26 completed, 2 terminated, 1 enrolling by invitation, 1 recruiting. 8 Phase 3, 7 Phase 1, 6 Phase 4, 4 Phase 2, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Completed 8 |
| Phase 1 | 7 | Completed 5, Enrolling by invitation 1, Recruiting 1 |
| Phase 4 | 6 | Completed 6 |
| Phase 2 | 4 | Completed 4 |
| Not applicable | 2 | Completed 1, Terminated 1 |
| Early Phase 1 | 1 | Completed 1 |
Follow Deoxycholic Acid: new trials by email Literature Review of Deoxycholic Acid trials Research Report on Deoxycholic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intralesional Ronkyla Plus Injection for the Treatment of Superficial Lipoma Ronkyla Plus, Placebo, Kybella - Lipoma, Submental Fullness | Phase 1 | Recruiting | Glonova Pharma Co., Ltd | 56 | 2025-11-14 | 2026-10-02 |
| Assessing the Efficacy of Repeat, Monthly Treatments of Deoxycholate for NF1 Associated Cutaneous Neurofibromas (cNFs) Kybella - Neurofibromas, Cutaneous, Neurofibromatosis 1 | Phase 1 | Enrolling by invitation | Massachusetts General Hospital | 15 | 2025-04-08 | 2026-04-22 |
| A Study to Evaluate Patient Satisfaction With the Overall Face and Neck Appearance After Combined Treatment of OnabotulinumtoxinA, JUVÉDERM® Products, KYBELLA, CoolSculpting Elite and SkinMedica Products OnabotulinumtoxinA, JUVÉDERM, CoolSculpting Elite System - Facial Contouring | Phase 4 | Completed | AbbVie | 130 | 2025-01-16 | 2026-05-22 |
| Efficacy of Skin Cooling in Reducing Pain Associated With Non-invasive Treatments of Neurofibromatosis Type 1 Cutaneous Neurofibromas Deoxycholic Acid, Polidocanol, 1064nm Nd:YAG laser - Neurofibromatosis 1 | Phase 1 | Completed | Massachusetts General Hospital | 13 | 2024-03-01 | 2025-11-21 |
| Dosing and Tolerability of Deoxycholic Acid vs. Polidocanol in the Treatment of Neurofibromatosis Type 1 Cutaneous Neurofibromas Kybella, Asclera - Neurofibromatosis 1 | Phase 1 | Completed | Massachusetts General Hospital | 20 | 2022-12-06 | 2025-02-21 |
| Tolerability of Device Based Therapies for Neurofibromatosis Type 1 Cutaneous Neurofibromas Kybella, 1064nm laser, 755nm Alexandrite Laser - Cutaneous Neurofibroma | Phase 1 | Completed | Massachusetts General Hospital | 34 | 2021-06-02 | 2025-02-21 |
| Efficacy and Safety of Deoxycholic Acid Injections for Removal of Adipose Tissue in the "Bra Strap Fat" Region Deoxycholic Acid - Brassiere Strap Fat (BSF), Bra Strap Fat (BSF) | Phase 4 | Completed | Juva Skin & Laser Center | 22 | 2019-07-26 | 2021-04-01 |
| Safety and Efficacy of Deoxycholic Acid Injection for Reduction of Upper Inner Thigh Fat Deoxycholic Acid - Adiposity | Early Phase 1 | Completed | University of California, San Diego | 15 | 2019-07-05 | 2021-01-20 |
| Evaluation of the Safety and Effectiveness of BELKYRA® Inj. for the Treatment of Patients With Submental Fullness Due to Submental Fat: A Postmarketing Surveillance Study in Korea BELKYRA Inj. - Submental Fullness | Terminated | Allergan | 71 | 2018-09-07 | 2020-12-07 | |
| Submental Study (Sequential Treatment Approach) The ZELTIQ CoolSculpting System, Kybella 20 MG in 2 ML Injection - Body Fat Disorder | Phase 4 | Completed | Zeltiq Aesthetics | 16 | 2018-03-27 | 2021-12-30 |
| Kybella With Triamcinolone Injectable sodium deoxycholate, Injectable sodium deoxycholate with Triamcinolone acetate - Adiposity | Phase 4 | Completed | Goldman, Butterwick, Fitzpatrick and Groff | 30 | 2018-03-26 | 2019-05-09 |
