127 completed, 19 unknown, 16 terminated, 8 recruiting. 46 Phase 2, 29 Not applicable, 21 Phase 3, 19 Phase 4, 11 Phase 1.
Follow Iron Overload: new trials by email Literature Review of Iron Overload trials Research Report on Iron Overload
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Native T1 Mapping and ECV in Chronic Hemolytic Anemia Hemolytic Anemia, Thalassemia | Not yet recruiting | Assiut University | 54 | 2026-10-20 | 2026-10-20 | |
| A Study to Evaluate BBI-001 in Healthy Volunteers and in Patients With Hereditary Hemochromatosis BBI-001, Placebo - Hereditary Hemochromatosis | Phase 1 / Phase 2 | Recruiting | Bond Biosciences | 34 | 2026-05-04 | 2026-05-13 |
| Evaluation of the Quality of Life in Patients With Chronic Iron Overload Due to Hemoglobinopathies in Greece. Thalassemia, Iron Overload | Not yet recruiting | Elpen Pharmaceutical Co. Inc. | 150 | 2026-04-15 | 2026-01-20 | |
| Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis Vamifeport, Placebo - Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis | Phase 2 | Active not recruiting | CSL Behring | 84 | 2026-01-22 | 2026-10-21 |
| Early Screening and Treatment of Heart Complication in Sickle Cell Disease Deferoxamine, Deferasirox, Deferiprone - Sickle Cell Disease | Phase 2 | Recruiting | Inova Health Care Services | 100 | 2025-10-07 | 2026-09-09 |
| Impact of Iron Overload on the Incidence of Liver Complications in Long-Term Survivors (≥10 Years) of Allogeneic Hematopoietic Stem-Cell Transplantation. Cohort - Iron Overload, Hemosiderosis | Recruiting | Assistance Publique - Hôpitaux de Paris | 500 | 2025-08-20 | 2026-04-27 | |
| Pharmacokinetics and Pharmacodynamics of Two Prolonged-release Formulations of Vamifeport in Healthy Adults Vamifeport IRF, Vamifeport PR1, Vamifeport PR2 - Healthy Volunteers | Phase 1 | Completed | CSL Behring | 22 | 2024-11-22 | 2025-06-27 |
| Iron Accumulation in Erythrocytes in Patients Beta Thalassemia Major | Completed | Ankara City Hospital Bilkent | 100 | 2024-10-20 | 2026-03-20 | |
| Elastography vs Iron Regulators in the Diagnosis of Hepatic Fibrosis- Iron Overload in Children With Beta- Thalassemia Serum ferritin, Serum hepcidin - Liver Fibrosis, Beta Thalassemia Major | Completed | Tanta University | 100 | 2024-09-12 | 2025-09-04 | |
| Neurodegenerative Diseases Progression Markers (MARKERS-NDD) Observation - Neurodegenerative Diseases, Parkinson Disease | Recruiting | Casa di Cura San Raffaele Cassino | 600 | 2024-09-09 | 2026-09-02 | |
| Infectious and Non-infectious Lower Respiratory Diseases in Children With Down Syndrome Followed in Pediatric Pulmonology Consultations in Ile-de-France lower respiratory tract disease - Down Syndrome | Completed | Centre Hospitalier Sud Francilien | 108 | 2024-03-28 | 2024-08-15 | |
| Fully Automated High-Throughput Quantitative MRI of the Liver Non-contrast MRI with novel MRI software - Healthy, Iron Overload | Recruiting | University of Wisconsin, Madison | 204 | 2023-10-16 | 2026-09-16 | |
| Leflunomide for Idiopathic Pulmonary Hemosiderosis in Children Leflunomide, Steroid Drug - Idiopathic Pulmonary Hemosiderosis, Leflunomide | Phase 1 / Phase 2 | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 34 | 2023-06-01 | 2023-07-10 |
| Analysis of the Effect of Iron Supplements on Iron Deficiency Anemia in Pregnancy Niferex - Iron Deficiency Anemia of Pregnancy, Iron Storage Disease | Phase 4 | Unknown | Qianfoshan Hospital | 452 | 2023-03-28 | 2023-04-07 |
| Quality and Biologic Characteristics of Red Blood Concentrates Obtained From Individuals With Elevated Ferritin. Venipuncture - Hereditary Hemochromatosis, Hyperferritinemia | Not applicable | Unknown | Interregionale Blutspende SRK | 100 | 2023-01-18 | 2023-02-23 |
| Heme and Non-heme Iron Intakes, Gut Microbiota, and Influence on Host Iron Absorption Anemia, Iron Deficiency, Iron Overload | Active not recruiting | Cornell University | 120 | 2023-01-15 | 2026-10-23 | |
| Long-term Clinical Study of CN128 in Thalassemia With Sever Liver Iron Overloaded Patients CN128 Tablets - Thalassemia, Iron Overload | Phase 2 | Completed | Hangzhou Zede Pharma-Tech Co., Ltd. | 16 | 2022-06-13 | 2025-03-14 |
| Inhibitory Effect of a Polyphenol Supplement on Dietary Iron Absorption in Adults with Thalassemia Meal matrix with polyphenol supplement (PPS), Meal matrix with placebo, No meal matrix with PPS - Thalassemia, Iron Overload | Not applicable | Completed | Swiss Federal Institute of Technology | 20 | 2022-06-01 | 2025-03-05 |
| A Study to Evaluate BBI-001 in Hereditary Haemochromatosis (HH) Patients and Iron Deficient Volunteers BBI-001, Original Fibre Metamucil - Hereditary Hemochromatosis | Phase 1 | Terminated | Bond Biosciences | 24 | 2022-03-28 | 2023-08-02 |
| MRI QSM Imaging for Iron Overload Magnetic Resonance Imaging (MRI)-based Quantitative Susceptibility Mapping (QSM) - Hemochromatosis, Iron Overload | Completed | University of Wisconsin, Madison | 63 | 2022-01-18 | 2024-05-09 |
Showing 20 of 185. Sign in to see all of them.
