16 completed. 16 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 16 | Completed 16 |
| Phase 2 | 3 | Completed 3 |
Follow Disease Progression: new trials by email Literature Review of Disease Progression trials Research Report on Disease Progression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fractionated Gemtuzumab Ozogamicin Followed by Non-engraftment Donor Leukocyte Infusions for Relapsed/Refractory Acute Myeloid Leukemia Gemtuzumab Ozogamicin (GO), Donor Leukocytes - Acute Myeloid Leukemia | Phase 1 / Phase 2 | Completed | Brown University | 11 | 2019-12-31 | 2026-07-23 |
| Niraparib and Copanlisib in Treating Patients With Recurrent Endometrial, Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Copanlisib, Niraparib - Deleterious BRCA1 Gene Mutation, Deleterious BRCA2 Gene Mutation | Phase 1 | Completed | M.D. Anderson Cancer Center | 31 | 2019-04-29 | 2026-07-23 |
| FLYSYN in MRD Positive AML FLYSYN - Acute Myeloid Leukemia | Phase 1 / Phase 2 | Completed | Synimmune GmbH | 31 | 2017-02-07 | 2023-12-28 |
| A Study to Evaluate the Safety, Tolerability and Immunogenicity of EGFR(V)-EDV-Dox in Subjects With Recurrent GBM EGFR(V)-EDV-Dox - Glioblastoma, Astrocytoma, Grade IV | Phase 1 | Completed | Engeneic Pty Limited | 9 | 2016-10-25 | 2025-06-03 |
| A Study to Assess the Safety, Tolerability and Anti-tumour Activity of Ascending Doses of Selumetinib in Combination With MEDI4736 and Selumetinib in Combination With MEDI4736 and Tremelimumab in Patients With Advanced Solid Tumours Selumetinib, MEDI4736, Tremelimumab - Lung Cancer, Melanoma | Phase 1 | Completed | AstraZeneca | 58 | 2015-12-28 | 2019-11-18 |
| Phase 1b Study Evaluating ACY-1215 (Ricolinostat) in Combination With Pomalidomide and Dexamethasone in Relapsed or Relapsed-and-Refractory Multiple Myeloma ACY-1215 in combination with pomalidomide and dexamethasone - Multiple Myeloma | Phase 1 | Completed | Celgene | 16 | 2014-09-15 | 2019-11-21 |
| CART-19 for Multiple Myeloma CART-19 T cells - Multiple Myeloma | Phase 1 | Completed | University of Pennsylvania | 13 | 2014-05-01 | 2023-06-22 |
| TMI With HD Mel in ASCT for R/R Multiple Myeloma (BMT-03) Total Marrow Irradiation, Melphalan, Filgrastim (G-CSF) - Multiple Myeloma, Relapsed, Multiple Myeloma, Refractory to Standard Treatment | Phase 1 | Completed | University of Illinois at Chicago | 12 | 2014-01-14 | 2024-11-13 |
| Investigating Safety, Tolerability and Efficacy of AZD5363 in Prostate Cancer. Intermittent dosing of AZD5363 - Metastatic Castrate-Resistant Prostate Cancer (mCRPC),, Efficacy, | Phase 1 | Completed | AstraZeneca | 59 | 2012-11-01 | 2014-06-19 |
| Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies Melphalan, Fludarabine, Mycophenolate mofetil - Blood And Marrow Transplantation, Leukemia | Phase 1 | Completed | M.D. Anderson Cancer Center | 33 | 2012-07-13 | 2017-04-28 |
| Pazopanib in Combination With PCI-24781 in Patients With Metastatic Solid Tumors PZP115891, PCI-24781 - Metastatic Solid Tumors | Phase 1 | Completed | Pamela Munster | 90 | 2012-06-25 | 2025-03-21 |
