10 completed, 5 recruiting, 4 unknown, 2 not yet recruiting. 9 Not applicable, 6 Phase 2, 5 Phase 1, 4 Phase 3, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Controlled Trial of Hydrogen Water as a Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Placebo condition, Molecular hydrogen produced by a metallic magnesium tablet, consumed 3x a day dissolved in water. Treatment duration is 16 weeks. - Chronic Fatigue Syndrome (CFS) | Not applicable | Recruiting | Fred Friedberg | 80 | 2026-08-15 | 2026-08-07 |
| Effect of Pre-exercise Inhalation of Molecular Hydrogen on Metabolic Response During Graded Exercise in Healthy Women Molecular hydrogen, Placebo - Healthy Adult Females | Not applicable | Recruiting | Palacky University | 22 | 2026-06-22 | 2026-06-25 |
| Molecular Hydrogen Inhalation: Effects on Health, Exercise Capacity and Inflammatory Response - in Vivo/in Vitro Studies Inhalation using a molecular hydrogen generator - Physiological Adaptations, Sport Performance | Not applicable | Not yet recruiting | Gdansk University of Physical Education and Sport | 250 | 2025-10-01 | 2025-08-19 |
| Hydrogen-Rich Water and Resting Metabolism in Young Adults Molecular Hydrogen, Placebo Comparator - Healthy Subjects or Volunteers | Not applicable | Not yet recruiting | University of Novi Sad | 24 | 2025-09-01 | 2025-08-01 |
| Effect of Molecular Hydrogen Inhalation on Metabolic Response During Low-intensity Exercise on a Bicycle Ergometer Molecular hydrogen, Placebo - Healthy, Respiratory Quotient Measurement | Not applicable | Completed | Palacky University | 20 | 2025-05-05 | 2026-06-25 |
| To Evaluate the Efficacy of Oral Molecular Hydrogen Supplement in Patients With Chronic Diseases Hydrogen capsules - Chronic Disease, Chronic Inflammation | Phase 2 | Unknown | HoHo Biotech | 60 | 2024-05-11 | 2024-05-07 |
| Hydrogen's Feasibility and Safety as a Therapy in ECPR Hydrogen, Usual care - Cardiac Arrest, Extracorporeal Membrane Oxygenation | Phase 1 | Recruiting | Boston Children's Hospital | 53 | 2024-03-04 | 2025-07-03 |
| Effect of Inhaled Molecular Hydrogen on Recovery Process After Downhill Walking on the Treadmill Molecular hydrogen, Placebo - Muscle Soreness, Muscle Fatigue | Not applicable | Completed | Palacky University | 14 | 2023-08-14 | 2023-12-01 |
| Hydrogen-rich Water and Treatment of Mucositis Caused by Radiation Therapy in Head and Neck Cancer Patients Hydrogen tablets, Control - Mucositis Oral | Early Phase 1 | Completed | Stony Brook University | 24 | 2022-05-25 | 2025-05-14 |
| To Evaluate the Safety of Treating Rheumatologic and Metabolic Patients With Molecular Hydrogen Supplement. Hydrogen - Autoimmune Diseases, Metabolic Disease | Phase 1 | Unknown | HoHo Biotech | 30 | 2022-01-11 | 2022-02-10 |
| To Evaluate the Safety of Treating Autoimmune Diseases With Molecular Hydrogen Supplement Hydrogen - Autoimmune Diseases | Phase 1 | Unknown | HoHo Biotech | 27 | 2021-08-13 | 2021-11-10 |
| Evaluation of the Daily Intake of 0.5 L of Water Saturated With Molecular Hydrogen for 21 Days in COVID-19 Patients Treated in Ambulatory Care MOLECULAR HYDROGEN, PLACEBO MAGNESIUM - SARS-CoV-2, Covid19 | Not applicable | Unknown | AGIR à Dom | 700 | 2021-01-22 | 2022-04-05 |