| Safety and Efficacy of Deoxycholate Treatment of Small Fatty Deformities ( SFD) Kybella - Deformity; Skin, Fat Redistribution | Phase 4 | Completed | The Maas Clinic | 37 | 2018-02-20 | 2026-10-19 |
| Cryolipolysis Versus ATX-101 (Deoxycholic Acid) for Upper Back Fat CoolCurve, ATX-101 - Upper Back Fat | Not applicable | Terminated | Northwestern University | 8 | 2017-11-27 | 2025-05-06 |
| Subcutaneous Sodium Deoxycholate Injections With or Without Triamcinolone for Reduction of Submental Fat Sodium Deoxycholate, Triamcinolone - Fat Reduction | Phase 4 | Completed | Goldman, Butterwick, Fitzpatrick and Groff | 20 | 2016-04-01 | 2017-08-07 |
| Condition of Submental Fullness and Treatment Outcomes Registry Deoxycholic acid, Surgical Procedures, Laser Liposuction - Submental Fullness | Completed | Kythera Biopharmaceuticals | 1029 | 2015-05-11 | 2018-10-05 | |
| Safety Study of Deoxycholic Acid for the Reduction of Localized Subcutaneous Fat in the Submental Area in Subjects 65 to 75 Years of Age ATX-101, Placebo - Moderate to Severe Convexity of Submental Fat, Safety | Phase 3 | Completed | Kythera Biopharmaceuticals | 55 | 2014-04-01 | 2020-02-17 |
| Safety Study of ATX-101 (Deoxycholic Acid) in Subjects With Mild or Extreme Fullness of Submental Fat Deoxycholic Acid, Placebo - Moderate to Severe Convexity of Submental Fat, Safety | Phase 3 | Completed | Kythera Biopharmaceuticals | 93 | 2014-01-01 | 2020-02-17 |
| Patient Experience Study of Deoxycholic Acid Injection Deoxycholic Acid Injection, Placebo, Cold Compress - Moderate or Severe Submental Fullness | Phase 3 | Completed | Kythera Biopharmaceuticals | 84 | 2013-12-01 | 2015-07-28 |
| Phase 3 Study of Deoxycholic Acid Injection (ATX-101) Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area Deoxycholic acid injection, Placebo - Moderate or Severe Submental Fullness | Phase 3 | Completed | Kythera Biopharmaceuticals | 516 | 2012-03-01 | 2015-06-15 |
| Long-term 24-month Follow-up Study on Safety and Maintenance of Efficacy of ATX-101 (Sodium Deoxycholate Injection) Deoxycholic acid Injection, Placebo - Subcutaneous Fat | Completed | Allergan | 201 | 2012-02-14 | 2018-09-24 |
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Lymphoma, Follicular (9) · Neurofibromatosis 1 (4) · Lipoma (3) · Obesity (2) · Lipodystrophy (1) · Neurofibroma (1) · Skin Abnormalities (1)
Kythera Biopharmaceuticals (14) · Massachusetts General Hospital (4) · Allergan (2) · Goldman, Butterwick, Fitzpatrick and Groff (2) · AbbVie (1) · BodyAesthetic Research Center (1) · Glonova Pharma Co., Ltd (1) · Juva Skin & Laser Center (1) · Northwestern University (1) · The Maas Clinic (1) · University of California, San Diego (1) · Zeltiq Aesthetics (1)
United States (23) · Canada (5) · United Kingdom (4) · Germany (3) · Australia (2) · Belgium (2) · France (2) · Spain (2) · Italy (1) · South Korea (1) · Taiwan (1)
Frederick Beddingfield, MD, PhD (5) · Frederick Beddingfield, III, MD, PhD (3) · Richard R Anderson, MD (3) · Arisa Ortiz, MD (1) · Beta Bowen (1) · Bruce E Katz, MD (1) · Corey S Maas, M.D. (1) · Frederick Beddingfield, III, M.D., Ph.D. (1) · Frederick Beddingfield, III, M.D., PhD (1) · Frederick Beddingfield, MD. PhD (1) · Kerrie Jiang, NP (1) · Mitchel P Goldman, MD (1) · Murad Alam, MD (1) · Patricia S. Walker, M.D., Ph.D. (1)
PMID 23439063, PMID 24984785, PMID 27787269, PMID 30681793, PMID 31524342, PMID 34115682