28 completed. 28 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 28 | Completed 28 |
| Phase 2 | 2 | Completed 2 |
Follow Chronic Hepatitis B: new trials by email Literature Review of Chronic Hepatitis B trials Research Report on Chronic Hepatitis B
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 1) Bepirovirsen, Placebo - Chronic Hepatitis B, Hepatitis B, Chronic | Phase 3 | Completed | GlaxoSmithKline | 981 | 2022-12-07 | 2026-07-08 |
| Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 2) Bepirovirsen, Placebo - Chronic Hepatitis B, Hepatitis B, Chronic | Phase 3 | Completed | GlaxoSmithKline | 857 | 2022-12-06 | 2026-07-08 |
| A Study of Peginterferon Alfa-2b Combined With TDF in Patients With Chronic Hepatitis B Peginterferon alfa-2b injection, TDF - Chronic Hepatitis B | Phase 3 | Completed | Xiamen Amoytop Biotech Co., Ltd. | 475 | 2019-12-04 | 2024-03-05 |
| Study to Evaluate Efficacy and Safety of Switching From TDF to TAF in Adults With Chronic Hepatitis B Who Are Virologically Suppressed TAF, TDF, TAF Placebo - Chronic Hepatitis B | Phase 3 | Completed | Gilead Sciences | 490 | 2016-12-29 | 2020-09-14 |
| Study to Assess the Antiviral Activity and Safety Endpoints for the Treatment of Besifovir 150mg Compared to Tenofovir 300mg in Chronic Hepatitis B Patients Who Have Resistance to Nucleoside Analogues Besifovir 150mg, Tenofovir 300mg - Chronic Hepatitis B | Phase 3 | Completed | IlDong Pharmaceutical Co Ltd | 146 | 2015-07-01 | 2023-02-21 |
| Clinical Efficacy of ABX203 Therapeutic Vaccine in HBeAg Negative Patients With Chronic Hepatitis B ABX203 therapeutic Hepatitis B vaccine treatment arm - Chronic Hepatitis B | Phase 2 / Phase 3 | Completed | Abivax S.A. | 261 | 2014-12-01 | 2017-01-24 |
| Efficacy and Safety of Peginterferon Alfa-2b in HBeAg Positive Chronic Hepatitis B Ypeginterferon alfa-2b, Pegasys - Chronic Hepatitis B | Phase 3 | Completed | Xiamen Amoytop Biotech Co., Ltd. | 820 | 2013-03-01 | 2015-08-31 |
| Efficacy and Safety Study of Entecavir Plus Tenofovir in Patients With Chronic Hepatitis B Who Failed Previous Treatment Entecavir, Tenofovir - Chronic Hepatitis B | Phase 3 | Completed | Bristol-Myers Squibb | 144 | 2010-05-01 | 2014-12-15 |
| An Study of Efficacy and Safety of Clevudine Clevudine, Adefovir - Chronic Hepatitis B | Phase 3 | Completed | Eisai Co., Ltd. | 288 | 2010-02-01 | 2013-05-14 |
| Viral Kinetics Study of Telbivudine and Entecavir in Adults With Chronic Hepatitis B Entecavir, Telbivudine - Hepatitis B, Chronic Hepatitis B | Phase 3 | Completed | Novartis Pharmaceuticals | 44 | 2006-12-01 | 2015-03-13 |
| Adefovir Dipivoxil In Compensated Chronic Hepatitis B Patients LAM group, ADV group - Chronic Hepatitis B | Phase 3 | Completed | GlaxoSmithKline | 105 | 2006-01-01 | 2009-10-06 |
| A Study to Compare Tenofovir Disoproxil Fumarate Versus Adefovir Dipivoxil for the Treatment of HBeAg-Positive Chronic Hepatitis B TDF, ADV, TDF placebo - Chronic Hepatitis B | Phase 3 | Completed | Gilead Sciences | 266 | 2005-06-01 | 2017-03-09 |
| Telbivudine in Adults Previously Treated in Idenix-Sponsored Telbivudine Studies Telbivudine (LdT) - Chronic Hepatitis B | Phase 3 | Completed | Novartis Pharmaceuticals | 1869 | 2005-03-01 | 2020-08-21 |
| Switching Therapy From Lamivudine to Telbivudine Versus Continued Lamivudine in Adults With Chronic Hepatitis B Lamivudine, Telbivudine - Chronic Hepatitis B | Phase 3 | Completed | Novartis | 240 | 2005-02-01 | 2017-02-23 |
