30 completed, 5 unknown, 4 recruiting. 27 Phase 1, 3 Not applicable, 3 Phase 4, 2 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 27 | Completed 25, Recruiting 1, Unknown 1 |
| Not applicable | 3 | Completed 1, Recruiting 1, Unknown 1 |
| Phase 4 | 3 | Completed 3 |
| Early Phase 1 | 2 | Completed 1, Recruiting 1 |
Follow Drug-drug Interaction: new trials by email Literature Review of Drug-drug Interaction trials Research Report on Drug-drug Interaction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Learn About How Safe BAY3389934 is and How it Affects Blood Clotting When Given Alone or With Aspirin in Healthy Participants Aspirin, BAY3389934 - Drug-drug Interaction | Phase 1 | Recruiting | Bayer | 16 | 2026-05-29 | 2026-10-20 |
| Pharmacokinetic Effect of Y-3 on Repaglinide，Warfarin and Omeprazole in Healthy Participants sequentially single use of repaglinide, warfarin and omeprazole or combined with Y-3 - Pharmacokinetic Profiles, Y-3 for Injection | Phase 1 | Completed | Neurodawn Pharmaceutical Co., Ltd. | 24 | 2025-05-18 | 2026-05-22 |
| Pharmacokinetic Study of Long-acting Antiretrovirals and Contraceptives in HIV Long-acting injectable cabotegravir (CAB-LA), No PrEP - HIV Infections, Contraception | Recruiting | University of Alabama at Birmingham | 105 | 2025-01-24 | 2026-10-14 | |
| Determining the Clinical Relevance of the Interaction Between Enzalutamide and the Opioid Morphine and the DOAC Edoxaban Blood sampling - Pharmacokinetic assessment - Drug-drug Interaction | Unknown | Radboud University Medical Center | 26 | 2024-07-01 | 2022-10-27 | |
| Drug-drug Interactions With Anti-tuberculous Drugs Anti Tuberculosis Drug - Drug-drug Interaction | Unknown | Cairo University | 400 | 2024-04-30 | 2024-08-22 | |
| Interaction of CYP2B6 Genotype and Efavirenz With Methadone and Tizanidine PK Methadone and Tizanidine, Efavirenz, Methadone and Tizanidine - Drug-Drug Interaction | Early Phase 1 | Recruiting | Indiana University | 60 | 2023-10-06 | 2026-08-20 |
| A DDI Study of JMKX000623 and Metformin Hydrochloride JMKX000623, Metformin - Healthy, Drug-Drug Interaction | Phase 1 | Completed | Jemincare | 24 | 2023-09-17 | 2024-04-25 |
| Pharmaco-proteomic Platform to Evaluate Drug Interactions in Liver Transplant Patients Multi-drug interaction - Drug-drug Interaction, Liver Transplantation | Unknown | Pontificia Universidad Catolica de Chile | 48 | 2023-06-01 | 2024-11-12 | |
| Drug-drug Interactions Between DWC202211 and DWC202212 in Healthy Subjects DWC202211 100mg, DWC202212 5mg, DWC202211 100mg + DWC202212 5mg - Drug-drug Interaction | Phase 1 | Unknown | Daewoong Pharmaceutical Co. LTD. | 24 | 2023-02-15 | 2023-04-04 |
| A Study of PBI-200 With Ritonavir or Cobicistat in Healthy Volunteers PBI-200 Tablet, Ritonavir Oral Tablet, Cobicistat Oral Tablet - Drug-drug Interaction | Phase 1 | Completed | Pyramid Biosciences | 21 | 2022-09-09 | 2023-01-20 |
| Perpetrator DDI Potential of Givinostat as Inhibitor and Inducer of CYP3A and P-gp Activity Givinostat 10 mg/mL, Midazolam 1mg/ml IV, Midazolam 2.5 mg oromucosal solution - Drug-Drug Interaction, Heathy Volunteer | Phase 1 | Completed | Italfarmaco | 26 | 2022-03-21 | 2025-01-06 |
| The Effect of Dicloxacillin on Oral Absorption of Drugs Dicloxacillin - Healthy Volunteers, Drug-drug Interaction | Phase 1 | Completed | University of Southern Denmark | 12 | 2022-02-07 | 2022-07-21 |
| Drug-Drug Interaction Study to Investigate Effects of Voclosporin on Pharmacokinetics of Simvastatin Simvastatin, Voclosporin - Drug-drug Interaction | Phase 1 | Completed | Aurinia Pharmaceuticals Inc. | 24 | 2022-01-24 | 2022-04-20 |
| Kuwa Free! - Live Free! Cabotegravir/ Rilpivirine, Etonogestrel (ETG) implant, Intramuscular depo-medroxyprogesterone acetate (IM DMPA) - HIV Infections, Contraception | Not applicable | Recruiting | University of Alabama at Birmingham | 700 | 2021-11-26 | 2026-04-13 |