| Safety of Inhaled Hydrogen Gas Mixtures in Healthy Volunteers Hydrogen - Healthy | Phase 1 | Completed | Boston Children's Hospital | 8 | 2020-10-26 | 2021-05-06 |
| Effect H2 Water on QoL of Patients Receiving Radiotherapy for High Grade Gliomas. Hydrogen, Placebo oral tablet - Malignant Glioma | Phase 2 | Active not recruiting | Stony Brook University | 15 | 2019-10-31 | 2025-07-29 |
| Clinical Trial to Evaluate the Safety and Tolerability of Hydrogen in Patients With Parkinson's Disease Hydrogen, Placebo oral tablet - Parkinson Disease | Phase 2 / Phase 3 | Terminated | Stony Brook University | 2 | 2019-05-29 | 2023-04-12 |
| Hydrogen-rich Water for Non-alchoholic Fatty Liver Disease Hydrogen, Placebo - Non-Alcoholic Fatty Liver Disease | Not applicable | Completed | University of Novi Sad, Faculty of Sport and Physical Education | 10 | 2018-09-01 | 2019-04-16 |
| Hyperpolarized Pyruvate (13C) MR Imaging in Monitoring Patients With Prostate Cancer on Active Surveillance Hyperpolarized Carbon C 13 Pyruvate, Magnetic Resonance Spectroscopic Imaging, MRI Ultrasound Fusion Guided Biopsy - Prostate Adenocarcinoma, Prostate Cancer | Phase 2 | Recruiting | University of California, San Francisco | 60 | 2018-07-18 | 2026-05-18 |
| Hydrogen Inhalation for Health and Exercise Performance Placebo, Hydrogen - Exercise Performance | Not applicable | Completed | University of Novi Sad, Faculty of Sport and Physical Education | 20 | 2018-01-15 | 2019-02-20 |
| Neuroprotection in Acute Ischemic Stroke Hydrogen, Minocycline, Placebo Hydrogen - Stroke, Ischemic | Phase 2 / Phase 3 | Completed | Stony Brook University | 15 | 2017-08-02 | 2023-12-19 |
| Molecular Hydrogen for Cognitive Function and Performance in Elderly Molecular Hydrogen - Cognitive Impairments, Aging | Phase 3 | Completed | University of Novi Sad, Faculty of Sport and Physical Education | 13 | 2016-07-01 | 2016-10-28 |
Showing 20 of 23. Sign in to see all of them.
Autoimmune Diseases (2) · Bronchiolitis Obliterans Syndrome (1) · COVID-19 (1) · Chronic Disease (1) · Cognitive Dysfunction (1) · Fatigue Syndrome, Chronic (1) · Glioma (1) · Head and Neck Neoplasms (1) · Heart Arrest (1) · Inflammation (1) · Insulin Resistance (1) · Ischemic Stroke (1) · Metabolic Diseases (1) · Myalgia (1) · Non-alcoholic Fatty Liver Disease (1)
Stony Brook University (4) · HoHo Biotech (3) · Palacky University (3) · University of Novi Sad, Faculty of Sport and Physical Education (3) · Boston Children's Hospital (2) · AGIR à Dom (1) · Center for Health Sciences, Serbia (1) · Fred Friedberg (1) · Gdansk University of Physical Education and Sport (1) · GlaxoSmithKline (1) · Navy General Hospital, Beijing (1) · University of California, San Francisco (1) · University of Novi Sad (1)
United States (8) · Serbia (5) · Czechia (3) · Taiwan (3) · China (1) · France (1) · India (1) · Morocco (1) · Poland (1)
Adam Jarmar, Mgr (1) · Agnieszka Kowalska, MD (1) · Carine Maurer, MD,PhD (1) · Dennis Choi, MD, PhD (1) · Fred Friedberg, PhD (1) · Ivan de Kouchkovsky, MD (1) · John Kheir, MD (1) · John N Kheir, MD (1) · Kartik Mani, MD (1) · Liren Qian, M.D. (1) · Sergej Ostojic, MD, PhD (1) · Tereza Rysava (1) · Yoann Gaboreau, Dr (1)
PMID 28560519, PMID 30982748, PMID 31061920, PMID 31938004, PMID 33324415, PMID 37521410, PMID 41204320
R01CA211150 (1), R01CA300053 (1), R01EB017449 (1), U01CA232320 (1)