6 completed, 2 active not recruiting, 2 recruiting, 1 terminated. 3 Not applicable, 3 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Completed 2, Active not recruiting 1 |
| Phase 4 | 3 | Active not recruiting 1, Unknown 1, Withdrawn 1 |
Follow Birth Defect: new trials by email Literature Review of Birth Defect trials Research Report on Birth Defect
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| B-vitamin Levels and Adverse Pregnancy Outcomes No intervention - Birth Defect, Pregnancy Loss | Completed | Westlake University | 7500 | 2020-12-01 | 2023-06-01 | |
| The Heartland Study Pregnancy Related, Pregnancy Complications | Recruiting | Heartland Health Research Alliance | 2600 | 2020-01-11 | 2025-06-29 | |
| The Pilot Study of High-throughput Sequencing in Neonatal Birth Defects NGS panel - Birth Defect, Newborn; Fit | Completed | Children's Hospital of Chongqing Medical University | 3423 | 2019-10-01 | 2022-04-12 | |
| Use of Videos to Improve Patient Knowledge on Prenatal Genetics video - Aneuploidy, Birth Defect | Not applicable | Completed | University of South Florida | 106 | 2019-05-30 | 2020-05-19 |
| Evaluation of Trigeminal Nerve Blockade Ropivacaine, Sham Comparator - Mouth Abnormalities, Cleft Palate | Phase 4 | Active not recruiting | University of Florida | 40 | 2018-11-20 | 2026-07-21 |
| Hydrops: Diagnosing & Redefining Outcomes With Precision Study Exome sequencing - Hydrops Fetalis, Birth Defect | Not applicable | Active not recruiting | University of California, San Francisco | 500 | 2018-10-11 | 2026-04-17 |
| The Use of Gastrografin to Help Alleviate Bowel Obstruction in Gastroschisis Patients. Gastrografin - Gastroschisis, Bowel Obstruction | Phase 4 | Withdrawn | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2018-08-03 | 2023-11-01 | |
| Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise Fetal Magnetocardiogram and Neonatal Electrocardiogram, Substudy only: Maternal/Infant Pharmacogenomic assessment postnatally - High Risk Pregnancy, Congenital Heart Disease | Recruiting | Medical College of Wisconsin | 30 | 2018-07-01 | 2026-03-04 | |
| Tenofovir Disoproxil Fumarate in Combination of Hepatitis B Vaccine for Preventing Hepatitis B Vertical Transmission Tenofovir Disoproxil Fumarate (TDF) 300 mg oral daily. - Hepatitis B Infection, Congenital Malformation | Phase 4 | Unknown | New Discovery LLC | 280 | 2018-06-10 | 2019-12-12 |
| Afluria Pregnancy Registry Afluria Influenza Vaccine - Influenza, Human, Pregnancy | Completed | Seqirus | 490 | 2017-09-08 | 2022-02-09 | |
| Flucelvax (TIVc or QIVc) Pregnancy Registry Flucelvax Trivalent Influenza Vaccine, Flucelvax Quadrivalent Influenza Vaccine - Influenza, Human, Pregnancy | Completed | Seqirus | 692 | 2017-09-01 | 2022-11-04 | |
| Clinical Utility of Pediatric Whole Exome Sequencing Whole Exome Sequencing - Encephalopathy, Birth Defect | Not applicable | Completed | University of California, San Francisco | 529 | 2017-08-01 | 2023-07-18 |
| Nplate® Pregnancy Exposure Registry Not applicable- observational study - Birth Defect, Spontaneous Abortions | Terminated | Amgen | 4 | 2009-05-01 | 2015-01-06 |
Congenital Abnormalities (13) · Abortion, Spontaneous (2) · Gastroschisis (2) · Hydrops Fetalis (2) · Influenza, Human (2) · Pregnancy Complications (2) · Abnormalities, Multiple (1) · Aneuploidy (1) · Brain Diseases (1) · Brugada Syndrome (1) · Cerebral Palsy (1) · Cleft Palate (1) · Diabetes, Gestational (1) · Epilepsy (1) · Fetal Death (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (13) · Pathological Conditions, Signs and Symptoms (6) · Female Urogenital Diseases and Pregnancy Complications (5) · Urogenital Diseases (5) · Infections (3) · Musculoskeletal Abnormalities (3) · Musculoskeletal Diseases (3) · Pathologic Processes (3) · Pregnancy Complications (3) · Signs and Symptoms (3) · Virus Diseases (3) · Cardiovascular Diseases (2) · Digestive System Diseases (2) · Edema (2) · Erythroblastosis, Fetal (2)
Exome (2) · Afluria (1) · Diatrizoate (1) · Diatrizoate Meglumine (1) · Influenza Vaccines (1) · Ropivacaine (1) · Tenofovir (1) · Videotape Recording (1) · hepatitis B hyperimmune globulin (1)
Seqirus (2) · University of California, San Francisco (2) · Amgen (1) · Children's Hospital of Chongqing Medical University (1) · Heartland Health Research Alliance (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Medical College of Wisconsin (1) · New Discovery LLC (1) · University of Florida (1) · University of South Florida (1) · Westlake University (1)
United States (8) · China (3) · Canada (1)
Mary Norton, MD (2) · Barbara Koenig, PhD (1) · Calvin Q Pan, MD (1) · Cameron R Smith, MD, PhD (1) · Erhei Dai, MD (1) · Hongjun Shi, PhD (1) · Janette F Strasburger, MD (1) · Karla Leavitt, MD, MPH (1) · Lin Zou, Ph.D (1) · Pui-Yan Kwok, MD/PhD (1) · Teresa Sparks, MD, MAS (1)
PMID 33027564, PMID 35396980, PMID 37993831, PMID 39540799
K12HD001262 (1), R01HL143485 (1), U01HG009599 (1)