22 completed. 22 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 22 | Completed 22 |
| Phase 2 | 2 | Completed 2 |
Follow Blast Crisis: new trials by email Literature Review of Blast Crisis trials Research Report on Blast Crisis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Eltrombopag Olamine in Treating Thrombocytopenia in Patients With Chronic Myeloid Leukemia or Myelofibrosis Receiving Tyrosine Kinase Therapy Eltrombopag Olamine - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Phase 2 / Phase 3 | Completed | M.D. Anderson Cancer Center | 21 | 2012-01-13 | 2023-09-26 |
| American Ginseng in Treating Patients With Fatigue Caused by Cancer American ginseng, placebo - Chronic Myeloproliferative Disorders, Fatigue | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 364 | 2008-10-01 | 2017-02-09 |
| Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder cyclosporine ophthalmic emulsion, placebo - Chronic Myeloproliferative Disorders, Graft Versus Host Disease | Phase 3 | Completed | Vanderbilt-Ingram Cancer Center | 164 | 2008-10-01 | 2017-03-07 |
| Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications internet-based intervention, questionnaire administration, psychosocial assessment and care - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 3 | Completed | Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium | 1337 | 2008-08-01 | 2012-03-07 |
| A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families educational intervention, informational intervention, internet-based intervention - Chronic Myeloproliferative Disorders, Leukemia | Phase 3 | Completed | Tufts Medical Center | 198 | 2008-06-01 | 2011-07-13 |
| Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial educational intervention - Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders | Phase 3 | Completed | Case Comprehensive Cancer Center | 583 | 2008-04-01 | 2020-07-27 |
| Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Fentanyl sublingual spray, Placebo - Cancer | Phase 3 | Completed | INSYS Therapeutics Inc | 130 | 2007-10-01 | 2014-03-05 |
| Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain educational intervention, Titrated pain management, questionnaire administration - Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders | Phase 3 | Completed | Vanderbilt-Ingram Cancer Center | 98 | 2005-05-01 | 2012-09-06 |
| Laboratory-Treated Donor Bone Marrow in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer graft versus host disease prophylaxis/therapy, allogeneic bone marrow transplantation, in vitro-treated bone marrow transplantation - Graft Versus Host Disease, Leukemia | Phase 3 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 72 | 2002-12-01 | 2014-04-17 |
| Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation acyclovir, acyclovir sodium, valacyclovir - Cancer | Phase 3 | Completed | Fred Hutchinson Cancer Center | 2002-04-01 | 2010-09-21 | |
| Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment ondansetron, placebo - Chronic Myeloproliferative Disorders, Leukemia | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 100 | 2000-10-01 | 2016-07-06 |
| Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment caspofungin acetate, liposomal amphotericin B - Cancer | Phase 3 | Completed | Memorial Sloan Kettering Cancer Center | 2000-08-01 | 2013-01-18 | |
| Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Fragmin, placebo - Cervical Cancer, Chronic Myeloproliferative Disorders | Phase 3 | Completed | Jonsson Comprehensive Cancer Center | 2000-04-01 | 2020-08-03 | |
| St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer St. John's wort - Chronic Myeloproliferative Disorders, Fatigue | Phase 3 | Completed | Memorial Sloan Kettering Cancer Center | 1999-12-01 | 2013-01-18 | |
| Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation captopril, cyclophosphamide, autologous bone marrow transplantation - Cancer | Phase 3 | Completed | Northwestern University | 35 | 1999-10-01 | 2012-06-06 |
| Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients liposomal amphotericin B - Cancer | Phase 3 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 115 | 1999-06-01 | 2012-09-24 |
| Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation palivizumab, ribavirin - Cancer | Phase 3 | Completed | Fred Hutchinson Cancer Center | 1999-02-01 | 2010-04-02 | |
| Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer anti-thymocyte globulin, busulfan, carboplatin - Chronic Myeloproliferative Disorders, Leukemia | Phase 2 / Phase 3 | Completed | Roswell Park Cancer Institute | 361 | 1998-10-19 | 2021-08-13 |
| Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation fluconazole, itraconazole - Cancer | Phase 3 | Completed | Fred Hutchinson Cancer Center | 578 | 1998-10-01 | 2010-04-02 |
| Treatment for Chronic Pain in Patients With Advanced Cancer dextromethorphan hydrobromide, morphine sulfate - Chronic Myeloproliferative Disorders, Leukemia | Phase 3 | Completed | NCIC Clinical Trials Group | 87 | 1998-06-11 | 2020-04-03 |
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Leukemia, Myeloid, Accelerated Phase (21) · Leukemia, Myeloid, Chronic-Phase (21) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (21) · Burkitt Lymphoma (20) · Leukemia, Lymphocytic, Chronic, B-Cell (19) · Lymphoma, B-Cell, Marginal Zone (19) · Lymphoma, Follicular (19) · Lymphoma, Large B-Cell, Diffuse (19) · Lymphoma, Large-Cell, Immunoblastic (19) · Lymphoma, Mantle-Cell (19) · Lymphoma, Non-Hodgkin (19) · Primary Myelofibrosis (19) · Hodgkin Disease (18) · Leukemia, Myeloid, Acute (18)
Bone Marrow Diseases (22) · Carcinogenesis (22) · Cell Transformation, Neoplastic (22) · Chronic Disease (22) · Disease Attributes (22) · Hematologic Diseases (22) · Hemic and Lymphatic Diseases (22) · Leukemia, Myeloid (22) · Neoplasms by Histologic Type (22) · Neoplastic Processes (22) · Pathologic Processes (22) · Pathological Conditions, Signs and Symptoms (22) · Immune System Diseases (21) · Immunoproliferative Disorders (21) · Leukemia, Lymphoid (21)
Cyclophosphamide (3) · Early Intervention, Educational (3) · Etoposide (2) · Psychiatric Rehabilitation (2) · Radiotherapy (2) · Therapeutics (2) · liposomal amphotericin B (2) · Acyclovir (1) · Antilymphocyte Serum (1) · Asian ginseng (1) · Busulfan (1) · Captopril (1) · Carboplatin (1) · Carmustine (1) · Caspofungin (1)
Fred Hutchinson Cancer Center (3) · Memorial Sloan Kettering Cancer Center (3) · Alliance for Clinical Trials in Oncology (2) · European Organisation for Research and Treatment of Cancer - EORTC (2) · Vanderbilt-Ingram Cancer Center (2) · Case Comprehensive Cancer Center (1) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (1) · INSYS Therapeutics Inc (1) · Jonsson Comprehensive Cancer Center (1) · M.D. Anderson Cancer Center (1) · NCIC Clinical Trials Group (1) · Northwestern University (1) · Roswell Park Cancer Institute (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · Tufts Medical Center (1)
United States (20) · Belgium (2) · Canada (2) · Czechia (2) · France (2) · Germany (2) · Greece (2) · Israel (2) · Slovakia (2) · Turkey (Türkiye) (2) · Finland (1) · Hungary (1) · Italy (1) · Netherlands (1) · Portugal (1)
David J. Straus, MD (1) · Debra Barton, RN, PhD, AOCN, FAAN (1) · Eduardo Bruera, MD (1) · Garrett Nichols, MD, MSC (1) · Gautam Borthakur (1) · John A. Glaspy, MD, MPH (1) · Karen Syrjala (1) · Kent Sepkowitz, MD (1) · Kieren A. Marr, MD (1) · Larry Dillaha, MD (1) · Leo I. Gordon, MD (1) · Madan Jagasia, MD (1) · Michael Boeckh, MD (1) · Michel P. Glauser, MD (1) · Nancy Wells, DNSc, RN (1)
PMID 15459300, PMID 17397698, PMID 22157574, PMID 22480131, PMID 26700120, PMID 26700123, PMID 27020837, PMID 32628342, PMID 33420905, PMID 36282798, PMID 36999619
P30CA068485 (2), P01CA015396 (1), P30CA006973 (1), P30CA008748 (1), R01CA112631 (1), R01CA119196 (1), R01CA127655 (1)