4 recruiting, 3 completed, 3 terminated, 1 unknown. 11 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 11 | Recruiting 4, Completed 3, Terminated 3, Unknown 1 |
Follow Amyloidosis: new trials by email Literature Review of Amyloidosis trials Research Report on Amyloidosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis Acoramidis (AG10) oral tablet - Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM), Amyloidosis | Phase 4 | Recruiting | Eidos Therapeutics, a BridgeBio company | 150 | 2026-07-01 | 2026-07-29 |
| Enavogliflozin for the Management of Patients With Amyloid CardiomyopaThy Enavogliflozin 0.3mg, Placebo - Amyloid Cardiomyopathy | Phase 4 | Recruiting | Seoul St. Mary's Hospital | 68 | 2026-01-06 | 2026-06-18 |
| To Evaluate the Efficacy and Safety of Tafamidis Meglumine Soft Capsules in the Treatment of Adult Patients With Transthyretin Amyloid Polyneuropathy Tafamidis Meglumine Soft Capsules - Transthyretin Amyloid Polyneuropathy | Phase 4 | Recruiting | Qilu Pharmaceutical Co., Ltd. | 15 | 2025-06-19 | 2025-07-30 |
| N-of-1 for Beta-Blockers in Cardiac Amyloidosis Beta blocker - Cardiac Amyloidosis, Heart Diseases | Phase 4 | Completed | Weill Medical College of Cornell University | 14 | 2024-01-31 | 2026-07-29 |
| Ultrasound Therapy In Cardiac Amyloidosis Sonotherapy - Amyloidosis Cardiac | Phase 4 | Recruiting | Brigham and Women's Hospital | 70 | 2023-08-31 | 2026-08-21 |
| The Effect Of Tafamidis Meglumine In Transthyretin Amyloid Polyneuropathy Patients tafamidis meglumine - Transthyretin Amyloid Polyneuropathy (ATTR-PN) | Phase 4 | Completed | Pfizer | 15 | 2021-04-28 | 2024-03-12 |
| A Study to Characterize Adverse Events Occurring Within One Day of TEGSEDI Administration to Adult Participants With hATTR-PN TEGSEDI - Hereditary Transthyretin Amyloidosis With Polyneuropthy | Phase 4 | Terminated | Akcea Therapeutics | 8 | 2021-01-21 | 2025-04-10 |
| Cardiac Uptake of 18F Florbetapir in Patients Undergoing Chemotherapy F18 Florbetapir (amyvid) cardiac PET/CT imaging - Cardiac Amyloidosis | Phase 4 | Terminated | Medical College of Wisconsin | 4 | 2020-10-01 | 2026-07-16 |
| Comparison of BTD and BCD Based Regimens in the Treatment of AL Amyloidosis Thalidomide, Cyclophosphamide - Immunoglobulin Light-Chain Amyloidosis | Phase 4 | Unknown | Guangdong Provincial People's Hospital | 70 | 2020-01-01 | 2020-11-03 |
| The Role of F-18 Florbetapir in the Early Detection of Cardiac Amyloidosis F-18 florbetapir - Cardiac Amyloidosis | Phase 4 | Terminated | The Cleveland Clinic | 12 | 2017-01-01 | 2021-07-27 |
| Imaging Cardiac Amyloidosis: A Pilot Study Using F-18 Florbetapir Positron Emission Tomography F-18 florbetapir PET - Cardiac Amyloidosis | Phase 4 | Completed | Brigham and Women's Hospital | 23 | 2013-03-23 | 2025-11-20 |
Amyloid Neuropathies, Familial (9) · Amyloidosis, Hereditary, Transthyretin-Related (2) · Alzheimer Disease (1) · Cardiomyopathies (1) · Disease (1) · Heart Diseases (1) · Heart Failure (1) · Immunoglobulin Light-chain Amyloidosis (1)
Metabolic Diseases (11) · Nutritional and Metabolic Diseases (11) · Proteostasis Deficiencies (11) · Amyloid Neuropathies (9) · Amyloidosis, Familial (9) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (9) · Genetic Diseases, Inborn (9) · Heredodegenerative Disorders, Nervous System (9) · Metabolism, Inborn Errors (9) · Nervous System Diseases (9) · Neurodegenerative Diseases (9) · Neuromuscular Diseases (9) · Peripheral Nervous System Diseases (9) · Cardiovascular Diseases (2)
florbetapir (2) · Adrenergic beta-Antagonists (1) · Bortezomib (1) · Cyclophosphamide (1) · Enavogliflozin (1) · Inotersen (1) · Tablets (1) · Thalidomide (1) · attruby (1) · tafamidis (1)
Brigham and Women's Hospital (2) · Akcea Therapeutics (1) · Eidos Therapeutics, a BridgeBio company (1) · Guangdong Provincial People's Hospital (1) · Medical College of Wisconsin (1) · Pfizer (1) · Qilu Pharmaceutical Co., Ltd. (1) · Seoul St. Mary's Hospital (1) · The Cleveland Clinic (1) · Weill Medical College of Cornell University (1)
United States (7) · China (3) · Canada (1) · South Korea (1)
Chris Mueller, MD (1) · Jong-Chan Youn, MD, PhD (1) · Parag Goyal, MD, MSc (1) · Sharmila Dorbala, MBBS, MPH (1) · Sharmila Dorbala, MD (1) · Steven Nissen, MD (1) · Wael Jaber, MD (1) · Wenjian Wang, PhD (1)
PMID 24841414, PMID 37621153, PMID 38866445
R24AG064025 (1)