38 completed, 22 recruiting, 19 unknown, 9 not yet recruiting. 100 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 100 | Completed 38, Recruiting 22, Unknown 19, Not yet recruiting 9, Withdrawn 6, Terminated 3, Active not recruiting 2, Enrolling by invitation 1 |
Follow Amyloidosis: new trials by email Literature Review of Amyloidosis trials Research Report on Amyloidosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Evaluation of Subcutaneous Administration of Daratumumab by the FreedomEDGE® Infusion System Subcutaneous Daratumumab Administration Using FreedomEDGE® - Multiple Myeloma or Amyloidosis | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 100 | 2026-10-01 | 2026-07-23 |
| Early Detection of Amyloidosis in Monoclonal Gammopathy Using Nuclear Medicine Imaging ¹⁸F-florbetaben - Monoclonal Gammopathy, Monoclonal Gammopathy of Undetermined Significance (MGUS) | Not applicable | Not yet recruiting | University of Zurich | 50 | 2026-10-01 | 2026-06-03 |
| Application of Digital Twins' Technology in Patients Who Had a Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During the Secondary Prevention Phase: A Proof of Concept Using a Randomized Control Trial (Clinical Study 6, STRATIF-AI Project) AI, healthy dialogue - Stroke, Moyamoya Disease | Not applicable | Recruiting | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 20 | 2026-10-01 | 2026-08-28 |
| Impact of a Cardiac Rehabilitation Program on Patients With Cardiac Amyloidosis Cardiac Rehabilitation Program - Amyloidosis | Not applicable | Recruiting | University Hospital, Montpellier | 40 | 2026-09-23 | 2026-10-08 |
| Individualized Exercise Training in Cardiac Amyloidosis Exercise Intervention, Physical Activity Handout - Cardiac Amyloidosis | Not applicable | Not yet recruiting | Oregon Health and Science University | 60 | 2026-09-15 | 2026-09-23 |
| Prevalence of Cardiac Thrombi in Cardiac Amyloidosis Cardiac CT scan with contrast - Cardiac Amyloidosis | Not applicable | Recruiting | Centre Hospitalier Universitaire Dijon | 200 | 2026-09-07 | 2026-09-17 |
| Detection of Cardiac Amyloidosis Using Right Ventricular Sensing Amplitude in Patients With Left Ventricular Hypertrophy Cardiac amyloidosis screening during CIED implantation - Cardiac Amyloidosis, Left Ventricular Hypertrophy | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 242 | 2026-09-01 | 2026-07-29 |
| AI-based Echocardiography for Detection of Cardiac Amyloidosis AI-based echocardiogram - Cardiac Amyloidosis, Heart Failure With Preserved Ejection Fraction (HFPEF) | Not applicable | Not yet recruiting | Germans Trias i Pujol Hospital | 200 | 2026-07-01 | 2026-06-12 |
| Early Screening for Cardiac Amyloid Using a History of Bilateral Carpal Tunnel Syndrome Technetium-99m Pyrophosphate (Tc-99m PYP) Scan - Bilateral Carpal Tunnel Syndrome (Diagnosis), Cardiac Amyloidosis | Not applicable | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 139 | 2026-07-01 | 2026-05-12 |
| Evaluation of Skin Tests in Biotherapy Allergies Drug skin tests (investigating hypersensitivity to a biotherapy) - Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck, Melanoma Neoplasms | Not applicable | Recruiting | University Hospital, Angers | 70 | 2026-06-17 | 2026-06-18 |
| Early Detection of Concealed Cardiac Amyloidosis Using AI-ECG and CT-Derived Extracellular Volume in Patients With Atrial Fibrillation AI-ECG analysis, CT-ECV analysis, Atrial fibrillation treatment - Atrial Fibrillation (AF), Cardiac Amyloidosis | Not applicable | Not yet recruiting | Samsung Medical Center | 500 | 2026-05-01 | 2026-05-05 |
| EFICAC-TTR Trial: Exercise and Nutritional Supplementation in Transthyretin Cardiac Amyloidosis Home-Based Multicomponent Exercise Program, Microcrystalline Cellulose Control Supplementation, Creatine and HMB Supplementation - Transthyretin Cardiac Amyloidosis | Not applicable | Completed | Universidad de Burgos | 47 | 2026-02-03 | 2026-09-25 |
| Increased Pacemaker Lower Rate in ATTR Cardiac Amyloidosis Increasing the pacemaker lower rate, Standard setting - Cardiac Amyloidosis, Pacemaker | Not applicable | Not yet recruiting | Region Skane | 34 | 2026-02-01 | 2026-02-17 |
| A Clinical Study on Minimal Residual Disease in Patients With Systemic Light Chain Amyloidosis First-Line Dara-BorCyD Treatment - Light Chain (AL) Amyloidosis, MRD | Not applicable | Recruiting | Peking University First Hospital | 50 | 2025-12-15 | 2026-09-16 |
| Multimodality Cardiac Imaging for Disease Progression in ATTR-CM FAPI tracer - Amyloidosis Cardiac | Not applicable | Recruiting | Dominik Benz | 50 | 2025-10-20 | 2025-12-09 |