| A Study to Compare Tenofovir Disoproxil Fumarate Versus Adefovir Dipivoxil for the Treatment of HBeAg-Negative Chronic Hepatitis B TDF, ADV, TDF placebo - Chronic Hepatitis B | Phase 3 | Completed | Gilead Sciences | 382 | 2005-02-01 | 2017-03-07 |
| Telbivudine Versus Adefovir Dipivoxil in Adults With HBegAg-Positive, Compensated Chronic Hepatitis B Telbivudine (LdT), Adefovir Dipivoxil - Chronic Hepatitis B | Phase 3 | Completed | Novartis | 2004-11-01 | 2015-05-12 | |
| Telbivudine Versus Lamivudine in Chinese Adults With Compensated Chronic Hepatitis B telbivudine, lamivudine - Chronic Hepatitis B | Phase 3 | Completed | Novartis | 2004-07-01 | 2015-05-12 | |
| Safety and Efficacy of Adefovir Dipivoxil in Children and Adolescents With Chronic Hepatitis B Placebo (PLB), Adefovir Dipivoxil (ADV), Lamivudine - Chronic Hepatitis B | Phase 3 | Completed | Gilead Sciences | 173 | 2004-06-01 | 2012-05-22 |
| Evaluate Efficacy, Safety and PK of Adefovir Dipivoxil Liquid Suspension in Patients With Chronic Hepatitis B Adefovir Dipivoxil for oral suspension, 2 mg/mL - Chronic Hepatitis B | Phase 3 | Completed | Gilead Sciences | 48 | 2003-06-01 | 2013-10-16 |
| A Randomized, Double Blind Trial of LdT (Telbivudine) Versus Lamivudine in Adults With Compensated Chronic Hepatitis B telbivudine or lamivudine - Chronic Hepatitis B | Phase 3 | Completed | Novartis | 2003-02-01 | 2015-03-20 |
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Hepatitis B, Chronic (28) · Hepatitis B (9) · Hepatitis (2) · Hepatitis, Chronic (2) · Bronchiolitis Obliterans Syndrome (1) · HIV Infections (1) · HIV Seropositivity (1)
Blood-Borne Infections (28) · Chronic Disease (28) · Communicable Diseases (28) · DNA Virus Infections (28) · Digestive System Diseases (28) · Disease Attributes (28) · Hepadnaviridae Infections (28) · Hepatitis, Viral, Human (28) · Infections (28) · Liver Diseases (28) · Pathologic Processes (28) · Pathological Conditions, Signs and Symptoms (28) · Virus Diseases (28) · Hepatitis (26) · Hepatitis, Chronic (26)
adefovir dipivoxil (7) · Lamivudine (6) · Telbivudine (6) · Tenofovir (5) · entecavir (5) · Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination (2) · peginterferon alfa-2a (2) · ((1-((2-amino-9H-purin-9-yl)methyl)cyclopropyl)oxy)methylphosphonic acid dipivoxyl (1) · Interferon alpha-2 (1) · Ribavirin (1) · Suspensions (1) · adefovir (1) · clevudine (1) · peginterferon alfa-2b (1) · tenofovir alafenamide (1)
Gilead Sciences (5) · GlaxoSmithKline (5) · Bristol-Myers Squibb (4) · Novartis (4) · Novartis Pharmaceuticals (2) · Xiamen Amoytop Biotech Co., Ltd. (2) · Abivax S.A. (1) · Eisai Co., Ltd. (1) · Hoffmann-La Roche (1) · IlDong Pharmaceutical Co Ltd (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · National Taiwan University Hospital (1)
United States (16) · China (11) · Canada (9) · France (9) · South Korea (9) · United Kingdom (9) · Australia (8) · Spain (8) · Germany (7) · Italy (7) · New Zealand (7) · Poland (7) · Taiwan (7) · Thailand (7) · Turkey (Türkiye) (6)
Guiqiang Wang, Ph.D (1) · Guoping Yang (1) · John Flaherty, PharmD (1) · Kwang-Hyub Han, M.D, Ph.D. (1) · Ming-Yang Lai, Professor (1) · Wang Guiqiang, Ph.D (1)
PMID 19052126, PMID 20955704, PMID 23234725, PMID 23364953, PMID 23939953, PMID 25179493, PMID 25277773, PMID 25532501, PMID 25788199, PMID 25987775, PMID 27658343, PMID 28215615, PMID 30795958, PMID 31136052, PMID 42206582, PMID 16525137, PMID 16525138, PMID 17909201, PMID 18080339, PMID 18094378, PMID 19345439, PMID 20028815, PMID 23234302, PMID 25046847, PMID 27534671, PMID 32087795, PMID 33437904, PMID 39425534, PMID 41051280
2004 (2), 2009 (1), 2016 (1)