11 completed, 11 terminated, 3 recruiting, 1 active not recruiting. 13 Phase 1, 11 Phase 2, 3 Not applicable, 1 Early Phase 1, 1 Phase 3.
Follow Cancer of the Pancreas: new trials by email Literature Review of Cancer of the Pancreas trials Research Report on Cancer of the Pancreas
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stereotactic Body Radiotherapy Plus FAK and RAF/MEK Inhibition in Advanced Pancreatic Adenocarcinoma Stereotactic body radiotherapy, Defactinib, Avutometinib - Pancreatic Adenocarcinoma, Cancer of the Pancreas | Phase 2 | Recruiting | Washington University School of Medicine | 36 | 2026-04-10 | 2026-04-15 |
| MK2 Inhibitor in Combination With mFOLFIRINOX for Untreated Metastatic Pancreatic Ductal Adenocarcinoma Zunsemetinib, mFOLFIRINOX - Metastatic Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer | Phase 1 | Recruiting | Washington University School of Medicine | 51 | 2025-06-13 | 2026-04-30 |
| Clinical Validation of a Blood Biomarker Test to Detect Early-Stage Pancreatic Cancer (VERIFI) PancreaSure - Cancer of the Pancreas, Pancreatic Cancer | Completed | Immunovia, Inc. | 386 | 2025-02-11 | 2025-04-27 | |
| MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial Tumor collection via biopsy, Blood collection, Diffusion basis spectrum imaging (DBSI) magnetic resonance imaging (MRI) - Locally Advanced Cervical Carcinoma, Locally Advanced Cervical Cancer | Not applicable | Recruiting | Washington University School of Medicine | 60 | 2024-01-11 | 2026-08-17 |
| Neoantigen Vaccines in Pancreatic Cancer in the Window Prior to Surgery Optimized neoantigen synthetic long peptide vaccine, Poly-ICLC - Pancreas Cancer, Pancreatic Cancer | Phase 1 | Completed | Washington University School of Medicine | 33 | 2022-12-15 | 2026-05-06 |
| NUV-868 as Monotherapy and in Combination With Olaparib or Enzalutamide in Adult Patients With Advanced Solid Tumors NUV-868, Olaparib, Enzalutamide - Advanced Solid Tumor, Ovarian Cancer | Phase 1 | Terminated | Nuvation Bio Inc. | 82 | 2022-03-29 | 2025-11-06 |
| Stereotactic Body Radiotherapy and Focal Adhesion Kinase Inhibitor in Advanced Pancreas Adenocarcinoma Adaptive stereotactic body radiation therapy, Defactinib, Tumor biopsy - Pancreas Cancer, Cancer of the Pancreas | Phase 2 | Active not recruiting | Washington University School of Medicine | 42 | 2021-08-24 | 2026-05-08 |
| Immunologic Effects of CDX-301 and CDX-1140 in Resectable Pancreatic Cancer Patients CDX-301, CDX-1140, Research blood draw - Pancreatic Cancer, Cancer of the Pancreas | Phase 2 | Terminated | Washington University School of Medicine | 16 | 2021-08-13 | 2024-10-08 |
| Targeting Pancreatic Cancer With Sodium Glucose Transporter 2 (SGLT2) Inhibition Dapagliflozin, BIOSENSE meters - Pancreas Cancer, Pancreatic Cancer | Phase 1 | Completed | Washington University School of Medicine | 15 | 2021-02-25 | 2023-02-14 |
| Neoantigen Peptide Vaccine Strategy in Pancreatic Cancer Patients Following Surgical Resection and Adjuvant Chemotherapy Neoantigen Peptide Vaccine, Poly ICLC, Blood for immune monitoring - Pancreas Cancer, Pancreatic Cancer | Phase 1 | Terminated | Washington University School of Medicine | 12 | 2020-02-13 | 2024-07-17 |
| A Pilot Study of BXCL701 in Patients With Pancreatic Cancer Talabostat Mesylate - Cancer of Pancreas, Cancer of the Pancreas | Early Phase 1 | Withdrawn | BioXcel Therapeutics Inc | 2019-10-15 | 2026-08-11 | |
| Liposomal Irinotecan Plus 5-FU / LV Combined With Paricalcitol in Patients With Advanced Pancreatic Cancer Progressed on Gemcitabine-based Therapy 5-FU, Leucovorin, Liposomal Irinotecan - Pancreatic Cancer, Pancreas Cancer | Phase 1 | Completed | Washington University School of Medicine | 20 | 2019-07-11 | 2022-10-05 |
| Self-expandable Metal Stents Versus Multiple Plastic Stents for Palliation of Biliary Obstruction Biliary stent - Bile Duct Obstruction, Extrahepatic, Cancer of the Pancreas | Not applicable | Unknown | University of Cape Town | 150 | 2019-01-01 | 2019-02-20 |
| A Phase 2 Trial of High-dose Ascorbate for Pancreatic Cancer (PACMAN 2.1) Gemcitabine, nab-paclitaxel, Pharmacological ascorbate - Pancreatic Neoplasms, Cancer of Pancreas | Phase 2 | Completed | University of Iowa | 40 | 2018-11-28 | 2026-07-23 |
