6 completed, 2 recruiting, 1 not yet recruiting. 9 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 6, Recruiting 2, Not yet recruiting 1 |
Follow Drug-Drug Interaction (DDI): new trials by email Literature Review of Drug-Drug Interaction (DDI) trials Research Report on Drug-Drug Interaction (DDI)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Drug-Drug Interaction Study Between NTQ5082 Capsules and Midazolam Oral Solutio NTQ5082, Midazolam - Healthy Volunteers, Drug-Drug Interaction (DDI) | Phase 1 | Not yet recruiting | The Third Xiangya Hospital of Central South University | 18 | 2026-07-30 | 2026-08-04 |
| Safety and PK of Ceftibuten-ledaborbactam Etzadroxil Fixed-dose Combination Ledaborbactam etzadroxil, Ceftibuten, Ceftibuten-ledaborbactam etzadroxil - Healthy Volunteer, Pharmacokinetics | Phase 1 | Recruiting | Basilea Pharmaceutica | 96 | 2025-01-07 | 2026-07-09 |
| Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors Zanzalintinib, Nivolumab, Ipilimumab - Renal Cell Carcinoma (RCC), Metastatic Castration-Resistant Prostate Cancer (mCRPC) | Phase 1 | Recruiting | Exelixis | 1394 | 2021-12-14 | 2026-10-01 |
| Study to Evaluate the Effect of Solifenacin and Mirabegron on the Tamsulosin Hydrochloride (HCl) Concentrations in Blood in Healthy Male Subjects Mirabegron, Solifenacin succinate, Tamsulosin HCl - Healthy Subjects, Pharmacokinetics | Phase 1 | Completed | Astellas Pharma Europe B.V. | 20 | 2014-05-01 | 2014-08-29 |
| Study to Evaluate the Effect of Solifenacin and Mirabegron on the Digoxin Concentrations in Blood in Healthy Subjects Mirabegron, Solifenacin, Digoxin - Healthy Subjects, Pharmacokinetics | Phase 1 | Completed | Astellas Pharma Europe B.V. | 26 | 2014-03-01 | 2014-07-11 |
| A Study to Evaluate How a Drug That Alters Liver Enzymes (Rifampin) Affects the Metabolism of Enzalutamide in Men enzalutamide, rifampin - Drug-Drug Interaction (DDI), Healthy Subjects | Phase 1 | Completed | Astellas Pharma Europe B.V. | 28 | 2013-07-01 | 2014-10-15 |
| A Study to Assess the Effects of Multiple Doses of Fidaxomicin on a Single Dose of Rosuvastatin in Healthy Male Subjects rosuvastatin, fidaxomicin - Drug-Drug Interaction (DDI), Intestinal Absorption | Phase 1 | Completed | Astellas Pharma Europe B.V. | 25 | 2013-02-01 | 2014-05-21 |
| A Study to Assess the Effect of Multiple Doses of Gemfribozil on a Single Dose of ASP3652, and to Assess the Effects of Multiple Doses of ASP3652 on a Single Dose of Repaglinide in the Body of Healthy Subjects ASP3652, Gemfibrozil, Repaglinide - Drug-Drug Interaction (DDI), Healthy Subjects | Phase 1 | Completed | Astellas Pharma Europe B.V. | 48 | 2012-04-01 | 2013-02-22 |
| A Study to Evaluate Whether Verapamil Has an Effect on the Uptake and Elimination of Solifenacin and Tamsulosin When Administered in a Combination Tablet EC905, verapamil - Drug-Drug Interaction (DDI), Healthy Subjects | Phase 1 | Completed | Astellas Pharma Europe B.V. | 36 | 2009-08-01 | 2014-05-30 |
Carcinoma, Hepatocellular (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Renal Cell (1) · Carcinoma, Transitional Cell (1) · Colorectal Neoplasms (1) · Squamous Cell Carcinoma of Head and Neck (1)
Adenocarcinoma (1) · Bronchial Neoplasms (1) · Carcinoma (1) · Carcinoma, Bronchogenic (1) · Carcinoma, Squamous Cell (1) · Colonic Diseases (1) · Digestive System Diseases (1) · Digestive System Neoplasms (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Gastrointestinal Diseases (1) · Gastrointestinal Neoplasms (1) · Head and Neck Neoplasms (1) · Intestinal Diseases (1) · Intestinal Neoplasms (1)
Solifenacin Succinate (3) · mirabegron (2) · ASP3652 (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Ceftibuten (1) · Digoxin (1) · Docetaxel (1) · Esomeprazole (1) · Fidaxomicin (1) · Gemfibrozil (1) · Ipilimumab (1) · Midazolam (1) · Nivolumab (1) · Prednisone (1) · Rifampin (1)
Astellas Pharma Europe B.V. (6) · Basilea Pharmaceutica (1) · Exelixis (1) · The Third Xiangya Hospital of Central South University (1)
Germany (5) · France (2) · United Kingdom (2) · United States (2) · Australia (1) · Austria (1) · Belgium (1) · Israel (1) · Italy (1) · New Zealand (1) · Poland (1) · Spain (1) · Switzerland (1)
Kamal Hamed, MD (1)
2009 (1), 2023 (1)