8 completed, 6 active not recruiting, 4 terminated, 4 unknown. 18 Phase 2, 4 Not applicable, 4 Phase 1, 2 Phase 3.
Follow Chronic Graft-Versus-Host Disease: new trials by email Literature Review of Chronic Graft-Versus-Host Disease trials Research Report on Chronic Graft-Versus-Host Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Establishment of Biomarker Panel For Forecasting Chronic Graft-Versus-Host Disease (cGVHD) After Allo-HSCT Detection of Inflammatory Cytokine Levels in Peripheral Blood Serum - Chronic Graft-Versus-Host Disease | Not applicable | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 1500 | 2026-04-01 | 2026-04-20 |
| A Study to Evaluate Adrixetinib (Q702) in Adults With Active Chronic Graft-Versus-Host Disease Adrixetinib - Chronic Graft-Versus-Host Disease | Phase 1 | Recruiting | Qurient Co., Ltd. | 18 | 2025-12-23 | 2025-12-30 |
| A Prospective Study of Madecassoside Tablets in Sclerotic Chronic Graft-versus-Host Disease After Allo-HSCT Madecassoside Tablets, Standard Therapy - Chronic Graft-Versus-Host Disease, Graft vs Host Disease | Phase 2 | Recruiting | WeiShi | 30 | 2025-09-01 | 2026-05-26 |
| Digital Health Intervention to Promote Quality of Life in Adults With Chronic Graft Versus Host Disease Horizons App Intervention - Chronic Graft-Versus-Host Disease, Quality of Life | Not applicable | Active not recruiting | University of Miami | 20 | 2024-12-04 | 2026-03-27 |
| Tele-Palliative Care Intervention for Patients With Chronic Graft-Versus-Host Disease Tele-palliative care visit - Chronic Graft-versus-host Disease, Chronic GVHD | Not applicable | Active not recruiting | Massachusetts General Hospital | 10 | 2024-09-09 | 2026-04-06 |
| Psychosocial Mobile App for Chronic Graft-Versus-Host Disease App, Usual Care - Chronic Graft-Versus-Host Disease, Allogeneic Stem Cell Transplant | Not applicable | Active not recruiting | Massachusetts General Hospital | 120 | 2023-01-23 | 2026-07-21 |
| MSC for Treatment of cGVHD After Allo-HSCT Mesenchymal stem cells, Glucocorticoids, cyclosporine - Chronic Graft-versus-host Disease | Phase 2 | Unknown | Nanfang Hospital, Southern Medical University | 152 | 2021-01-10 | 2020-12-31 |
| GRAVITAS-309: Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease Itacitinib, Placebo, Methylprednisolone - Chronic Graft-versus-host Disease | Phase 2 / Phase 3 | Terminated | Incyte Corporation | 155 | 2019-01-17 | 2025-10-20 |
| A Prospective Observational Study for Evaluating CGVHD Chronic Graft-Versus-Host Disease | Completed | Gruppo Italiano Trapianto di Midollo Osseo | 248 | 2017-09-01 | 2022-11-25 | |
| Treatment of Chronic Graft Versus Host Disease With Arsenic Trioxide Arsenic Trioxide Injectable Solution - Chronic Graft-Versus-Host Disease, Immune System Diseases | Phase 2 | Completed | Medsenic | 21 | 2016-12-01 | 2022-05-09 |
| Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation Baricitinib - Chronic Graft vs Host Disease, Chronic Graft-Versus-Host Disease | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 24 | 2016-11-01 | 2024-10-08 |
| Alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation MPH966 - Chronic Graft vs Host Disease, Chronic Graft-Versus-Host Disease | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 16 | 2016-04-28 | 2026-11-05 |
| Therapeutic Effects of Hydrogen on Steroid-refractory/or Steroid-dependent cGVHD Hydrogen - Chronic Graft-versus-host Disease | Phase 2 | Recruiting | Navy General Hospital, Beijing | 21 | 2016-01-01 | 2020-07-21 |
| Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease Skin punch biopsy, Peripheral blood draw - Acute Graft-versus-host Disease, Acute GVHD | Active not recruiting | Washington University School of Medicine | 22 | 2015-04-30 | 2026-03-16 | |
