261 completed. 261 Phase 3, 22 Phase 2.
By phase and status
Follow Blood Coagulation Disorders: new trials by email Literature Review of Blood Coagulation Disorders trials Research Report on Blood Coagulation Disorders
Trials (filtered) newest first · largest first
All 261 trials
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
Recombinant Single-chain Factor VIII (rVIII-SingleChain) in Chinese Participants With Hemophilia A Previously Treated With FVIII Products Recombinant single-chain factor VIII (rVIII-SingleChain) - Congenital Hemophilia A | Phase 3 | Completed | 62 | 2025-01-09 | 2026-10-23 |
Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Chinese Subjects With Hemophilia B Previously Treated With FIX Therapy Recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) - Hemophilia B | Phase 3 | Completed | 23 | 2024-07-28 | 2026-07-23 |
Phase 3 Clinical Project of Pegylated Recombinant Human Coagulation Factor VIII-Fc Fusion Protein FRSW117 - Severe Hemophilia A | Phase 3 | Completed | 124 | 2023-12-27 | 2026-09-09 |
A Study Evaluating Physical Activity and Joint Health in Severe Haemophilia A Patients ≥12 Years Treated Once Weekly With Efanesoctocog Alfa Efanesoctocog alfa - Hemophilia A, Severe | Phase 3 | Completed | 93 | 2023-07-31 | 2026-07-02 |
rFVIII-Fc (Produced by AryoGen Pharmed Co.) Pharmacokinetic Study Factor VIII, recombinant human with Fc fusion (rFVIII-Fc) - Severe Hemophilia A | Phase 3 | Completed | 50 | 2023-07-22 | 2023-11-18 |
A Research Study Looking at How Safe it is to Switch From Emicizumab to Mim8 in People With Haemophilia A (FRONTIER 5) NNC0365-3769 (Mim8) PPX - Haemophilia A, Haemophilia A With Inhibitors | Phase 3 | Completed | 61 | 2023-06-26 | 2025-12-08 |
A Study of Adynovate in Previously Treated Chinese Teenagers and Adults With Severe Hemophilia A Adynovate - Hemophilia A | Phase 3 | Completed | 37 | 2023-03-27 | 2025-05-01 |
Caplacizumab and Immunosuppressive Therapy Without Firstline Therapeutic Plasma Exchange in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura Caplacizumab, Corticosteroids, anti-CD20 antibody - Thrombotic Thrombocytopenic Purpura | Phase 3 | Completed | 51 | 2022-11-21 | 2025-12-30 |
The Combination of ATRA and Eltrombopag as the Treatment of Steroid-resistant/Relapse ITP Based on MSC-C5b-9 all-trans retinoic acid, Eltrombopag - Purpura, Thrombocytopenic, Idiopathic | Phase 3 | Completed | 96 | 2022-10-12 | 2025-09-09 |
Intravenous Immunoglobulin (IVIG, Bioven) Efficacy and Safety in Chronic Primary Immune Thrombocytopenia (ITP) in Adults Intravenous immunoglobulin (IVIG), 10% solution for infusion - Primary Immune Thrombocytopenia | Phase 3 | Completed | 32 | 2022-07-26 | 2024-09-23 |
Evaluation of Avatrombopag for the Treatment of Thrombocytopenia in Japanese Adults With Chronic ITP Avatrombopag Oral Tablet - Immune Thrombocytopenia | Phase 3 | Completed | 19 | 2022-06-15 | 2026-06-03 |
A Research Study Investigating Nonacog Beta Pegol (N9-GP) for Treatment and Prevention of Bleedings in Chinese People With Haemophilia B Nonacog beta pegol - Haemophilia B | Phase 3 | Completed | 30 | 2022-05-18 | 2026-01-12 |
Study of the Safety and Immunogenicity of Long-term GNR-069 Therapy in ITP Patients GNR-069 - Idiopathic Thrombocytopenic Purpura | Phase 3 | Completed | 160 | 2022-03-28 | 2024-06-21 |
A Study to Learn How Safe the Study Treatment BAY94-9027 is and How it Affects the Body in Previously Treated Children Aged 7 to Less Than 12 Years With Severe Hemophilia A, a Genetic Bleeding Disorder That is Caused by the Lack of a Protein Called Clotting Factor 8 (FVIII) in the Blood Damoctocog alfa pegol (Jivi, BAY94-9027) - Treatment of Bleeding, Prophylaxis of Bleeding | Phase 3 | Completed | 36 | 2022-03-23 | 2026-07-02 |
Evaluation of Glucocorticoids Plus Rituximab in Patients With Newly-Diagnosed or Relapsing IgA Vasculitis Rituximab Injection, placebo - IgA Vasculitis | Phase 3 | Completed | 75 | 2022-03-11 | 2026-06-11 |
A Research Study Investigating Mim8 in Adults and Adolescents With Haemophilia A With or Without Inhibitors NNC0365-3769 (Mim8) - Haemophilia A, Haemophilia A With Inhibitors | Phase 3 | Completed | 281 | 2021-12-02 | 2025-12-08 |
Phase III Study on HMPL-523 for Treatment of ITP HMPL-523, Placebo - Primary Immune Thrombocytopenia (ITP) | Phase 3 | Completed | 272 | 2021-10-27 | 2026-05-04 |
Efficacy and Safety of Turoctocog Alfa Pegol (N8-GP) for Prophylaxis and Treatment of Bleeding Episodes in Previously Treated Chinese Patients With Haemophilia A (pathfinder10) turoctocog alfa pegol (N8-GP) - Haemophilia A | Phase 3 | Completed | 36 | 2021-09-27 | 2026-01-06 |
Efficacy, PK, Immunogenicity and Safety of Wilate in Severe Von Willebrand Disease (VWD) Patients <6 Years of Age Wilate - Von Willebrand Disease | Phase 3 | Completed | 12 | 2021-09-22 | 2026-02-20 |
Comparative Study of Clinical Efficacy and Safety of GNR-069 and Nplate in Patients With ITP GNR-069, Nplate - Idiopathic Thrombocytopenic Purpura | Phase 3 | Completed | 160 | 2021-09-09 | 2024-03-06 |
Showing 20 of 261. Sign in to see all of them.
