404 completed. 404 Phase 1, 73 Phase 2.
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Trial Phase Status Sponsor Enrollment Start Updated
A Study to Investigate How Budesonide and Formoterol Move Through the Body (Pharmacokinetics) When Delivered With Different Devices in Participants Aged 4 to Less Than 12 Years Old With Asthma Budesonide/formoterol fumarate Aerosphere, Budesonide/formoterol fumarate pMDI - Asthma Phase 1 Completed 16 2026-03-05 2026-07-15 Bioequivalence Study of AJU-R713 and R713R in Healthy Adult Volunteers AJU-R713, R713R - Bronchial Asthma, Perennial Allergic Rhinitis Phase 1 Completed 62 2025-12-12 2026-09-18 A Clinical Study to Evaluate SM17 in Healthy Participants SM17, SM17 placebo - Atopic Dermatitis, Asthma Phase 1 Completed 30 2025-10-14 2026-04-06 A Study of Inhaled AZD8630 in Adolescents With Asthma AZD8630, Dry powder inhaler - Asthma Phase 1 Completed 10 2025-06-11 2025-10-14 A Study to Evaluate the Safety and Tolerability of Multiple Dose of IBI3002 in Healthy and Asthmatic Participants Placebo, IBI3002 - Asthma Phase 1 Completed 44 2025-05-14 2026-06-09 Phase 1 Study to Evaluate the Safety and Drug-Drug Interactions in Healthy Adult Participants AG2203L, AG2203E, AG2203L+AG2203E - Acute Bronchitis Phase 1 Completed 36 2025-03-28 2026-09-01 A Study to Assess the Potential for Airway Sensitivity Reactions With Propellants HFA-152a (Test) and HFA-134a (Reference) Administered Via Pressurized Inhalers in Adults With Mild Asthma HFA-152A propellant, HFA-134A propellant - Asthma Phase 1 Completed 20 2025-03-11 2026-08-21 Study to Evaluate the Pharmacokinetics and Pharmacodynamics of AZD4604 Given Via the Turbuhaler® Device in Adults With Mild Asthma. AZD4604, Placebo, Genuair - Asthma Phase 1 Completed 28 2025-02-27 2025-06-05 A Safety, Pharmacokinetic, and Pharmacodynamic Study of Once Daily Inhaled AZD8630 in Adults With Asthma AZD8630, Placebo, Saphira device - Asthma Phase 1 Completed 24 2025-01-28 2025-10-03 A Study to Investigate the Exposure of Budesonide, Glycopyrronium, and Formoterol (BGF) Delivered by Hydrofluoroolefin (HFO) Propellant Metered Dose Inhaler (MDI) Compared to a Hydrofluoroalkane (HFA) Propellant MDI in Healthy Adults Treatment A: BGF MDI HFO, Treatment B: BGF MDI HFA - Healthy Participants Phase 1 Completed 105 2025-01-23 2025-06-05 Study of Inhaled RCT1100 in Adults With PCD Caused by Pathogenic Mutations in the DNAI1 Gene to Measure Mucociliary Clearance RCT1100 - Primary Ciliary Dyskinesia (PCD) Phase 1 Completed 14 2024-10-22 2026-04-30 A Study to Assess the Safety, Tolerability, Ciliary Rescue, and Pharmacodynamics of RCT1100 in Adults With PCD RCT1100 - Primary Ciliary Dyskinesia Phase 1 Completed 7 2024-09-20 2025-10-08 A Study to Investigate the Relative Bioavailability of AZD8630 Following a Device and Formulation Transition in Healthy Participants. AZD8630 (test formulation) via test inhaler, AZD8630 (reference formulation) via Monodose inhaler, Test inhaler - Healthy Participants Phase 1 Completed 32 2024-08-06 2024-10-17 Study of the Effect of HFA-152a and HFA-134a Propellants on Mucociliary Clearance in Healthy Participants HFA-152a, HFA-134a, Radiolabeled saline solution - Asthma Phase 1 Completed 24 2024-07-29 2026-04-14 Safety, Tolerability, and Pharmacokinetics of PA9159 Inhalation Aerosol in Healthy Adult Subjects PA9159 Inhalation aerosol, 60 μg one day treatment, PA9159 Inhalation aerosol, 120 μg one day treatment, PA9159 Inhalation aerosol, 240 μg one day treatment - Bronchial Asthma Phase 1 Completed 40 2024-07-22 2025-12-30 A Study to Compare the Pharmacokinetics (PK) of Salbutamol Administered Via Metered Dose Inhalers (MDI) Containing Propellants HFA-152A (Test) or HFA-134A (Reference) in Healthy Participants Aged 18 to 55 Inclusive Salbutamol HFA-152a, Salbutamol HFA-134a - Asthma, Healthy Participants Phase 1 Completed 60 2024-06-04 2026-01-12 Pharmacokinetic Profile and Safety of Fluticasone Propionate and Albuterol Sulfate in Combination When Compared to Fluticasone Propionate Multidose