| Elevated Rate Pacing of Cardiac Amyloidosis Pacemaker Rate - Cardiac Amyloidosis, Pacemaker | Not applicable | Recruiting | University of Minnesota | 10 | 2025-10-10 | 2026-10-13 |
| Prospective Study of Teclistamab in the Treatment of Systemic AL Amyloidosis Teclistamab (Tec) - AL Amyloidosis | Not applicable | Recruiting | Peking University People's Hospital | 20 | 2025-03-29 | 2025-04-24 |
| Exploratory Clinical Study on the Safety and Efficacy of Targeted BCMA Autologous CART Cell Injection in Subjects With Recurrent/Refractory Light Chain Amyloidosis BCMA CART - Light Chain Amyloidosis | Not applicable | Withdrawn | Beijing Boren Hospital | 2025-02-20 | 2026-10-13 | |
| BCMA/CD3 BiTE for RRAL or NDAL Amyloidosis With Insufficient Depth of Hematologic Response After Induction Therapy CM-336 BCMA/CD3 bispecific antibody - AL Amyloidosis | Not applicable | Withdrawn | Institute of Hematology & Blood Diseases Hospital, China | 2025-01-01 | 2026-04-29 | |
| PATHWAY-RCT: Preventing Admission To Hospital With Attr cardiomyopathY Telemonitoring service - Cardiac Amyloidosis | Not applicable | Recruiting | Richmond Research Institute | 320 | 2025-01-01 | 2026-06-16 |
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Amyloid Neuropathies, Familial (43) · Immunoglobulin Light-chain Amyloidosis (23) · Multiple Myeloma (14) · Leukemia, Lymphocytic, Chronic, B-Cell (11) · Heart Failure (9) · Hodgkin Disease (9) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (9) · Burkitt Lymphoma (8) · Leukemia, Myeloid, Acute (8) · Lymphoma, Follicular (8) · Lymphoma, Large B-Cell, Diffuse (8) · Lymphoma, Large-Cell, Anaplastic (8) · Lymphoma, Non-Hodgkin (8) · Lymphoma, T-Cell, Cutaneous (8)
Metabolic Diseases (100) · Nutritional and Metabolic Diseases (100) · Proteostasis Deficiencies (100) · Nervous System Diseases (60) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (53) · Neurodegenerative Diseases (48) · Neuromuscular Diseases (47) · Genetic Diseases, Inborn (46) · Peripheral Nervous System Diseases (46) · Metabolism, Inborn Errors (45) · Amyloidosis, Familial (43) · Heredodegenerative Disorders, Nervous System (43) · Amyloid Neuropathies (42) · Cardiovascular Diseases (40)
Dexamethasone (5) · Bortezomib (4) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (3) · Whole-Body Irradiation (3) · daratumumab (3) · Blood Specimen Collection (2) · Cyclophosphamide (2) · Cyclosporine (2) · Exercise (2) · Melphalan (2) · Mycophenolic Acid (2) · Peripheral Blood Stem Cell Transplantation (2) · Tomography, Emission-Computed, Single-Photon (2) · fludarabine phosphate (2) · pomalidomide (2)
University Hospital, Toulouse (4) · Assistance Publique - Hôpitaux de Paris (3) · Massachusetts General Hospital (3) · University Hospital Center of Martinique (3) · Wake Forest University Health Sciences (3) · Brigham and Women's Hospital (2) · Capital Medical University (2) · Fondazione IRCCS Policlinico San Matteo di Pavia (2) · Fred Hutchinson Cancer Center (2) · GCS Ramsay Santé pour l'Enseignement et la Recherche (2) · Mayo Clinic (2) · Stanford University (2) · Steen Hvitfeldt Poulsen (2) · Tel-Aviv Sourasky Medical Center (2) · Aarhus University Hospital Skejby (1)
United States (24) · France (23) · China (10) · Italy (9) · Denmark (5) · Switzerland (4) · Belgium (3) · Germany (3) · Martinique (3) · Brazil (2) · Guadeloupe (2) · Israel (2) · South Korea (2) · Spain (2) · Canada (1)
Alberto M. Marrra, Md,PhD (1) · Alessandro Flavio Ferri (1) · Amal Kaddoumi, PhD (1) · Angela Dispenzieri, MD (1) · Ann Woolfrey (1) · Anthony A Bavry, MD MPH (1) · Anthony J Windebank, MD (1) · Aprille Seidel, PhD (1) · Charles Day, MD (1) · Christian Jung, Prof. Dr. (1) · Dario Roccatello (1) · David Maloney (1) · Dimitri Renard, MD (1) · Dominik C Benz, MD (1)
PMID 25803389, PMID 33825853, PMID 15365071, PMID 18698002, PMID 20103757, PMID 21732836, PMID 22331188, PMID 23358983, PMID 23716538, PMID 25027514, PMID 25580702, PMID 25950872, PMID 26117060, PMID 26250487, PMID 27206819, PMID 27618855, PMID 28279033, PMID 28570698, PMID 28987521, PMID 29052438, PMID 30592475, PMID 31081853, PMID 31151984, PMID 31171094, PMID 31958082, PMID 32394598, PMID 32417333, PMID 32499241, PMID 34000646, PMID 34503349, PMID 34922860, PMID 35972776, PMID 36082269, PMID 37422895, PMID 37620982, PMID 38228908, PMID 38522901, PMID 38638999, PMID 38751455, PMID 38873265, PMID 39001736, PMID 40392565, PMID 40518108, PMID 40586114, PMID 40938234, PMID 41073834, PMID 41213043, PMID 41894682
P30CA015704 (2), 2015 (1), 2017 (1), 2018 (1), 2025 (1), P01CA018029 (1), P30CA016056 (1), P30CA033572 (1), R01AG056351 (1), R01HL130563 (1)