| Treatment of Chronic Graft-Versus-Host Disease With Mesenchymal Stromal Cells Mesenchymal Stromal Cells - Chronic Graft-Versus-Host Disease | Phase 3 | Unknown | Guangdong Provincial People's Hospital | 130 | 2014-10-01 | 2014-11-14 |
| Tear Cytokine Analysis as a Prediction or Diagnostic Marker in Ocular GvHD Chronic Graft-versus-host Disease | Completed | Yonsei University | 21 | 2014-03-01 | 2015-04-08 | |
| Safety and Efficacy Study of R932348 Ophthalmic Solution in Chronic Ocular Graft Versus Host Disease Patients(DROPS-2) R348 Ophthalmic Solution, 0.2%, R348 Ophthalmic Solution, 0.5%, Placebo Ophthalmic Solution - Chronic Graft-versus-host Disease | Phase 2 | Completed | Rigel Pharmaceuticals | 35 | 2014-03-01 | 2016-10-10 |
| Imatinib Mesylate and Mycophenolate Mofetil for Steroid-Refractory Sclerotic/Fibrotic cGVHD in Children Imatinib mesylate, Mycophenolate mofetil - Chronic Graft-versus-host Disease | Phase 2 | Terminated | Seoul National University Hospital | 9 | 2013-08-01 | 2020-10-23 |
| Donor Regulatory T Cells Infusion in Patients With Chronic Graft-versus-host Disease (GVHD) Rapamycin, T regulatory cells - Chronic Graft-Versus-Host Disease, Acute Graft-Versus-Host Disease | Phase 2 | Terminated | University of Liege | 19 | 2013-07-01 | 2022-09-22 |
| Treatment of Newly Diagnosed Moderate or Severe Chronic Graft-versus-host Disease With Prednisone and Everolimus PredEver - Chronic Graft-versus-host Disease | Phase 2 | Completed | Universitätsklinikum Hamburg-Eppendorf | 38 | 2013-03-06 | 2020-04-02 |
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Bronchiolitis Obliterans Syndrome (27) · Graft vs Host Disease (2) · Arthritis, Rheumatoid (1) · Immune System Diseases (1) · Keratoconjunctivitis Sicca (1)
Bronchial Diseases (27) · Bronchiolitis (27) · Bronchiolitis Obliterans (27) · Bronchitis (27) · Lung Diseases (27) · Lung Diseases, Obstructive (27) · Organizing Pneumonia (27) · Respiratory Tract Diseases (27) · Immune System Diseases (26) · Graft vs Host Disease (25) · Arthritis (1) · Autoimmune Diseases (1) · Conjunctival Diseases (1) · Conjunctivitis (1) · Connective Tissue Diseases (1)
Methylprednisolone (2) · Alefacept (1) · Amyloid (1) · Arsenic Trioxide (1) · Bortezomib (1) · Cyclosporine (1) · Glucocorticoids (1) · Hydrogen (1) · INCB039110 (1) · Imatinib Mesylate (1) · Interleukin-2 (1) · Methylprednisolone Acetate (1) · Methylprednisolone Hemisuccinate (1) · Mycophenolic Acid (1) · Panobinostat (1)
Dana-Farber Cancer Institute (2) · Massachusetts General Hospital (2) · Nanfang Hospital, Southern Medical University (2) · National Cancer Institute (NCI) (2) · Baylor Research Institute (1) · Grupo Espanol de trasplantes hematopoyeticos y terapia celular (1) · Gruppo Italiano Trapianto di Midollo Osseo (1) · Guangdong Provincial People's Hospital (1) · Incyte Corporation (1) · Institute of Hematology & Blood Diseases Hospital, China (1) · Medsenic (1) · Navy General Hospital, Beijing (1) · Northside Hospital, Inc. (1) · Qurient Co., Ltd. (1) · Rigel Pharmaceuticals (1)
United States (13) · China (5) · Spain (3) · Belgium (2) · Germany (2) · Italy (2) · South Korea (2) · Austria (1) · Canada (1) · Denmark (1) · Finland (1) · France (1) · Greece (1) · Israel (1) · Poland (1)
Alan Miller, MD, PhD (1) · Anne Huyhn, Dr (1) · Areej El-Jawahri, MD (1) · Attilio Olivieri, MD (1) · Carmen Regidor, MD (1) · Corey Cutler, MD (1) · Daniel R Couriel, M.D. (1) · Didier Blaise, Pr (1) · Edouard Forcade, Dr (1) · Eynav Klechevsky, Ph.D. (1) · Felipe Prosper, MD (1)
PMID 33324415, PMID 35830931, PMID 42200447
2018 (1), P01CA142106 (1)