11 completed, 5 unknown, 1 not yet recruiting, 1 terminated. 9 Not applicable, 4 Phase 2, 2 Phase 3, 1 Early Phase 1, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 6, Unknown 2, Not yet recruiting 1 |
| Phase 2 | 4 | Unknown 2, Completed 1, Terminated 1 |
| Phase 3 | 2 | Unknown 2 |
| Early Phase 1 | 1 | Withdrawn 1 |
| Phase 1 | 1 | Unknown 1 |
Follow Beta Thalassemia Major: new trials by email Literature Review of Beta Thalassemia Major trials Research Report on Beta Thalassemia Major
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of Laughter Yoga in Beta Thalassaemia Major Patients: a Randomised Controlled Trial laughter yoga - Beta Thalassemia Major, Thalassemia Majors (Beta-Thalassemia Major) | Not applicable | Not yet recruiting | Ataturk University | 60 | 2025-06-01 | 2025-05-20 |
| Iron Accumulation in Erythrocytes in Patients Beta Thalassemia Major | Completed | Ankara City Hospital Bilkent | 100 | 2024-10-20 | 2026-03-20 | |
| Elastography vs Iron Regulators in the Diagnosis of Hepatic Fibrosis- Iron Overload in Children With Beta- Thalassemia Serum ferritin, Serum hepcidin - Liver Fibrosis, Beta Thalassemia Major | Completed | Tanta University | 100 | 2024-09-12 | 2025-09-04 | |
| Inspiratory Muscle Training in Children With Beta Thalasemia inspiratory muscle training - Beta Thalassemia Major | Not applicable | Unknown | Ahram Canadian University | 40 | 2024-06-06 | 2024-06-20 |
| Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe Hemoglobinopathies Bortezomib, Busulfan, Cyclophosphamide - Beta Thalassemia Major, Sickle Beta 0 Thalassemia | Early Phase 1 | Withdrawn | M.D. Anderson Cancer Center | 2020-12-29 | 2024-10-24 | |
| ERN-EuroBloodNet Registry on Patients With Rare Red Blood Cell Defects and COVID-19 Non applicable, is a patient registry - Hemoglobinopathies, Sickle Cell Disease | Completed | Hospital Universitari Vall d'Hebron Research Institute | 684 | 2020-04-15 | 2025-02-18 | |
| Phase 2a Pilot Study of NBMI Treatment in Patients With Beta Thalassemia Major, Requiring Iron Chelation Emeramide - Beta Thalassemia Major | Phase 2 | Completed | EmeraMed | 13 | 2019-11-21 | 2021-08-26 |
| PK of SOF/LED in HCV - Infected Adolescents With Haematological Disorders Sofosbuvir and Ledipasvir - HCV Infection, Beta Thalassemia Major | Phase 3 | Unknown | Ain Shams University | 24 | 2018-06-11 | 2023-03-06 |
| Gene Therapy for Beta-Thalassemia Major Using Autologous Hematopoietic Stem Cell Genetically Modified Autologous CD34+ cells genetically modified - Beta Thalassemia Major | Phase 1 / Phase 2 | Unknown | Nanfang Hospital, Southern Medical University | 10 | 2017-09-15 | 2017-09-08 |
| Monitoring of Chimerism After Transplantation in Patients With β Thalassemia Major and the Treatment Strategies for the Reduction of Chimerism Interleukin-2, Donor Regulatory T-Lymphocytes - Beta Thalassemia Major | Not applicable | Unknown | First Affiliated Hospital of Guangxi Medical University | 30 | 2016-08-01 | 2018-08-28 |
| Effect of Spirulina on Liver Fibrosis by Transient Elastography in Beta Thalassemic Children With Hepatitis C Spirulina - Beta Thalassemia Major | Not applicable | Completed | Tanta University | 60 | 2015-12-01 | 2018-09-11 |
| Effect of Spirulina on Serum Hyaluronic Acid in Beta Thalassemic Children With Hepatitis C Spirulina - Beta Thalassemia Major | Not applicable | Completed | Tanta University | 60 | 2015-12-01 | 2019-04-10 |
| the Potential Immunomodulatory Effects of Spirulina on Thalassemic Children Spirulina - Beta Thalassemia Major | Not applicable | Completed | Tanta University | 60 | 2015-10-01 | 2017-10-25 |