| Neoantigen DNA Vaccine in Pancreatic Cancer Patients Following Surgical Resection and Adjuvant Chemotherapy Personalized neoantigen DNA vaccine, TDS-IM Electrode Array System, Peripheral blood draws - Pancreatic Cancer, Pancreas Cancer | Phase 1 | Terminated | Washington University School of Medicine | 15 | 2018-01-05 | 2023-10-10 |
| CAR T Cell Immunotherapy for Pancreatic Cancer huCART-meso cells - Pancreatic Cancer, Cancer of the Pancreas | Phase 1 | Terminated | University of Pennsylvania | 54 | 2017-09-15 | 2026-01-30 |
| Daily Online Adaptation Versus Localization for MRI-Guided SBRT for Unresectable Primary or Oligometastatic Abdominal Malignancies Online, adaptive MR-guided SBRT, Online, non-adaptive MR-guided SBRT, European Organization for Research and Treatment of Cancer (EORTC) QLQ-30 - Pancreatic Cancer, Pancreas Cancer | Phase 2 | Terminated | Washington University School of Medicine | 5 | 2017-01-19 | 2019-04-03 |
| MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors MEDI4736 - Non-Small Cell Lung Cancer, Nonsmall Cell Lung Cancer | Phase 2 | Terminated | Washington University School of Medicine | 4 | 2016-09-12 | 2018-11-06 |
| Epidural Analgesia Use in Pancreatic Resections Bupivacaine - Cancer of Pancreas, Cancer of the Pancreas | Phase 1 | Completed | Washington University School of Medicine | 23 | 2016-06-07 | 2020-03-12 |
| BVD-523 Plus Nab-paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Cancer BVD-523, Nab-paclitaxel, Gemcitabine - Pancreatic Cancer, Cancer of Pancreas | Phase 1 | Terminated | Washington University School of Medicine | 18 | 2016-06-06 | 2021-04-21 |
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Pancreatic Neoplasms (28) · Adenocarcinoma (2) · Breast Neoplasms (2) · Neoplasms (2) · Ovarian Neoplasms (2) · Anorexia (1) · Bile Duct Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Non-Small-Cell Lung (1) · Cholestasis, Extrahepatic (1) · Colorectal Neoplasms (1) · Endocrine Gland Neoplasms (1) · Jaundice (1) · Kidney Neoplasms (1) · Neoplasm Metastasis (1)
Digestive System Diseases (28) · Digestive System Neoplasms (28) · Endocrine System Diseases (28) · Neoplasms by Site (28) · Pancreatic Diseases (28) · Endocrine Gland Neoplasms (27) · Neoplasms (26) · Carcinoma (3) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Genital Diseases (3) · Genital Diseases, Female (3) · Genital Neoplasms, Female (3) · Neoplasms by Histologic Type (3) · Neoplasms, Glandular and Epithelial (3)
Gemcitabine (5) · 130-nm albumin-bound paclitaxel (2) · Albumin-Bound Paclitaxel (2) · Blood Specimen Collection (2) · Radiosurgery (2) · defactinib (2) · durvalumab (2) · poly ICLC (2) · Ascorbic Acid (1) · Bupivacaine (1) · Capecitabine (1) · Fluorouracil (1) · Leucovorin (1) · Magnetic Resonance Imaging (1) · Monitoring, Immunologic (1)
Washington University School of Medicine (15) · Amgen (1) · Augusta University (1) · BioXcel Therapeutics Inc (1) · Centre Hospitalier Universitaire de Nice (1) · Emory University (1) · Immunovia, Inc. (1) · NantCell, Inc. (1) · National Cancer Institute (NCI) (1) · Nuvation Bio Inc. (1) · University of Cape Town (1) · University of Iowa (1) · University of Pennsylvania (1) · University of Texas Southwestern Medical Center (1)
United States (25) · Australia (2) · France (2) · Austria (1) · Belgium (1) · Brazil (1) · Bulgaria (1) · Canada (1) · Czechia (1) · Denmark (1) · Finland (1) · Germany (1) · Greece (1) · Hong Kong (1) · Hungary (1)
William E Gillanders, M.D. (2) · Andrea Wang-Gillam, M.D., Ph.D. (1) · BioXcel MM, MD (1) · Carl DeSelm, M.D., Ph.D. (1) · Daniel Laheru, M.D. (1) · Joseph J. Cullen, MD, FACS (1) · Kian-Huat Lim, M.D, Ph.D. (1) · Kian-Huat Lim, M.D. (1) · Kian-Huat Lim, M.D., Ph.D. (1) · Mark O'Hara, MD (1) · Michael Bottros, M.D. (1) · Michael C Roach, M.D. (1) · Michael Waters, M.D., Ph.D. (1) · Moh'd Khushman, M.D. (1)
PMID 27475674, PMID 28939558, PMID 29374667, PMID 36427020, PMID 37202813, PMID 37598000, PMID 39369582, PMID 40829595
P50CA196510 (4), P01CA217797 (1), P30CA086862 (1), P50CA272213 (1), R01CA248917 (1), R01CA262506 (1), U01CA140206 (1), U54CA274318 (1)