4 completed, 1 recruiting. 5 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Recruiting 1 |
| Phase 1 | 1 | Recruiting 1 |
Follow Cutaneous Neurofibroma: new trials by email Literature Review of Cutaneous Neurofibroma trials Research Report on Cutaneous Neurofibroma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mirdametinib Monotherapy in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF). Mirdametinib - NF1, Cutaneous Neurofibroma | Phase 1 / Phase 2 | Recruiting | Johns Hopkins University | 24 | 2024-02-12 | 2026-04-13 |
| NFX-179 Topical Gel Treatment for Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF) NFX-179 gel, Vehicle gel - Cutaneous Neurofibroma, Neurofibromatosis 1 | Phase 2 | Completed | NFlection Therapeutics, Inc. | 199 | 2021-09-29 | 2026-02-17 |
| NFX-179 Topical Gel Treatment in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF) NFX-179 Gel, Vehicle Gel - Neurofibromatosis 1, Cutaneous Neurofibroma | Phase 2 | Completed | NFlection Therapeutics, Inc. | 48 | 2020-08-21 | 2022-08-09 |
| Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma Laboratory Biomarker Analysis, Selumetinib Sulfate - Cutaneous Neurofibroma, Neurofibromatosis Type 1 | Phase 2 | Completed | National Cancer Institute (NCI) | 11 | 2017-08-26 | 2023-12-06 |
| Use of Topical Liquid Diclofenac Following Laser Microporation of Cutaneous Neurofibromas in Patients With NF1 Diclofenac Sodium, Saline Solution - Neurofibromatosis 1, Cutaneous Neurofibroma | Phase 2 | Completed | Fundação Educacional Serra dos Órgãos | 7 | 2017-02-15 | 2017-10-26 |
Neurofibromatosis 1 (4) · Optic Nerve Glioma (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Genetic Diseases, Inborn (4) · Heredodegenerative Disorders, Nervous System (4) · Neoplasms (4) · Neoplasms by Histologic Type (4) · Neoplasms, Nerve Tissue (4) · Neoplastic Syndromes, Hereditary (4) · Nerve Sheath Neoplasms (4) · Nervous System Diseases (4) · Neurocutaneous Syndromes (4) · Neurodegenerative Diseases (4) · Neurofibroma (4) · Neurofibromatoses (4) · Neuromuscular Diseases (4) · Peripheral Nervous System Diseases (4)
Diclofenac (1) · Saline Solution (1) · mirdametinib (1)
NFlection Therapeutics, Inc. (2) · Fundação Educacional Serra dos Órgãos (1) · Johns Hopkins University (1) · National Cancer Institute (NCI) (1)
United States (4) · Brazil (1)
Bruce R Korf (1) · Carlos Romo, MD (1) · Guy Webster, MD, PhD (1)
PMID 33817379, PMID 38907342, PMID 40009403
P30CA013148 (1)