17 completed, 3 recruiting, 3 unknown, 2 terminated. 8 Not applicable, 4 Phase 2, 3 Phase 1, 3 Phase 3, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 3, Recruiting 2, Terminated 2, Unknown 1 |
| Phase 2 | 4 | Completed 3, Not yet recruiting 1 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 3 | Completed 3 |
| Phase 4 | 2 | Completed 1, Unknown 1 |
Follow Bone Metastasis: new trials by email Literature Review of Bone Metastasis trials Research Report on Bone Metastasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Plasma Exosomal RNA Signature for Prostate Cancer Bone Metastasis Prostate Cancer (Diagnosis), Bone Metastasis | Recruiting | Xijing Hospital | 1000 | 2026-03-12 | 2026-04-28 | |
| Spinal Palliation in Irradiation for Neoplastic Analgesia and Life Quality Sparing irradiation, Conventional spinal irradiation - Bone Metastasis, Oncology Pain | Not applicable | Recruiting | Institut de Cancérologie de Lorraine | 598 | 2025-07-02 | 2025-09-23 |
| Non Steroidal Anti-inflammatory Drugs in the Prevention of Bone Pain Flares After Palliative Radiotherapy Naproxen (Proxen S), Placebo, Esomeprazole 20mg once daily - Bone Pain Flare, Bone Metastasis | Phase 2 | Not yet recruiting | American University of Beirut Medical Center | 385 | 2025-04-01 | 2025-04-04 |
| Biomolecular Markers of Bone Metastasis Biomolecular profile of bone metastases - Bone Metastasis | Not applicable | Recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 160 | 2024-09-17 | 2025-02-04 |
| Feasibility Study of FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases FLASH Radiotherapy - Bone Metastasis | Not applicable | Completed | Varian, a Siemens Healthineers Company | 10 | 2020-11-03 | 2024-07-31 |
| Zoledronic Acid Combined Radiotherapy for Bone Metastasis of Non-small Cell Lung Cancer Zoledronic acid, Radiotherapy - Non-small Cell Lung Cancer, Bone Metastasis | Phase 4 | Unknown | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 280 | 2019-06-01 | 2019-01-16 |
| Spinal Metastasis as the First Presentation of Lung Malignancy: Clinical Characteristics and Postoperative Survival Lung Cancers, Bone Metastasis | Completed | Guangdong Provincial People's Hospital | 139 | 2018-01-01 | 2025-08-03 | |
| Validation of Radio-induced Damage Biomarkers blood and urines samples - Bone Metastasis, Malignant Hemopathy | Not applicable | Terminated | Centre Hospitalier Universitaire de Saint Etienne | 16 | 2017-06-22 | 2022-02-22 |
| Evaluation of Sodium Fluoride PET in the Identification of Bone Metastases in Patients Having Undergone a Choline PET for Occult Recurrence of Prostatic Adenocarcinoma Sodium fluoride PET - Bone Metastasis | Not applicable | Unknown | Central Hospital, Nancy, France | 110 | 2016-02-01 | 2016-08-24 |
| The OPTIMAL Study - A Prospective Cohort of Patients With Bone Metastases of the Long Bones Stabilisation of (impending) pathological fracture, Radiotherapy of bone metastasis - Bone Metastasis | Unknown | Leiden University Medical Center | 900 | 2016-01-01 | 2016-09-19 | |
| Phase 3 Study on the Efficacy and Safety of Tanezumab in Patients With Cancer Pain Due to Bone Metastasis Who Are Taking Background Opioid Therapy Tanezumab - Bone Metastasis, Cancer Pain | Phase 3 | Completed | Pfizer | 156 | 2015-10-28 | 2023-02-16 |
| Pain Management With Pecfent in the Prevention of Pain Induced by Position in Radiotherapy fentanyl transmucosal, Placebo - Bone Metastasis | Phase 3 | Completed | Centre Henri Becquerel | 39 | 2015-05-22 | 2026-01-02 |
| Bone Pain Score Validation Initiative Bone Metastasis | Completed | iOMEDICO AG | 370 | 2014-12-01 | 2018-08-10 | |