Dry Powder Inhaler (Fp MDPI) in Children Aged 4 to 11 Years Old TEV-56248, Fp MDPI - Asthma Phase 1 Completed 30 2024-05-16 2026-08-04 A Study to Investigate Relative Bioavailability of Two Different Dosage Forms for Tozorakimab Via Subcutaneous Administration in Healthy Volunteers Tozorakimab - Healthy Participants Phase 1 Completed 46 2024-04-08 2024-09-19 A Double-Blind, Active-Controlled, Multiple-Ascending Dose Study of Aerosolized RSP-1502 in Subjects With CF and Chronic PA Lung Infection RSP-1502, Tobramycin inhalation solution - Cystic Fibrosis Lung, Respiratory Infections, Recurrent, Chronic Phase 1 / Phase 2 Completed 71 2024-04-01 2026-06-25 Effect of Halotherapy in Children With Asthma Halotherapy (Salt Therapy) - Therapy, Oxygen Inhalation Phase 1 Completed 70 2024-03-06 2024-08-02
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Narrower conditions Asthma (312) · Bronchiolitis Obliterans Syndrome (53) · Pulmonary Disease, Chronic Obstructive (43) · Hypersensitivity (17) · Graft vs Host Disease (11) · Neoplasms (11) · Bronchiectasis (10) · Lung Diseases (9) · Leukemia (8) · Rhinitis, Allergic, Perennial (8) · Bronchial Neoplasms (7) · Lung Neoplasms (7) · Bronchiolitis (6) · Bronchiolitis Obliterans (6) · Carcinoma, Non-Small-Cell Lung (6)
Broader conditions Respiratory Tract Diseases (398) · Lung Diseases (381) · Lung Diseases, Obstructive (379) · Immune System Diseases (364) · Hypersensitivity, Immediate (315) · Respiratory Hypersensitivity (314) · Hypersensitivity (298) · Pathological Conditions, Signs and Symptoms (74) · Bronchitis (66) · Pathologic Processes (66) · Bronchiolitis (57) · Disease Attributes (53) · Organizing Pneumonia (53) · Chronic Disease (52)
Interventions Budesonide (23) · Fluticasone (11) · montelukast (11) · Charcoal (10) · Formoterol Fumarate (8) · Albuterol (7) · Budesonide, Formoterol Fumarate Drug Combination (6) · Fluticasone-Salmeterol Drug Combination (6) · Salmeterol Xinafoate (6) · fluticasone furoate (6) · Saline Solution (5) · Injections, Subcutaneous (4) · Moxifloxacin (4) · Omalizumab (4) · Prednisone (4)
Sponsors GlaxoSmithKline (58) · AstraZeneca (36) · Orion Corporation, Orion Pharma (13) · Chiesi Farmaceutici S.p.A. (9) · Merck Sharp & Dohme LLC (9) · Boehringer Ingelheim (7) · Hoffmann-La Roche (7) · MedImmune LLC (7) · National Institute of Allergy and Infectious Diseases (NIAID) (7) · University of North Carolina, Chapel Hill (7) · Intech Biopharm Ltd. (6) · Amgen (5) · Novartis Pharmaceuticals (5) · Teva Branded Pharmaceutical Products R&D, Inc. (5) · Pfizer (4)
Countries United States (144) · United Kingdom (80) · Germany (45) · Australia (34) · China (25) · Canada (12) · New Zealand (12) · Netherlands (11) · Finland (10) · Spain (9) · Belgium (8) · South Korea (8) · France (6) · Russia (6) · Taiwan (6)
Top investigators Robert Wood, MD (5) · Cecil Charles, PhD (3) · David B Peden, MD, MS (3) · John Matthews, MBBS, MCRP, PhD (3) · Leena Mattila, MD, PhD (3) · Ulla Sairanen, MSc (3)
Results publications PMID 24184147 , PMID 32907575 , PMID 40185989 , PMID 11163535 , PMID 11728816 , PMID 16186597 , PMID 17717202 , PMID 18214942 , PMID 18244953 , PMID 19446146 , PMID 19717725 , PMID 19750190 , PMID 19821718 , PMID 19944580 , PMID 20122281 , PMID 20976161 , PMID 21057005 , PMID 21639872 , PMID 21729182 , PMID 22129252 , PMID 22544892 , PMID 22616628 , PMID 22772084 , PMID 22955319 , PMID 22989372 , PMID 23102735 , PMID 23176889 , PMID 23706713 , PMID 23861248 , PMID 23903014 , PMID 24093504 , PMID 24568613 , PMID 24731015 , PMID 24846652 , PMID 25485197 , PMID 25614148 , PMID 25700806 , PMID 26059242 , PMID 26252343 , PMID 26830468 , PMID 26945226 , PMID 27127998 , PMID 27464582 , PMID 27849125 , PMID 28072473 , PMID 28193704 , PMID 28455782 , PMID 28734844 , PMID 28924018 , PMID 28933971
NIH funding 2016 (10) , 2014 (5) , 2015 (5) , 2019 (4) , 2009 (3) , 2018 (3) , 2017 (2) , P01AT002620 (2) , P01HL158507 (2) , U19AI095261 (2) , 2023 (1) , P01AT002647 (1) , P50AT002782 (1) , R03NR009361 (1) , R21AT007357 (1)