Narrower conditions
Hemophilia A (99) · Purpura, Thrombocytopenic, Idiopathic (68) · Hemophilia B (43) · Thrombocythemia, Essential (18) · Thrombocytopenia (18) · Lymphoma, Follicular (12) · Polycythemia Vera (12) · Primary Myelofibrosis (12) · von Willebrand Diseases (12) · Blast Crisis (11) · Burkitt Lymphoma (11) · Immunoblastic Lymphadenopathy (11) · Leukemia, Lymphocytic, Chronic, B-Cell (11) · Leukemia, Myeloid, Accelerated Phase (11)
Broader conditions
Hemic and Lymphatic Diseases (261) · Hematologic Diseases (252) · Hemorrhagic Disorders (240) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (167) · Genetic Diseases, Inborn (157) · Blood Coagulation Disorders, Inherited (154) · Coagulation Protein Disorders (147) · Blood Platelet Disorders (105) · Pathologic Processes (96) · Pathological Conditions, Signs and Symptoms (96) · Signs and Symptoms (87) · Immune System Diseases (85) · Cytopenia (80) · Skin Manifestations (79)
Interventions
Factor VIII (37) · romiplostim (13) · Factor IX (12) · Immunoglobulins, Intravenous (11) · Rituximab (11) · F8 protein, human (10) · eltrombopag (10) · Dexamethasone (8) · BAX 855 (7) · emicizumab (7) · nonacog beta pegol (6) · von Willebrand Factor (6) · Prednisone (5) · fitusiran (5) · gamma-Globulins (5)
Sponsors
Baxalta now part of Shire (27) · CSL Behring (19) · Novo Nordisk A/S (19) · Octapharma (14) · Bio Products Laboratory (13) · Amgen (9) · Bayer (9) · Hoffmann-La Roche (8) · Wyeth is now a wholly owned subsidiary of Pfizer (8) · Bioverativ Therapeutics Inc. (7) · Pfizer (6) · Genzyme, a Sanofi Company (5) · Shandong University (5) · Bioverativ, a Sanofi company (4) · GlaxoSmithKline (4)
Countries
United States (139) · United Kingdom (93) · Italy (84) · Germany (83) · Spain (79) · Poland (73) · France (71) · Japan (62) · Canada (60) · Russia (59) · Ukraine (53) · Australia (52) · Netherlands (51) · Turkey (Türkiye) (51) · Austria (50)
Top investigators
Renchi Yang (3)
Results publications
PMID 40750723, PMID 19216617, PMID 26196195, PMID 35939785, PMID 19671919, PMID 26931631, PMID 33995988, PMID 36848635, PMID 39091324, PMID 40386832, PMID 18242413, PMID 21533818, PMID 22117897, PMID 22494019, PMID 24335249, PMID 25273984, PMID 26679394, PMID 27002680, PMID 32293786, PMID 33719084, PMID 34922648, PMID 40099428, PMID 12401245, PMID 12944568, PMID 15459300, PMID 16973975, PMID 17077333, PMID 17397698, PMID 18208533, PMID 18625626, PMID 18689371, PMID 18697901, PMID 19005182, PMID 19386744, PMID 19635187, PMID 19731307, PMID 19776145, PMID 19787352, PMID 19846889, PMID 20130241, PMID 20237066, PMID 20719580, PMID 20841509, PMID 20863431, PMID 21628633, PMID 22409309, PMID 22476554, PMID 22480131, PMID 22764744, PMID 22776196
NIH funding
2009 (11), 2016 (10), 2017 (9), 2023 (7), 2008 (5), 2019 (5), 2014 (4), 2015 (4), 2018 (3), 2004 (2), P01CA108671 (1), P30CA068485 (1), R01AG019147 (1), R01CA127655 (1), R01HL069272 (1)