| A Study to Collect Data About Analgesia in Patients With Bone Metastasis Questionnaires completion, Clinical Pain Assessments - Bone Metastasis | Completed | Tools4Patient | 74 | 2014-07-01 | 2019-08-19 | |
| A Trial of MBC-11 in Patients With CIBD MBC-11 - Bone Metastasis | Phase 1 | Completed | Osteros Biomedica Ltd | 16 | 2014-07-01 | 2016-03-29 |
| Efficacy of Radiotherapy in Combination With Zoledronic Acid in Bone Metastasis Patients With Gastrointestinal Tumors Zoledronic acid, Radiotherapy - Bone Metastasis, Gastrointestinal Cancer | Phase 2 | Completed | Severance Hospital | 60 | 2014-06-01 | 2017-03-29 |
| A Phase IV Post Approval Clinical Study of ExAblate Treatment of Metastatic Bone Tumors for the Palliation of Pain ExAblate MRgFUS - Bone Metastasis | Not applicable | Completed | InSightec | 32 | 2013-09-01 | 2023-04-07 |
| Comparison of NaF PET-CT and Diffusion MRI in the Diagnosis of Bone Metastases (IMMETAOS) PET-CT, MRI - Cancer, Bone Metastasis | Not applicable | Completed | Institut Jean-Godinot | 13 | 2013-07-01 | 2016-08-24 |
| Survey of XGEVA® Presrcibers in Europe to Evaluate Their Knowledge of the Summary of Product Characteristics Pertaining to Osteonecrosis of the Jaw Physician Survey - Solid Tumours, Bone Metastasis | Completed | Amgen | 420 | 2013-02-04 | 2018-01-09 | |
| Antalgic Treatment of Painful Bone Metastases by US-guided High Intensity Focused Ultrasound (HIFU) HIFU - Bone Metastasis | Phase 1 | Completed | Theraclion | 3 | 2012-12-01 | 2014-04-16 |
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Breast Neoplasms (3) · Pain (3) · Prostatic Neoplasms (3) · Cancer Pain (2) · Neoplasm Metastasis (2) · Neoplasms (2) · Carcinoma, Non-Small-Cell Lung (1) · Disease (1) · Gastrointestinal Neoplasms (1) · Lung Neoplasms (1) · Multiple Myeloma (1)
Neoplasms (9) · Neoplasms by Site (8) · Pathological Conditions, Signs and Symptoms (8) · Neurologic Manifestations (5) · Signs and Symptoms (5) · Breast Diseases (3) · Genital Diseases (3) · Genital Diseases, Male (3) · Genital Neoplasms, Male (3) · Male Urogenital Diseases (3) · Pathologic Processes (3) · Prostatic Diseases (3) · Skin Diseases (3) · Skin and Connective Tissue Diseases (3) · Urogenital Diseases (3)
Zoledronic Acid (4) · Radiotherapy (3) · Administration, Mucosal (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · Blood Specimen Collection (1) · Chemoradiotherapy (1) · Esomeprazole (1) · Fentanyl (1) · Naproxen (1) · Positron Emission Tomography Computed Tomography (1) · tanezumab (1)
Philips Healthcare (2) · American University of Beirut Medical Center (1) · Amgen (1) · Central Hospital, Nancy, France (1) · Centre Henri Becquerel (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (1) · Guangdong Provincial People's Hospital (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · InSightec (1) · Institut Jean-Godinot (1) · Institut de Cancérologie de Lorraine (1) · International Atomic Energy Agency (1) · Leiden University Medical Center (1) · Novartis Pharmaceuticals (1)
France (6) · China (3) · South Korea (3) · United Kingdom (3) · Brazil (2) · Canada (2) · Germany (2) · Israel (2) · Netherlands (2) · Spain (2) · United States (2) · Algeria (1) · Argentina (1) · Australia (1) · Austria (1)
Alvaro Pereira (1) · Andrea Sambri, MD (1) · Bassem Youssef, MD (1) · Elena Fidarova, MD (1) · Ge Wang, Doctor (1) · Greg Czarnota, M.D. (1) · Ian F Tannock, MD, PhD (1) · John Breneman, MD (1) · Lara Hilal, MD (1) · Norbert Marschner, MD (1)
PMID 11683656, PMID 17081915, PMID 19484483, PMID 20220181, PMID 20562730, PMID 20818875, PMID 21074335, PMID 21489705, PMID 23053582, PMID 23874586, PMID 25624439, PMID 29874105, PMID 30231381, PMID 30413669, PMID 33362171, PMID 35661676, PMID 35736814, PMID 36206189, PMID 36273324, PMID 37343145, PMID 38788923, PMID 4723349, PMID 858248