| Evaluation of Pharmacokinetic Drug-drug Interactions Between Hormonal Contraceptives and Doravirine-containing ART Among Women Living With HIV in South Africa Etonogestrel (ETG) implant, Intramuscular depo-medroxyprogesterone acetate (IM DMPA), Sub-cutaneous medroxyprogesterone acetate (SC MPA) - HIV Infections, Contraception | Phase 4 | Completed | University of Alabama at Birmingham | 110 | 2021-11-17 | 2025-04-08 |
| Drug-Drug Interaction Study of HBI-3000 and Paroxetine in Healthy Adult Male and Female Subjects HBI-3000, Paroxetine - Drug-drug Interaction | Phase 1 | Completed | HUYABIO International, LLC. | 39 | 2021-02-21 | 2022-07-15 |
| Dihydroartemisinin-Piperaquine in the Context of Antiretroviral Therapy Dihydroartemisinin-piperaquine - Drug-Drug Interaction, HIV Infection | Phase 4 | Completed | University of California, San Francisco | 194 | 2020-11-23 | 2025-03-14 |
| Study to Investigate the Potential Drug-Drug Interaction Between ZSP1273 and Oseltamivir ZSP1273, Oseltamivir - Drug-drug Interaction | Phase 1 | Completed | Guangdong Raynovent Biotech Co., Ltd | 36 | 2020-11-19 | 2021-11-04 |
| Drug-Drug Interaction Study of Lorecivivint and Triamcinolone Acetonide in Healthy Volunteers Lorecivivint (LOR), Triamcinolone acetonide (TA) - Drug-Drug Interaction | Phase 1 | Completed | Biosplice Therapeutics, Inc. | 40 | 2020-10-13 | 2021-01-12 |
| Pharmacokinetic Interaction Between DWP14012 and DWC202005 in Healthy Volunteers DWC202005, alone, DWP14012 + DWC202005, DWP14012 + DWC202005, after multiple doses of DWP14012 - Drug-drug Interaction | Phase 1 | Completed | Daewoong Pharmaceutical Co. LTD. | 36 | 2020-09-06 | 2021-08-16 |
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HIV Infections (4) · Inhibition, Psychological (2) · Arthritis, Rheumatoid (1) · Autoimmune Diseases (1) · Drug-Related Side Effects and Adverse Reactions (1) · Malaria (1)
Immune System Diseases (6) · Blood-Borne Infections (4) · Communicable Diseases (4) · Genital Diseases (4) · Immunologic Deficiency Syndromes (4) · Infections (4) · Lentivirus Infections (4) · RNA Virus Infections (4) · Retroviridae Infections (4) · Sexually Transmitted Diseases (4) · Sexually Transmitted Diseases, Viral (4) · Urogenital Diseases (4) · Virus Diseases (4) · Behavior (2) · Arthritis (1)
Omeprazole (4) · Dabigatran (3) · Itraconazole (3) · Midazolam (3) · Rifampin (3) · Dipyrone (2) · Gemfibrozil (2) · Metformin (2) · Paroxetine (2) · efavirenz (2) · etonogestrel (2) · quizartinib (2) · tucatinib (2) · 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid (1) · Antitubercular Agents (1)
University of Alabama at Birmingham (3) · Daewoong Pharmaceutical Co. LTD. (2) · Daiichi Sankyo Co., Ltd. (2) · Seagen Inc. (2) · University Hospital, Basel, Switzerland (2) · University of California, San Francisco (2) · Astellas Pharma Europe B.V. (1) · AstraZeneca (1) · Aurinia Pharmaceuticals Inc. (1) · Bayer (1) · Biosplice Therapeutics, Inc. (1) · Boryung Pharmaceutical Co., Ltd (1) · Cairo University (1) · Genfit (1) · Guangdong Raynovent Biotech Co., Ltd (1)
United States (14) · China (4) · Australia (3) · France (3) · South Korea (2) · Switzerland (2) · Botswana (1) · Chile (1) · Denmark (1) · Egypt (1) · Kenya (1) · Netherlands (1) · Portugal (1) · South Africa (1) · Turkey (Türkiye) (1)
Rena Patel, MD, MPH, MPhil (2) · Adeodata Kekitiinwa (1) · Alex Vo, PhD (1) · Anna Wald, MD, MPH (1) · Carlos Prendes, MD (1) · Connie Davis, MD. (1) · Edith Apondi (1) · Edwin Were (1) · Eun-Young Kim (1) · Francesca Aweeka (1) · Jason Lickliter, MBBS PhD FRACP (1) · Jason Lickliter, MD (1) · Jennifer Deering, MSN, ARNP (1)
PMID 39368039, PMID 25929560, PMID 29746911, PMID 35931943, PMID 37124199, PMID 37645440, PMID 37902943, PMID 39992105, PMID 42081083, PMID 7758252
2018 (2), 2019 (2), R01AI155052 (2), P01GM032165 (1), R01HD068174 (1), R35GM145383 (1)