33 completed, 3 terminated. 22 Phase 2, 12 Phase 1, 5 Not applicable, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 22 | Completed 20, Terminated 2 |
| Phase 1 | 12 | Completed 9, Terminated 3 |
| Not applicable | 5 | Completed 5 |
| Phase 3 | 2 | Completed 2 |
Follow Childhood Chronic Myelogenous Leukemia: new trials by email Literature Review of Childhood Chronic Myelogenous Leukemia trials Research Report on Childhood Chronic Myelogenous Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies therapeutic allogeneic lymphocytes, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 2 | Completed | University of Chicago | 77 | 2013-04-04 | 2019-08-07 |
| Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Roswell Park Cancer Institute | 94 | 2012-02-28 | 2019-09-24 |
| Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies cyclophosphamide, cyclosporine, peripheral blood stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 43 | 2011-09-01 | 2017-05-19 |
| Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant supersaturated calcium phosphate rinse, placebo, questionnaire administration - Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission | Phase 3 | Completed | Children's Oncology Group | 226 | 2011-03-01 | 2019-09-17 |
| MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia Akt inhibitor MK2206, diagnostic laboratory biomarker analysis, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Acute Leukemias of Ambiguous Lineage | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2011-01-01 | 2014-04-29 |
| Infusion of Off-the-Shelf Expanded Cord Blood Cells to Augment Cord Blood Transplant in Patients With Hematologic Malignancies umbilical cord blood transplantation, fludarabine phosphate, cyclophosphamide - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Nohla Therapeutics, Inc. | 15 | 2010-08-01 | 2019-03-05 |
| Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for Cancer massage therapy, questionnaire administration, quality-of-life assessment - Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia | Not applicable | Completed | Wake Forest University Health Sciences | 80 | 2010-04-01 | 2018-07-02 |
| Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane Hydrochloride in Treating Young Patients With Relapsed or Refractory Solid Tumors, Lymphoma, or Leukemia dexrazoxane hydrochloride, doxorubicin hydrochloride, obatoclax mesylate - Acute Leukemias of Ambiguous Lineage, Acute Undifferentiated Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 22 | 2009-06-01 | 2014-05-01 |
| Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia treosulfan, fludarabine phosphate, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 96 | 2009-02-01 | 2021-06-22 |
| Fludarabine Phosphate, Melphalan, Total-Body Irradiation, Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Bone Marrow Failure Disorders fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Not applicable | Completed | Roswell Park Cancer Institute | 62 | 2009-01-14 | 2019-11-13 |
| Nilotinib and Imatinib Mesylate After Donor Stem Cell Transplant in Treating Patients With ALL or CML nilotinib, imatinib mesylate, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 40 | 2008-08-14 | 2017-08-10 |
| Donor Bone Marrow Transplant With or Without G-CSF in Treating Young Patients With Hematologic Cancer or Other Diseases allogeneic bone marrow transplantation, laboratory biomarker analysis, filgrastim - Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission | Phase 3 | Completed | Children's Oncology Group | 27 | 2007-12-31 | 2022-04-28 |
| Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies double-unit umbilical cord blood transplantation, cytogenetic analysis, bone marrow aspiration - Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Case Comprehensive Cancer Center | 14 | 2007-09-01 | 2019-01-23 |
| Busulfan, Etoposide, and Intensity-Modulated Radiation Therapy Followed By Donor Stem Cell Transplant in Treating Patients With Advanced Myeloid Cancer busulfan, etoposide, intensity-modulated radiation therapy - Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 1 / Phase 2 | Terminated | City of Hope Medical Center | 25 | 2007-06-11 | 2023-11-30 |
| Beclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer beclomethasone dipropionate, placebo, tacrolimus - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 140 | 2007-04-01 | 2021-02-03 |
| Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant lithium carbonate, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Completed | Fred Hutchinson Cancer Center | 20 | 2006-06-01 | 2017-03-07 |
| A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies cyclophosphamide, fludarabine phosphate, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | Fred Hutchinson Cancer Center | 23 | 2006-04-01 | 2015-02-11 |
| Etanercept in Treating Young Patients With Idiopathic Pneumonia Syndrome After Undergoing a Donor Stem Cell Transplant etanercept, methylprednisolone - Accelerated Phase Chronic Myelogenous Leukemia, Blastic Phase Chronic Myelogenous Leukemia | Phase 2 | Completed | Children's Oncology Group | 39 | 2006-04-01 | 2017-09-29 |
| Dasatinib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Did Not Respond to Imatinib Mesylate dasatinib, pharmacological study, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Blastic Phase Chronic Myelogenous Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 48 | 2006-03-01 | 2013-02-05 |
| Vorinostat With or Without Isotretinoin in Treating Young Patients With Recurrent or Refractory Solid Tumors, Lymphoma, or Leukemia vorinostat, isotretinoin - Childhood Acute Promyelocytic Leukemia (M3), Childhood Atypical Teratoid/Rhabdoid Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 60 | 2005-08-01 | 2014-06-17 |
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Precursor Cell Lymphoblastic Leukemia-Lymphoma (29) · Leukemia, Myeloid, Chronic-Phase (24) · Leukemia, Myeloid, Accelerated Phase (23) · Burkitt Lymphoma (21) · Congenital Abnormalities (20) · Leukemia, Lymphocytic, Chronic, B-Cell (20) · Blast Crisis (19) · Dendritic Cell Sarcoma, Interdigitating (19) · Leukemia, Myeloid, Acute (19) · Lymphoma, Large B-Cell, Diffuse (19) · Mycosis Fungoides (18) · Recurrence (18) · Sezary Syndrome (18) · Lymphoma, B-Cell, Marginal Zone (17) · Lymphoma, Follicular (17)
Hematologic Diseases (36) · Hemic and Lymphatic Diseases (36) · Neoplasms (36) · Neoplasms by Histologic Type (36) · Bone Marrow Diseases (35) · Disease Attributes (35) · Leukemia (35) · Leukemia, Myeloid (35) · Pathologic Processes (35) · Pathological Conditions, Signs and Symptoms (35) · Chronic Disease (34) · Immune System Diseases (29) · Immunoproliferative Disorders (29) · Leukemia, Lymphoid (29) · Lymphatic Diseases (29)
fludarabine phosphate (14) · Peripheral Blood Stem Cell Transplantation (12) · Whole-Body Irradiation (12) · Mycophenolic Acid (11) · Cyclosporine (10) · Transplantation (8) · Cyclophosphamide (6) · Tacrolimus (6) · Busulfan (5) · Methotrexate (5) · merphos (5) · Antilymphocyte Serum (3) · Flow Cytometry (3) · Imatinib Mesylate (3) · Methylprednisolone (3)
Fred Hutchinson Cancer Center (16) · National Cancer Institute (NCI) (9) · Children's Oncology Group (3) · Case Comprehensive Cancer Center (2) · Roswell Park Cancer Institute (2) · City of Hope Medical Center (1) · Nohla Therapeutics, Inc. (1) · University of Chicago (1) · Wake Forest University Health Sciences (1)
United States (36) · Italy (4) · Canada (3) · Germany (2) · Australia (1)
Brenda Sandmaier (4) · Maryam Fouladi (3) · Colleen Delaney (2) · George Chen (2) · Paul Martin (2) · Richard Aplenc (2) · Ann Woolfrey (1) · Anthony Stein (1) · Boglarka Gyurkocza (1) · Brenda Cooper, MD (1) · David Maloney (1) · Gregory Yanik, MD (1) · Gunnar Ragnarsson (1) · H. Joachim Deeg (1) · Hillard Lazarus (1)
PMID 32499241, PMID 18698002, PMID 19900571, PMID 21465636, PMID 23393050, PMID 26764356, PMID 28817727, PMID 35445027
P30CA015704 (10), P01CA018029 (8), U01CA097452 (3), U10CA098543 (3), P01HL036444 (2), RC2HL101844 (2), N01CM17003 (1), N01CM62202 (1), P01CA078902 (1), R24HL074445 (1), R43HL106868 (1), U01CA069856 (1), U10CA095861 (1)