20 completed, 16 recruiting, 8 terminated, 8 unknown. 24 Not applicable, 16 Phase 2, 6 Phase 1, 5 Phase 4, 4 Phase 3.
Follow Bladder Pain Syndrome: new trials by email Literature Review of Bladder Pain Syndrome trials Research Report on Bladder Pain Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Pregabalin Combined With Educational and Behavioral Intervention for Bladder Pain Syndrome/Interstitial Cystitis Educational and Behavioral Management Program (EBMP), Pregabalin - Bladder Pain Syndrome, Pregabalin | Phase 1 | Not yet recruiting | Beijing Tiantan Hospital | 200 | 2026-12-31 | 2026-08-07 |
| Venlafaxine Combined With Education and Behavioral Intervention for Bladder Pain Syndrome Venlafaxine oral tablet combined with Education and Behavioral Modification Program (EBMP), Education and Behavioral Modification Program (EBMP) only - Bladder Pain Syndrome, Chronic Pelvic Nociplastic Pain | Phase 1 | Not yet recruiting | Beijing Tiantan Hospital | 140 | 2026-12-31 | 2026-07-13 |
| Mirogabalin Plus EBMP for IC/BPS Behavioral: Educational and Behavioral Management Program (EBMP), Intervention - Bladder Pain Syndrome, Educational Behavioral Intervention | Phase 1 | Not yet recruiting | Beijing Tiantan Hospital | 200 | 2026-09-20 | 2026-09-03 |
| Efficacy of Pulsed Electromagnetic Field and Heparin/Bupivacaine Instillations Pulsed Electromagnetic Field (PEMF) Device, Sham Pulsed Electromagnetic Feild (PEMF) Device - Interstitial Cystitis, Chronic Interstitial Cystitis | Not applicable | Withdrawn | Wake Forest University Health Sciences | 2026-05-01 | 2026-07-15 | |
| Aerobic Exercise and Connective Tissue Massage in Painful Bladder Syndrome Patient Education, Aerobic Exercise Training, Connective Tissue Massage - Bladder Pain Syndrome, Painful Bladder Syndrome | Not applicable | Recruiting | Hacettepe University | 36 | 2026-04-30 | 2026-09-24 |
| Intravesical Ozone Therapy for Interstitial Cystitis/Bladder Pain Syndrome Intravesical Ozone Therapy, Placebo (Normal Saline), Control - Interstitial Cystitis, Bladder Pain Syndrome | Not applicable | Not yet recruiting | Medipol University | 60 | 2025-06-01 | 2025-04-27 |
| Safety and Efficacy of Aloe Vera in the Management of the Symptoms of Interstitial Cystitis Desert Harvest Aloe Vera Capsules, Placebo Capsules - Interstitial Cystitis, Chronic Interstitial Cystitis | Early Phase 1 | Recruiting | Wake Forest University Health Sciences | 30 | 2025-02-18 | 2026-07-28 |
| Acupuncture First for IC/BPS Acupuncture, Behavioral management, Physical therapy - Bladder Pain Syndrome, Interstitial Cystitis | Not applicable | Recruiting | University Hospitals Cleveland Medical Center | 34 | 2025-01-21 | 2026-01-08 |
| Safety, Efficacy, and Frequency of Administration of VNX001 in the Treatment of Interstitial Cystitis / Bladder Pain Syndrome (IC/BPS) VNX001 - Interstitial Cystitis, Bladder Pain Syndrome | Phase 2 | Recruiting | Vaneltix Pharma, Inc. | 50 | 2024-12-13 | 2026-01-22 |
| Effect of Intradetrusor onabotulinumtoxinA Injection Versus Conservative Management on Female Sexual Function in Patients With Bladder Pain Syndrome Onabotulinum toxin A, Conservative management (dietary and behavioral) - Bladder Pain Syndrome, Female Sexual Dysfunction | Recruiting | Walter Reed National Military Medical Center | 159 | 2024-11-01 | 2024-12-11 | |
| Evaluating the Efficacy and Patient Experience of Catheter-Free Intravesical Instillation Catheter-Free Intravesical Instillation with a special syringe adapter - Interstitial Cystitis, Recurrent Cystitis | Recruiting | Jahn Ferenc South Pest Teaching Hospital | 300 | 2024-10-01 | 2024-12-12 | |
| Auricular Acupressure Therapy for Patients With IC/BPS Auricular Acupressure - Interstitial Cystitis, Bladder Pain Syndrome | Not applicable | Withdrawn | Wake Forest University Health Sciences | 2024-07-01 | 2024-07-30 | |
| Pain Type and Interstitial Cystitis/Bladder Pain Syndrome Treatment Psychosocial Treatment, Pelvic Floor Physical Therapy - Chronic Interstitial Cystitis, Bladder Pain Syndrome | Not applicable | Recruiting | Vanderbilt University Medical Center | 220 | 2024-05-01 | 2026-01-21 |
| Migraine Medication Effects on Urinary Symptoms Ubrogepant, Rimegepant, Atogepant - Overactive Bladder, Bladder Pain Syndrome | Enrolling by invitation | The Cleveland Clinic | 200 | 2024-04-05 | 2026-10-19 | |
