39 completed, 14 terminated, 3 withdrawn, 2 active not recruiting. 30 Phase 1, 24 Phase 2, 6 Not applicable, 1 Phase 3.
Follow Blastic Phase Chronic Myelogenous Leukemia: new trials by email Literature Review of Blastic Phase Chronic Myelogenous Leukemia trials Research Report on Blastic Phase Chronic Myelogenous Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia Bosutinib - Philadelphia Chromosome Positive CML, Accelerated Phase Chronic Myelogenous Leukemia | Phase 1 / Phase 2 | Active not recruiting | Children's Oncology Group | 60 | 2020-07-06 | 2026-10-01 |
| CALLS: CML and Ph+ALL Low Level Mutation Prevalence Survey Chronic Phase Chronic Myelogenous Leukemia, Accelerated Phase Chronic Myelogenous Leukemia | Completed | Incyte Biosciences UK | 427 | 2017-12-18 | 2021-08-16 | |
| Metformin+Cytarabine for the Treatment of Relapsed/Refractory AML metformin hydrochloride, cytarabine, laboratory biomarker analysis - Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Phase 1 | Terminated | Northwestern University | 2 | 2015-03-11 | 2019-01-31 |
| Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies cyclophosphamide, fludarabine phosphate, mycophenolate mofetil - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 2 | Withdrawn | University of Medicine and Dentistry of New Jersey | 2014-01-01 | 2016-07-14 | |
| Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies therapeutic allogeneic lymphocytes, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 2 | Completed | University of Chicago | 77 | 2013-04-04 | 2019-08-07 |
| Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Blastic Phase Chronic Myelogenous Leukemia nilotinib, rituximab, cyclophosphamide - B-cell Adult Acute Lymphoblastic Leukemia, Blastic Phase Chronic Myelogenous Leukemia | Phase 2 | Withdrawn | Mayo Clinic | 2012-12-01 | 2015-10-30 | |
| Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant management of therapy complications, musculoskeletal complications management/prevention - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Withdrawn | Roswell Park Cancer Institute | 2012-05-01 | 2012-07-09 | |
| Rasburicase and Allopurinol in Treating Patients With Hematologic Malignancies rasburicase, allopurinol - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 2 | Terminated | Roswell Park Cancer Institute | 24 | 2011-09-29 | 2018-01-09 |
| Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies cyclophosphamide, cyclosporine, peripheral blood stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 43 | 2011-09-01 | 2017-05-19 |
| Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant infection prophylaxis and management, laboratory biomarker analysis, flow cytometry - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Active not recruiting | City of Hope Medical Center | 153 | 2011-01-11 | 2026-10-22 | |
| MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia Akt inhibitor MK2206, diagnostic laboratory biomarker analysis, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Acute Leukemias of Ambiguous Lineage | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2011-01-01 | 2014-04-29 |
| Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer palifermin, flow cytometry, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Completed | Martin, Paul | 6 | 2010-09-01 | 2014-04-02 |
| Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload deferasirox - Iron Overload, Accelerated Phase Chronic Myelogenous Leukemia | Phase 2 | Terminated | City of Hope Medical Center | 1 | 2010-07-01 | 2019-06-18 |
| Plerixafor and Filgrastim For Mobilization of Donor Peripheral Blood Stem Cells Before A Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies plerixafor, filgrastim, peripheral blood stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Terminated | Fred Hutchinson Cancer Center | 1 | 2010-06-01 | 2017-06-28 |
| Entinostat and Sorafenib Tosylate in Treating Patients With Advanced or Metastatic Solid Tumors or Refractory or Relapsed Acute Myeloid Leukemia entinostat, sorafenib tosylate, pharmacological study - Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 44 | 2010-06-01 | 2013-09-19 |
| Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for Cancer massage therapy, questionnaire administration, quality-of-life assessment - Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia | Not applicable | Completed | Wake Forest University Health Sciences | 80 | 2010-04-01 | 2018-07-02 |
| Rituximab in Preventing Acute Graft-Versus-Host Disease in a Donor Stem Cell Transplant for Hematologic Cancer rituximab, mycophenolate mofetil, tacrolimus - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Terminated | University of Nebraska | 20 | 2009-12-10 | 2023-09-06 |
| Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane Hydrochloride in Treating Young Patients With Relapsed or Refractory Solid Tumors, Lymphoma, or Leukemia dexrazoxane hydrochloride, doxorubicin hydrochloride, obatoclax mesylate - Acute Leukemias of Ambiguous Lineage, Acute Undifferentiated Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 22 | 2009-06-01 | 2014-05-01 |
| Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia treosulfan, fludarabine phosphate, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 96 | 2009-02-01 | 2021-06-22 |
| Nilotinib and Imatinib Mesylate After Donor Stem Cell Transplant in Treating Patients With ALL or CML nilotinib, imatinib mesylate, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 40 | 2008-08-14 | 2017-08-10 |
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Blast Crisis (58) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (44) · Leukemia, Myeloid, Acute (42) · Congenital Abnormalities (36) · Leukemia, Myeloid, Accelerated Phase (35) · Leukemia, Lymphocytic, Chronic, B-Cell (25) · Leukemia, Myeloid, Chronic-Phase (25) · Burkitt Lymphoma (23) · Leukemia, Myelomonocytic, Chronic (23) · Lymphoma, Large B-Cell, Diffuse (21) · Lymphoma, B-Cell, Marginal Zone (19) · Lymphoma, Follicular (19) · Lymphoma, Mantle-Cell (19) · Lymphoma, T-Cell, Cutaneous (19) · Mycosis Fungoides (19)
Bone Marrow Diseases (58) · Carcinogenesis (58) · Cell Transformation, Neoplastic (58) · Chronic Disease (58) · Disease Attributes (58) · Hematologic Diseases (58) · Hemic and Lymphatic Diseases (58) · Leukemia, Myeloid (58) · Neoplasms (58) · Neoplasms by Histologic Type (58) · Neoplastic Processes (58) · Pathologic Processes (58) · Pathological Conditions, Signs and Symptoms (58) · Leukemia (57) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (48)
Peripheral Blood Stem Cell Transplantation (8) · fludarabine phosphate (8) · Cytarabine (7) · Tacrolimus (6) · Whole-Body Irradiation (6) · Busulfan (5) · Cyclophosphamide (5) · Imatinib Mesylate (5) · Mycophenolic Acid (5) · Flow Cytometry (4) · Methotrexate (4) · Therapeutics (4) · Vorinostat (4) · merphos (4) · Antilymphocyte Serum (3)
National Cancer Institute (NCI) (30) · Fred Hutchinson Cancer Center (11) · City of Hope Medical Center (3) · Children's Oncology Group (2) · Roswell Park Cancer Institute (2) · Case Comprehensive Cancer Center (1) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (1) · Incyte Biosciences UK (1) · Martin, Paul (1) · Mayo Clinic (1) · Northwestern University (1) · University of Chicago (1) · University of Medicine and Dentistry of New Jersey (1) · University of Nebraska (1) · Wake Forest University Health Sciences (1)
United States (55) · Canada (3) · Italy (2) · United Kingdom (2) · France (1) · Germany (1) · Ireland (1) · Netherlands (1) · Spain (1) · Switzerland (1)
Francis Giles (3) · Jorge Cortes (3) · Paul Martin (3) · Maryam Fouladi (2) · Richard Aplenc (2) · Alex Adjei (1) · Ann Woolfrey (1) · Anthony Stein (1) · Aref Al-Kali, M.D. (1) · B. Smith (1) · Boglarka Gyurkocza (1) · Brenda Cooper (1) · Brenda Cooper, MD (1) · David Maloney (1) · Douglas Ross (1)
PMID 18698002, PMID 20460644, PMID 21791475, PMID 23393050, PMID 23443507, PMID 24362550, PMID 26764356, PMID 28817727, PMID 32499241, PMID 32628342, PMID 33420905, PMID 36282798, PMID 38033284
P30CA015704 (5), U01CA062461 (5), U01CA097452 (4), N01CM62202 (3), P01CA018029 (3), U01CA062505 (3), P01HL036444 (2), U01CA062502 (2), U01CA070095 (2), 2015 (1), 2023 (1), N01CM17003 (1), P01CA015396 (1), P01CA078902 (1), P30CA006973 (1)