Hemochromatosis (54) · Thalassemia (37) · beta-Thalassemia (31) · Anemia, Sickle Cell (20) · Myelodysplastic Syndromes (16) · Hemosiderosis (14) · Anemia (7) · Hematologic Diseases (7) · Anemia, Iron-Deficiency (6) · Liver Cirrhosis (6) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (5) · Anemia, Aplastic (4) · Fatty Liver (4) · Leukemia, Myeloid, Acute (4)
Nutritional and Metabolic Diseases (185) · Metabolic Diseases (184) · Iron Metabolism Disorders (183) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (117) · Genetic Diseases, Inborn (116) · Hemic and Lymphatic Diseases (95) · Hematologic Diseases (88) · Anemia (75) · Anemia, Hemolytic, Congenital (70) · Anemia, Hemolytic (68) · Hemoglobinopathies (68) · Metabolism, Inborn Errors (54) · Metal Metabolism, Inborn Errors (54) · Thalassemia (21)
Deferasirox (43) · Deferoxamine (18) · Deferiprone (16) · Phlebotomy (14) · Magnetic Resonance Spectroscopy (3) · SP-420 (3) · 4,5-dihydro-2-(2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl)-4-methyl-4-thiazolecarboxylic acid (2) · Amlodipine (2) · Bloodletting (2) · Chelating Agents (2) · Hydroxyurea (2) · Iron Chelating Agents (2) · Long Interspersed Nucleotide Elements (2) · Magnetic Resonance Imaging (2) · ferrous sulfate (2)
Novartis Pharmaceuticals (31) · Rennes University Hospital (14) · ApoPharma (6) · HaEmek Medical Center, Israel (6) · National Heart, Lung, and Blood Institute (NHLBI) (5) · St. Jude Children's Research Hospital (4) · University of Wisconsin, Madison (4) · Assistance Publique - Hôpitaux de Paris (3) · Children's Hospital Los Angeles (3) · Shire (3) · University Hospital, Lille (3) · Bond Biosciences (2) · CSL Behring (2) · Cornell University (2) · Dana-Farber Cancer Institute (2)
United States (68) · France (32) · Italy (25) · Canada (19) · Egypt (14) · United Kingdom (14) · Turkey (Türkiye) (13) · Lebanon (10) · Thailand (10) · Israel (9) · Australia (8) · Germany (8) · Spain (8) · Belgium (7) · China (7)
Ariel Koren, MD (4) · Jane Hankins, MD, MS (3) · Bruno Laviolle, MD, PhD (2) · Carina Levin, MD (2) · Curtis Scribner, MD (2) · Eric Bellissant, MD, PhD (2) · Eva Rombout, MD (2) · Janet Kwiatkowski, MD (2) · John C Wood, MD, PhD (2) · Philippe Armand, MD, PhD (2) · Ahmed F Mahmoud Hussein, MS.c (1) · Alan R Cohen, MD (1)
PMID 37975597, PMID 29287521, PMID 15615854, PMID 15891110, PMID 17233848, PMID 17951527, PMID 17959863, PMID 18055982, PMID 18351337, PMID 19721001, PMID 19863539, PMID 20421452, PMID 20424435, PMID 20658587, PMID 20712782, PMID 20921906, PMID 20977930, PMID 21128750, PMID 21173101, PMID 21393329, PMID 21585237, PMID 21628399, PMID 21791473, PMID 21826782, PMID 21848963, PMID 22144108, PMID 22180427, PMID 22251482, PMID 22318199, PMID 22547607, PMID 22609885, PMID 2265118, PMID 23073603, PMID 23151373, PMID 23154940, PMID 23441892, PMID 23553596, PMID 23637051, PMID 23801540, PMID 23861242, PMID 24251381, PMID 24385534, PMID 24452753, PMID 24914136, PMID 24916507, PMID 24997153, PMID 25197009, PMID 25199788, PMID 25204541, PMID 25212456
2016 (2), 2014 (1), 2023 (1), 2025 (1), R01DK055463 (1), R01DK088988 (1), R01DK100651 (1), R01DK116126 (1), R01DK117354 (1), R01DK122216 (1), R01EB031886 (1), R01HL042814 (1), R01HL061428 (1), R15HL058203 (1), U01HL065232 (1)