21 completed, 3 terminated, 3 unknown, 1 active not recruiting. 6 Phase 2, 4 Phase 3, 1 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 4, Recruiting 1, Terminated 1 |
| Phase 3 | 4 | Completed 4 |
| Not applicable | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Cushing's Syndrome: new trials by email Literature Review of Cushing's Syndrome trials Research Report on Cushing's Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Osilodrostat for the Treatment of Non-Cushing's Disease Cushing's Syndrome Osilodrostat - Cushing's Syndrome | Completed | RECORDATI GROUP | 103 | 2023-01-16 | 2025-02-10 | |
| Roll-over Study in Patients With Endogenous Cushing's Syndrome for LCI699 osilodrostat - Cushing's Syndrome | Phase 2 | Completed | RECORDATI GROUP | 127 | 2018-10-05 | 2024-12-18 |
| Novel Mediators of the Lipodystrophy and Metabolic Consequences of Cushing's Disease Treatment of Cushing's - Cushing's Syndrome | Completed | Columbia University | 8 | 2018-07-16 | 2024-06-04 | |
| Contralateral Adrenal Volume Predicts Duration of Postoperative Steroid Replacement Therapy in Non-ACTH-dependent Hypercortisolism observational diagnostic model development - Cushing's Syndrome, Postoperative | Completed | Peking University First Hospital | 121 | 2017-08-01 | 2025-12-15 | |
| Biomarker Expression in Patients With ACTH-Dependent Cushing's Syndrome Before and After Surgery Cushing's Syndrome | Completed | Corcept Therapeutics | 26 | 2016-11-01 | 2019-01-24 | |
| Study to Evaluate CORT125134 in Participants With Cushing's Syndrome CORT125134 - Cushing's Syndrome | Phase 2 | Completed | Corcept Therapeutics | 35 | 2016-06-01 | 2019-10-15 |
| Retrospective Chart Review Study of Korlym for the Treatment of ACTH Independent Cushing's Syndrome No intervention - Cushing's Syndrome | Completed | Corcept Therapeutics | 24 | 2015-10-01 | 2023-06-01 | |
| Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome Osilodrostat - Cushing's Syndrome, Ectopic Corticotropin Syndrome | Phase 2 | Completed | Novartis Pharmaceuticals | 9 | 2015-09-24 | 2020-05-06 |
| Effects of Metyrapone in Patients With Endogenous Cushing's Syndrome metyrapone - Cushing's Syndrome | Phase 3 | Completed | HRA Pharma | 50 | 2015-04-01 | 2020-09-25 |
| Prospective Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Ectopic Cushing Syndrome DOTATATE PET-CT, F-DOPA PET CT, CT scan - ACTH, Cushing's Syndrome | Phase 2 | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 80 | 2014-02-12 | 2026-10-02 |
| In Vivo Study of Interactions Between the Endocannabinoid System and the Corticotropic Axis in Man Obese, Hypercortisolism, Hydrocortisone - Cushing's Syndrome | Not applicable | Completed | University Hospital, Bordeaux | 40 | 2012-02-01 | 2026-05-22 |
| Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome? Cushing's Syndrome, Adrenal Incidentalomas | Unknown | Haukeland University Hospital | 300 | 2011-10-01 | 2016-09-26 | |
| Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome Mifepristone - Cushing's Disease, Cushing's Syndrome | Phase 3 | Completed | Corcept Therapeutics | 4 | 2010-11-01 | 2014-03-18 |
| An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome mifepristone - Cushing's Syndrome | Phase 3 | Completed | Corcept Therapeutics | 30 | 2009-07-01 | 2014-04-02 |
| A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia Cushing's syndrome confirmation - Cushing's Syndrome | Terminated | Corcept Therapeutics | 2 | 2009-02-01 | 2014-06-20 | |
| Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome Surgery - Cushing's Syndrome, Insulin Resistance | Terminated | University of Aarhus | 1 | 2008-04-01 | 2017-12-22 | |
| A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome mifepristone - Cushing's Syndrome | Phase 3 | Completed | Corcept Therapeutics | 50 | 2007-12-01 | 2013-08-22 |
| Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion Mifepristone - Cushing's Syndrome | Phase 2 | Terminated | HRA Pharma | 18 | 2007-05-15 | 2019-10-11 |
| Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy Posterior RA, Lateral transperitoneal LA - Adrenal Tumor, Pheochromocytoma | Phase 4 | Completed | Jagiellonian University | 65 | 2006-01-01 | 2013-10-10 |
| Preclinical Study Towards an Immunotherapy in Adrenocortical Carcinoma Adrenocortical Carcinoma, Cushing's Syndrome | Active not recruiting | University of Wuerzburg | 150 | 2005-09-01 | 2026-05-07 |
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Cushing Syndrome (29) · ACTH Syndrome, Ectopic (7) · Adrenal Cortex Neoplasms (5) · Pituitary ACTH Hypersecretion (5) · Pituitary Diseases (4) · Choristoma (3) · Endocrine System Diseases (3) · Hirsutism (3) · Rare Diseases (3) · Adrenocortical Carcinoma (2) · Obesity (2) · Acth-Independent Macronodular Adrenal Hyperplasia (1) · Adrenal Gland Neoplasms (1) · Adrenal Insufficiency (1) · Adrenal incidentaloma (1)
Adrenal Gland Diseases (29) · Adrenocortical Hyperfunction (28) · Endocrine System Diseases (26) · Neoplasms (10) · Endocrine Gland Neoplasms (8) · Neoplasms by Site (8) · Pathological Conditions, Signs and Symptoms (8) · Paraneoplastic Endocrine Syndromes (7) · Paraneoplastic Syndromes (7) · Adrenal Cortex Diseases (6) · Adrenal Gland Neoplasms (6) · Brain Diseases (6) · Central Nervous System Diseases (6) · Hypothalamic Diseases (6) · Nervous System Diseases (6)
Mifepristone (4) · Corlux (3) · Osilodrostat (3) · Adiposity (1) · Hydrocortisone (1) · Metyrapone (1) · Surgical Procedures, Operative (1) · fluorodopa F 18 (1) · gallium Ga 68 dotatate (1) · relacorilant (1)
Corcept Therapeutics (7) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (5) · National Center for Research Resources (NCRR) (3) · HRA Pharma (2) · Novartis Pharmaceuticals (2) · RECORDATI GROUP (2) · Columbia University (1) · Haukeland University Hospital (1) · Jagiellonian University (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Peking University First Hospital (1) · University Hospital, Bordeaux (1) · University of Aarhus (1) · University of Wuerzburg (1)
United States (19) · France (4) · Germany (4) · Italy (4) · Netherlands (3) · Poland (3) · Belgium (2) · China (2) · Hungary (2) · Japan (2) · Spain (2) · Turkey (Türkiye) (2) · Argentina (1) · Austria (1) · Brazil (1)
Lynnette K Nieman, M.D. (4) · Coleman Gross, MD (2) · Monica N. Starkman (2) · Andreas G Moraitis, MD (1) · Andreas Moraitis, M.D. (1) · Coleman Gross (1) · Coleman Gross, M.D. (1) · Deborah P Merke, M.D. (1) · Gabrielle Page-Wilson, MD (1) · Martin Fassnacht, MD (1)
PMID 25013998, PMID 26507877, PMID 18957506, PMID 22154461, PMID 22466348, PMID 23970725, PMID 24482099, PMID 25243546, PMID 32474412, PMID 32893266, PMID 34335465, PMID 35058882