3 recruiting, 1 not yet recruiting, 1 no longer available, 1 terminated. 4 Phase 1, 3 Phase 2, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Recruiting 3, Terminated 1 |
| Phase 2 | 3 | Recruiting 2, Terminated 1 |
| Early Phase 1 | 1 | Not yet recruiting 1 |
Follow DIPG Brain Tumor: new trials by email Literature Review of DIPG Brain Tumor trials Research Report on DIPG Brain Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas Eflornithine (DFMO), AMXT 1501 Dicaprate - Atypical Teratoid/Rhabdoid Tumor, Embryonal Tumor With Multilayered Rosettes | Phase 1 / Phase 2 | Recruiting | Milton S. Hershey Medical Center | 265 | 2026-05-13 | 2026-09-03 |
| Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age SIACI of cetuximab and bevacizumab - Glioblastoma Multiforme, Anaplastic Astrocytoma | Phase 1 / Phase 2 | Recruiting | University of Miami | 20 | 2025-06-19 | 2025-12-08 |
| Clinical Study of Allogeneic Vγ9Vδ2 T Cells in the Treatment of Brain Malignant Glioma Vγ9Vδ2 T cell - GBM, DIPG Brain Tumor | Early Phase 1 | Not yet recruiting | Beijing Tiantan Hospital | 25 | 2024-04-30 | 2024-05-02 |
| Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG B7H3 specific CAR T cell with IL-7Ra signaling domain - DIPG Brain Tumor, Diffuse Intrinsic Pontine Glioma | Phase 1 | Recruiting | Chulalongkorn University | 9 | 2024-03-01 | 2025-03-30 |
| Oral AMXT 1501 Dicaprate in Combination With IV DFMO AMXT1501, DFMO - Cancer, Solid Tumor | Phase 1 / Phase 2 | Terminated | Aminex Therapeutics, Inc. | 15 | 2022-11-29 | 2024-12-24 |
| Single Patient Compassionate Use / Expanded Access L-S-Gboxin (Lyophilized Form of S-Gboxin) for the Treatment of Diffuse Midline Glioma S-Gboxin - DIPG Brain Tumor, Diffuse Brainstem Glioma | No longer available | Petrov, Andrey | 2024-07-16 |
Diffuse Intrinsic Pontine Glioma (6) · Glioma (2) · Astrocytoma (1) · Breast Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Colorectal Neoplasms (1) · Endometrial Neoplasms (1) · Esophageal Neoplasms (1) · Glioblastoma (1) · Head and Neck Neoplasms (1) · Medulloblastoma (1) · Melanoma (1) · Mesothelioma, Malignant (1) · Neoplasms (1) · Neuroblastoma (1)
Brain Diseases (6) · Brain Neoplasms (6) · Brain Stem Neoplasms (6) · Central Nervous System Diseases (6) · Central Nervous System Neoplasms (6) · Infratentorial Neoplasms (6) · Neoplasms by Histologic Type (6) · Neoplasms by Site (6) · Neoplasms, Germ Cell and Embryonal (6) · Neoplasms, Glandular and Epithelial (6) · Neoplasms, Nerve Tissue (6) · Neoplasms, Neuroepithelial (6) · Nervous System Diseases (6) · Nervous System Neoplasms (6) · Neuroectodermal Tumors (6)
Bevacizumab (1) · Cetuximab (1) · Eflornithine (1)
Aminex Therapeutics, Inc. (1) · Beijing Tiantan Hospital (1) · Chulalongkorn University (1) · Milton S. Hershey Medical Center (1) · Petrov, Andrey (1) · University of Miami (1)
United States (3) · Australia (1) · China (1) · Thailand (1)
Giselle Saulnier Sholler, MD (1) · Heather McCrea, MD (1) · Michael Armstrong, MD (1) · Piti Techavichit, MD (1) · Sue Lee, MD (1) · Tao Sun (1)