| Autologous Redirected RNA Meso-CIR T Cells Autologous T cells - Malignant Pleural Mesothelioma | Phase 1 | Completed | University of Pennsylvania | 18 | 2011-05-01 | 2017-09-19 |
| Evaluation of a New Anti-cancer Immunotherapy After Chemotherapy in Adult Patients With Acute Myeloid Leukemia (AML) GSK Biologicals' recombinant WT1 Antigen-Specific Cancer Immunotherapeutic (ASCI) - Leukaemia, Myelocytic, Acute | Phase 1 | Completed | GlaxoSmithKline | 34 | 2008-10-01 | 2018-08-07 |
| ZD6474 to Treat Advanced Brain Cancer in Patients Steroids, ZD6474 - Recurrent High-Grade Gliomas, Progressive Low-Grade Gliomas | Phase 1 | Completed | National Cancer Institute (NCI) | 83 | 2005-12-29 | 2019-12-05 |
| Core Decompression With or Without Cement Packing for ONFH Core Decompression, PMMA augmentation - Osteonecrosis | Phase 1 / Phase 2 | Completed | University of Minnesota | 37 | 1997-01-01 | 2020-01-18 |
| A Phase I Study of Methotrexate for HIV Infection Lamivudine, Methotrexate, Zidovudine - HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 30 | 2021-10-29 |
Leukemia, Myeloid, Acute (4) · Recurrence (4) · Leukemia (3) · Multiple Myeloma (3) · Pathologic Complete Response (3) · Brain Neoplasms (2) · Neoplasms (2) · AIDS-Related Complex (1) · Acquired Immunodeficiency Syndrome (1) · Biliary Tract Neoplasms (1) · Breast Neoplasms (1) · Colorectal Neoplasms (1) · Disease (1) · Endometrial Neoplasms (1)
Disease Attributes (16) · Pathologic Processes (16) · Pathological Conditions, Signs and Symptoms (16) · Neoplasms (12) · Neoplasms by Histologic Type (12) · Hematologic Diseases (7) · Hemic and Lymphatic Diseases (7) · Neoplasms by Site (6) · Immune System Diseases (5) · Immunoproliferative Disorders (4) · Leukemia, Myeloid (4) · Lymphoproliferative Disorders (4) · Blood Protein Disorders (3) · Cardiovascular Diseases (3)
Melphalan (2) · AZD 6244 (1) · Antilymphocyte Serum (1) · Blood Specimen Collection (1) · Bone Marrow Transplantation (1) · Busulfan (1) · Clofarabine (1) · Dexamethasone (1) · Filgrastim (1) · Gemtuzumab (1) · Granulocyte Colony-Stimulating Factor (1) · Lamivudine (1) · Methotrexate (1) · Mycophenolic Acid (1) · Rituximab (1)
AstraZeneca (2) · M.D. Anderson Cancer Center (2) · University of Pennsylvania (2) · Brown University (1) · Celgene (1) · Engeneic Pty Limited (1) · GlaxoSmithKline (1) · National Cancer Institute (NCI) (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Pamela Munster (1) · Synimmune GmbH (1) · University of Illinois at Chicago (1) · University of Minnesota (1)
United States (14) · France (1) · Germany (1) · United Kingdom (1)
Andrew Haas, MD, PhD (1) · Damiano Rondelli, MD (1) · Edward Stadtmauer, MD (1) · Egorin M (1) · Elizabeth Shpall, MD (1) · Fox L (1) · Gary L Gallia, M.D., Ph.D (1) · Helmut Salih, Prof. Dr. (1) · Himanshu Brahmbhatt, Ph. D (1) · Jennifer MacDiarmid, Ph.D (1) · John Reagan, MD (1) · Pamela Munster, MD (1) · Paul Stockman, MBCHB, PHD (1)
PMID 24777247, PMID 25778529, PMID 26352815, PMID 29065747, PMID 29669947, PMID 32379297, PMID 37587502, PMID 39509670, PMID 41528970
P01CA148600 (1)