| Effect of Spirulina Compared to Amlodipine on Cardiac Iron Overload in Children With Beta Thalassemia Spirulina, Amlodipine - Beta Thalassemia Major | Not applicable | Completed | Tanta University | 40 | 2015-04-01 | 2018-07-12 |
| Effect of Spirulina on Liver Iron Concentration in Beta Thalassemic Children With Hepatitis C spirulina - Beta Thalassemia Major | Not applicable | Completed | Tanta University | 30 | 2015-03-01 | 2018-09-11 |
| An Algorithm to Start Iron Chelation in Minimally Transfused Young Beta-thalassemia Major Patients Deferiprone - Beta Thalassemia Major | Phase 2 / Phase 3 | Unknown | Ain Shams University | 64 | 2014-07-01 | 2015-01-14 |
| Anthropometric Measurements in Children Having Transfusion-dependent Beta Thalassemia serum ferritin and hemoglobin test - Beta Thalassemia Major | Completed | Aga Khan University | 367 | 2013-01-01 | 2019-05-13 | |
| Study to Determine the Safety and Tolerability of Sotatercept (ACE-011) in Adults With Beta( β)- Thalassemia. SOTATERCEPT (ACE-011) - Beta Thalassemia Major, Beta Thalassemia Intermedia | Phase 2 | Terminated | Celgene | 46 | 2012-10-10 | 2023-06-18 |
| Assess the Feasibility and Safety of Granulocyte Colony Stimulating Factor (GCSF) Mobilization of CD34+ Hematopoietic Progenitor Cells in Patients With Betathalassemia Major GCSF, Central venous line placement, Stem cell Collection (leukapheresis) - Beta Thalassemia Major, Congenital Anemias | Not applicable | Completed | Memorial Sloan Kettering Cancer Center | 5 | 2008-04-01 | 2016-11-25 |
beta-Thalassemia (19) · Anemia, Sickle Cell (2) · Iron Overload (2) · Anemia (1) · Beta Thalassemia, Dominant Inclusion Body Type (1) · COVID-19 (1) · Delta-Beta Thalassemia (1) · Elliptocytosis, Hereditary (1) · Fatigue (1) · Hemoglobin SC Disease (1) · Hemoglobinopathies (1) · Hepatitis C (1) · Liver Cirrhosis (1) · Sleep Initiation and Maintenance Disorders (1) · Spherocytosis, Hereditary (1)
Anemia, Hemolytic (19) · Anemia, Hemolytic, Congenital (19) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (19) · Genetic Diseases, Inborn (19) · Hematologic Diseases (19) · Hemic and Lymphatic Diseases (19) · Anemia (18) · Hemoglobinopathies (18) · Thalassemia (18) · Digestive System Diseases (2) · Infections (2) · Iron Metabolism Disorders (2) · Liver Diseases (2) · Metabolic Diseases (2) · Nutritional and Metabolic Diseases (2)
ACE-011 (1) · Amlodipine (1) · Antilymphocyte Serum (1) · Bortezomib (1) · Busulfan (1) · CT-P10 (1) · Calcium Dobesilate (1) · Cyclophosphamide (1) · Deferiprone (1) · Dexamethasone (1) · Hematopoietic Stem Cell Transplantation (1) · Interleukin-2 (1) · Laughter Therapy (1) · Leukapheresis (1) · Mycophenolic Acid (1)
Tanta University (6) · Ain Shams University (2) · Aga Khan University (1) · Ahram Canadian University (1) · Ankara City Hospital Bilkent (1) · Ataturk University (1) · Celgene (1) · EmeraMed (1) · First Affiliated Hospital of Guangxi Medical University (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · M.D. Anderson Cancer Center (1) · Memorial Sloan Kettering Cancer Center (1) · Nanfang Hospital, Southern Medical University (1)
Egypt (9) · China (2) · Turkey (Türkiye) (2) · Albania (1) · France (1) · Greece (1) · Italy (1) · Spain (1) · United Kingdom (1) · United States (1)
Farid Boulad, MD (1) · Kris M Mahadeo (1) · Manal H El-Sayed, M.D (1) · Mohamed R El-Shanshory, MD (1) · Mohsen S Elalfy, professour (1) · Sahar M El-Haggar, MD (1)