| Bladder Botox UTI Antibiotic Prophylaxis Nitrofurantoin 100 MG - Overactive Bladder, Bladder Pain Syndrome | Phase 4 | Recruiting | Walter Reed National Military Medical Center | 100 | 2024-04-04 | 2025-02-19 |
| fMRI for BPS: A Descriptive Study of Findings and Symptoms fMRI - Bladder Pain Syndrome | Recruiting | RenJi Hospital | 120 | 2024-03-01 | 2024-03-06 | |
| Investigation of the Effectiveness of Acupuncture in Patients Diagnosed With Interstitial Cystitis ACUPUNCTURE - Interstitial Cystitis, Bladder Pain Syndrome | Not applicable | Completed | Medipol University | 26 | 2024-01-01 | 2026-06-30 |
| New Approaches to Nerve Stimulation Therapy for Bladder Pain Syndrome Pulsed radiofrequency ablation - Bladder Pain Syndrome | Not applicable | Recruiting | Walter Reed National Military Medical Center | 5 | 2024-01-01 | 2026-04-30 |
| The Study is Being Conducted to Find a New Treatment for Patients Suffering From Interstitial Cystitis With Hunner's Lesions Neovasculgen®, Placebo - IC, Hunner Type Interstitial Cystitis | Phase 2 / Phase 3 | Recruiting | JSC NextGen | 180 | 2023-12-29 | 2026-03-10 |
| Safety and Efficacy Study of VNX001 Compared to Its Individual Components (Lidocaine and Heparin) or Placebo in Subjects With IC/BPS VNX001, Placebo, Lidocaine - Interstitial Cystitis, Bladder Pain Syndrome | Phase 2 | Recruiting | Vaneltix Pharma, Inc. | 120 | 2023-05-22 | 2026-01-22 |
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Cystitis, Interstitial (65) · Chronic Pain (5) · Pelvic Pain (5) · Urinary Bladder, Overactive (4) · Prostatitis (3) · Urinary Incontinence (3) · Bronchiolitis Obliterans Syndrome (2) · Nocturia (2) · Pain (2) · Urinary Tract Infections (2) · Communicable Diseases (1) · Cystitis (1) · Cystitis, Hemorrhagic (1) · Endometriosis (1) · Fecal Incontinence (1)
Female Urogenital Diseases (65) · Female Urogenital Diseases and Pregnancy Complications (65) · Male Urogenital Diseases (65) · Urogenital Diseases (65) · Cystitis (64) · Urinary Bladder Diseases (64) · Urologic Diseases (64) · Pathological Conditions, Signs and Symptoms (20) · Signs and Symptoms (18) · Neurologic Manifestations (11) · Pain (9) · Lower Urinary Tract Symptoms (7) · Urological Manifestations (7) · Genital Diseases (4) · Genital Diseases, Male (3)
Heparin (4) · Botulinum Toxins, Type A (3) · 4-(4-(aminomethyl)-7a-methyl-1-methylideneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexan-1-ol (2) · Acupuncture Therapy (2) · Administration, Intravesical (2) · Amitriptyline (2) · Lidocaine (2) · Naltrexone (2) · Patient Education as Topic (2) · Therapeutics (2) · Transcutaneous Electric Nerve Stimulation (2) · onabotulinum toxin A (2) · Biofeedback, Psychology (1) · Biopsy (1) · Cellulose (1)
Wake Forest University Health Sciences (6) · Walter Reed National Military Medical Center (5) · Beijing Tiantan Hospital (3) · Aquinox Pharmaceuticals (Canada) Inc. (2) · Hacettepe University (2) · Medipol University (2) · Samsung Medical Center (2) · Stanford University (2) · State University of New York at Buffalo (2) · University of Pennsylvania (2) · Urigen (2) · Vanderbilt University Medical Center (2) · Vaneltix Pharma, Inc. (2) · Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (1) · Anhembi Morumbi University (1)
United States (36) · Turkey (Türkiye) (4) · Hungary (3) · Netherlands (3) · South Korea (3) · United Kingdom (3) · Belgium (2) · Brazil (2) · Canada (2) · China (2) · Czechia (2) · Latvia (2) · Poland (2) · Russia (2) · Spain (2)
Stephen J Walker, PhD (3) · Stephen Walker, PhD (3) · Ahmed El Hefnawy, Msc, MD (1) · Amy D. Dobberfuhl, M.D. (1) · Ariana Smith, MD (1) · Arthur L Burnett, MD, FACS (1) · C. Lowell Parsons, MD (1) · Catherine Brownstein, Ph.D. (1) · Clarice Tanaka, PhD (1) · Claudia Meissner, MD (1) · Craig V Comiter, MD (1) · David Sheyn, MD (1) · Eli Medvescek, MD (1)
PMID 32734597, PMID 12050508, PMID 15201781, PMID 15856132, PMID 16979286, PMID 19400928, PMID 21600549, PMID 23670165, PMID 25596361, PMID 26384156, PMID 27378135, PMID 27790294, PMID 29331031, PMID 29777618, PMID 31099215, PMID 33831942, PMID 35704106, PMID 35860417, PMID 35964133, PMID 36910591, PMID 37045569, PMID 38768800, PMID 39261949, PMID 40473282, PMID 41705870, PMID 42604487, PMID 9083302, PMID 9146003
2016 (1), K23DK118118 (1), R01DK128233 (1), R01DK133415 (1)