiting | Kevin Hellman | 10 | 2026-10-01 | 2026-09-25 |
| Trial Evaluating Nutritional Fiber in Digestive Symptoms of Endometriosis Fiber, Placebo - Endometriosis, Microbiome Dysbiosis | Not applicable | Recruiting | LOAM Science | 140 | 2026-10-01 | 2026-10-22 |
| Rimegepant For Endometriosis Pain Rimegepant 75 MG, Placebo - Endometriosis, Endometriosis-related Pain | Phase 2 | Not yet recruiting | Mayo Clinic | 132 | 2026-09-30 | 2026-08-31 |
| Prospective Trial of [18F]AlF-FAPI-74 for PET Imaging of Fibroblast Activation Protein in Patients With Endometriosis [18F]AlF-FAPI-74 PET/CT - Endometriosis, Deep Infiltrating Endometriosis | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 64 | 2026-09-30 | 2026-10-19 |
| Effects of Physiotherapy on Ultrasound and Clinical Parameters in Women With Dysmenorrhea Abdominal manual mobilization, Sham manual contact - Dysmenorrhea, Endometriosis | Not applicable | Not yet recruiting | Vrije Universiteit Brussel | 80 | 2026-09-01 | 2026-06-12 |
| Artificial Intelligence Into Ultrasound Diagnostics in Reproductive Medicine Endometriosis, Adenomyosis of Uterus | Recruiting | Semmelweis University | 1600 | 2026-09-01 | 2026-09-18 | |
| Assessing the Mechanisms and Impact of a Novel Cannabinoid Product for Gynecologic Pain Custom-formulated, high-CBD study product, Placebo - Endometriosis, Adenomyosis | Phase 1 / Phase 2 | Recruiting | Staci Gruber, Ph.D. | 60 | 2026-09-01 | 2026-07-27 |
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Pelvic Pain (91) · Infertility (57) · Dysmenorrhea (56) · Pain (53) · Adenomyosis (41) · Leiomyoma (35) · Dyspareunia (31) · Chronic Pain (24) · Disease (23) · Infertility, Female (18) · Metrorrhagia (11) · Ovarian Cysts (11) · Ovarian Neoplasms (11) · Depression (10)
Female Urogenital Diseases and Pregnancy Complications (885) · Genital Diseases (885) · Urogenital Diseases (885) · Female Urogenital Diseases (884) · Genital Diseases, Female (880) · Pathological Conditions, Signs and Symptoms (261) · Signs and Symptoms (208) · Neurologic Manifestations (197) · Pain (140) · Pathologic Processes (137) · Neoplasms (72) · Menstruation Disturbances (63) · Uterine Diseases (59) · Neoplasms by Histologic Type (46) · Male Urogenital Diseases (44)
dienogest (28) · elagolix (22) · Leuprolide (21) · Laparoscopy (17) · Blood Specimen Collection (13) · Surveys and Questionnaires (13) · Norethindrone Acetate (12) · Gonadotropin-Releasing Hormone (11) · relugolix (11) · Surgical Procedures, Operative (10) · Triptorelin Pamoate (10) · linzagolix (10) · Exercise (7) · Estradiol (6) · Ethanol (6)
Bayer (26) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (20) · AbbVie (14) · Assistance Publique - Hôpitaux de Paris (12) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (12) · Kanuni Sultan Suleyman Training and Research Hospital (11) · University of Cagliari (10) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (9) · Hospices Civils de Lyon (9) · Kissei Pharmaceutical Co., Ltd. (9) · Boston Children's Hospital (8) · Universitaire Ziekenhuizen KU Leuven (8) · University Hospital, Lille (8) · University of Aarhus (8) · Milton S. Hershey Medical Center (7)
United States (165) · France (123) · Italy (98) · Turkey (Türkiye) (47) · China (45) · Spain (41) · Germany (36) · Belgium (34) · Canada (34) · Egypt (28) · Poland (28) · United Kingdom (24) · Czechia (20) · Switzerland (19) · Brazil (17)
Diego Raimondo, MD (6) · Thomas D'Hooghe, MD, PhD (5) · Christel LC Meuleman, MD (4) · Fulvio Zullo (4) · Amparo Garcia-Tejedor, MDPhD (3) · Giorgia Gaia (3) · Gurkan Uncu, Prof. (3) · Heping Zhang, PhD (3) · Jehn-Hsiahn Yang, M.D. (3)
PMID 29476499, PMID 32621325, PMID 32945631, PMID 33963686, PMID 34878624, PMID 28525302, PMID 31069056, PMID 31654294, PMID 41065045, PMID 25392649, PMID 27741200, PMID 29935810, PMID 30299482, PMID 30724096, PMID 30992150, PMID 31227284, PMID 32769633, PMID 33066973, PMID 33095458, PMID 33564263, PMID 33650259, PMID 34134684, PMID 34826668, PMID 35717987, PMID 37283994, PMID 37479520, PMID 37982388, PMID 10645861, PMID 11727863, PMID 11748987, PMID 11756364, PMID 11869624, PMID 11875733, PMID 12113430, PMID 12372443, PMID 12606247, PMID 12742182, PMID 12800205, PMID 14622679, PMID 15533368, PMID 15541453, PMID 15551359, PMID 16600231, PMID 16968582, PMID 17077107, PMID 17094980, PMID 17218224, PMID 17272567, PMID 17462175, PMID 17999304
2017 (5), 2018 (4), 2019 (4), 2025 (4), 2004 (2), 2014 (2), K23HD043952 (2), 2009 (1), 2023 (1), K23HD099283 (1), P01HD106485 (1), R01DK100368 (1), R01HD096147 (1), R01HD096331 (1), R01HD100336 (1)