7 completed, 2 recruiting, 1 active not recruiting. 5 Phase 2, 4 Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Recruiting 1 |
| Phase 1 | 4 | Completed 2, Recruiting 2 |
| Not applicable | 1 | Completed 1 |
Follow Cutaneous Neurofibroma: new trials by email Literature Review of Cutaneous Neurofibroma trials Research Report on Cutaneous Neurofibroma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Feasibility and Tolerability of IMLYGIC for the Treatment of Cutaneous Neurofibromas in Adults With NF1 Imlygic - NF1, Neurofibromatosis | Phase 1 | Recruiting | Johns Hopkins University | 10 | 2026-02-01 | 2026-05-08 |
| Mirdametinib Monotherapy in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF). Mirdametinib - NF1, Cutaneous Neurofibroma | Phase 1 / Phase 2 | Recruiting | Johns Hopkins University | 24 | 2024-02-12 | 2026-04-13 |
| DPCP to Treat Cutaneous Neurofibromas Associated With NF1 DPCP - Cutaneous Neurofibroma | Phase 1 | Completed | Nicholas Gulati | 17 | 2022-09-14 | 2024-05-06 |
| HIFU Treatment of Cutaneous Neurofibromas in Neurofibromatosis Type 1: Safety and Efficacy TOOsonix System ONE-M - Cutaneous Neurofibroma | Not applicable | Completed | Joergen Serup | 20 | 2022-04-13 | 2024-10-16 |
| NFX-179 Topical Gel Treatment for Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF) NFX-179 gel, Vehicle gel - Cutaneous Neurofibroma, Neurofibromatosis 1 | Phase 2 | Completed | NFlection Therapeutics, Inc. | 199 | 2021-09-29 | 2026-02-17 |
| Natural History Study of Cutaneous Neurofibromas in People With NF1 Evaluation of the natural history of cutaneous neurofibromas - Neurofibromatosis Type 1, Neurofibromatosis 1 | Active not recruiting | Johns Hopkins University | 500 | 2021-06-28 | 2026-10-23 | |
| Tolerability of Device Based Therapies for Neurofibromatosis Type 1 Cutaneous Neurofibromas Kybella, 1064nm laser, 755nm Alexandrite Laser - Cutaneous Neurofibroma | Phase 1 | Completed | Massachusetts General Hospital | 34 | 2021-06-02 | 2025-02-21 |
| NFX-179 Topical Gel Treatment in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF) NFX-179 Gel, Vehicle Gel - Neurofibromatosis 1, Cutaneous Neurofibroma | Phase 2 | Completed | NFlection Therapeutics, Inc. | 48 | 2020-08-21 | 2022-08-09 |
| Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma Laboratory Biomarker Analysis, Selumetinib Sulfate - Cutaneous Neurofibroma, Neurofibromatosis Type 1 | Phase 2 | Completed | National Cancer Institute (NCI) | 11 | 2017-08-26 | 2023-12-06 |
| Use of Topical Liquid Diclofenac Following Laser Microporation of Cutaneous Neurofibromas in Patients With NF1 Diclofenac Sodium, Saline Solution - Neurofibromatosis 1, Cutaneous Neurofibroma | Phase 2 | Completed | Fundação Educacional Serra dos Órgãos | 7 | 2017-02-15 | 2017-10-26 |
Neurofibromatosis 1 (8) · Neurofibromatoses (3) · Neurofibroma (2) · Optic Nerve Glioma (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Genetic Diseases, Inborn (8) · Heredodegenerative Disorders, Nervous System (8) · Neoplasms (8) · Neoplasms by Histologic Type (8) · Neoplasms, Nerve Tissue (8) · Neoplastic Syndromes, Hereditary (8) · Nerve Sheath Neoplasms (8) · Nervous System Diseases (8) · Neurocutaneous Syndromes (8) · Neurodegenerative Diseases (8) · Neuromuscular Diseases (8) · Peripheral Nervous System Diseases (8) · Neurofibroma (6) · Neurofibromatoses (5)
Deoxycholic Acid (1) · Diclofenac (1) · Lasers (1) · Lasers, Solid-State (1) · Saline Solution (1) · diphenylcyclopropenone (1) · mirdametinib (1) · talimogene laherparepvec (1)
Johns Hopkins University (3) · NFlection Therapeutics, Inc. (2) · Fundação Educacional Serra dos Órgãos (1) · Joergen Serup (1) · Massachusetts General Hospital (1) · National Cancer Institute (NCI) (1) · Nicholas Gulati (1)
United States (8) · Brazil (1) · Denmark (1) · Sweden (1)
Carlos Romo, MD (2) · Bruce R Korf (1) · Carlos G Romo, MD (1) · Guy Webster, MD, PhD (1) · Nicholas Gulati, MD, PhD (1) · R. Rox Anderson, MD (1) · Rebecca Brown, MD, PhD (1)
PMID 33817379, PMID 38907342, PMID 40009403
P30CA013148 (1)