4 active not recruiting. 4 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Active not recruiting 4 |
| Phase 2 | 1 | Active not recruiting 1 |
Follow Bipolar Disorder: new trials by email Literature Review of Bipolar Disorder trials Research Report on Bipolar Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Open-label Study of Azetukalner in Bipolar I or II Depression (X-CEED-OLE) Azetukalner - Bipolar Depression, Bipolar I Disorder | Phase 3 | Active not recruiting | Xenon Pharmaceuticals Inc. | 400 | 2025-10-30 | 2026-10-13 |
| A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression) Azetukalner, Placebo - Bipolar Disorder, Bipolar Depression | Phase 3 | Active not recruiting | Xenon Pharmaceuticals Inc. | 400 | 2025-08-08 | 2026-10-13 |
| Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy Sigma-Stim, RUL LAP-ST (Low-Amplitude Pulse Seizure Therapy - Right Unilateral) - Suicidal Ideation, Major Depressive Disorder | Phase 2 / Phase 3 | Active not recruiting | Michigan State University | 30 | 2024-07-03 | 2026-11-02 |
| Predictors of Intravenous Ketamine Response in TRD Ketamine, Midazolam - Treatment Resistant Depression, Major Depressive Disorder | Phase 3 | Active not recruiting | Abraham Nunes | 40 | 2024-01-19 | 2026-05-22 |
Depressive Disorder, Major (2) · Depression (1) · Depressive Disorder, Treatment-Resistant (1) · Psychotic Disorders (1) · Suicidal Ideation (1) · Suicide (1)
Bipolar and Related Disorders (4) · Mental Disorders (4) · Mood Disorders (4) · Depressive Disorder (2) · Behavior (1) · Behavioral Symptoms (1) · Schizophrenia Spectrum and Other Psychotic Disorders (1) · Self-Injurious Behavior (1)
Ketamine (1) · Midazolam (1) · XEN1101 (1)
Xenon Pharmaceuticals Inc. (2) · Abraham Nunes (1) · Michigan State University (1)
United States (3) · Bulgaria (1) · Canada (1) · Germany (1) · Spain (1)
Abraham Nunes, MD PhD MBA FRCPC (1) · Nagy A Youssef, MD, PhD (1)