Acute Undifferentiated Leukemia: Clinical Trials

14 trials for Acute Undifferentiated Leukemia, newest first

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7 completed, 2 active not recruiting, 2 recruiting, 2 terminated. 14 Phase 2, 5 Phase 1.

By phase and status

PhaseTrialsStatus
Phase 214Completed 7, Active not recruiting 2, Recruiting 2, Terminated 2, Not yet recruiting 1
Phase 15Completed 2, Recruiting 2, Active not recruiting 1

Follow Acute Undifferentiated Leukemia: new trials by email Literature Review of Acute Undifferentiated Leukemia trials Research Report on Acute Undifferentiated Leukemia

Trials (filtered) newest first · largest first

All 14 trials

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

TrialPhaseStatusSponsorEnrollmentStartUpdated
Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic Syndrome
Allogeneic CD34+-enriched and CD45RA-depleted PBSCs, Biospecimen Collection, Bone Marrow Aspiration - Acute Biphenotypic Leukemia, Acute Leukemia
Phase 2Not yet recruitingFred Hutchinson Cancer Center522027-01-012026-09-14
Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse
Decitabine, Bone Marrow Aspiration, Bone Marrow Biopsy - Acute Myeloid Leukemia, Acute Undifferentiated Leukemia
Phase 1 / Phase 2RecruitingFred Hutchinson Cancer Center362025-09-232026-05-15
A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies
Ossium HPC Marrow, Bone Marrow Transplant, Pre-transplant conditioning - Myeloablative (MAC), Pre-transplant conditioning - Reduced Intensity (RIC) - Acute Leukemia, Acute Lymphoblastic Leukemia
Phase 1 / Phase 2Active not recruitingOssium Health, Inc.122024-08-162026-09-10
Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)
Orca-Q - Acute Myeloid Leukemia, Acute Lymphoid Leukemia
Phase 1 / Phase 2RecruitingUniversity of Florida402022-08-162026-09-01
Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant
Total-Body Irradiation, Thiotepa, Fludarabine - Acute Biphenotypic Leukemia, Acute Leukemia
Phase 2Active not recruitingFred Hutchinson Cancer Center452019-08-292026-09-25
Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD
Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Fludarabine Phosphate - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia
Phase 2CompletedFred Hutchinson Cancer Center842015-03-232026-06-01
Clofarabine, Idarubicin, Cytarabine, Vincristine Sulfate, and Dexamethasone in Treating Patients With Newly Diagnosed or Relapsed Mixed Phenotype Acute Leukemia
Clofarabine, Cytarabine, Dexamethasone - Acute Bilineal Leukemia, Acute Biphenotypic Leukemia
Phase 2CompletedM.D. Anderson Cancer Center162014-10-272024-03-22
Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children
Allogeneic Hematopoietic Stem Cell Transplantation, Fludarabine Phosphate, Laboratory Biomarker Analysis - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia
Phase 2CompletedFred Hutchinson Cancer Center202014-04-102024-03-12
Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies
deferasirox, laboratory biomarker analysis, enzyme-linked immunosorbent assay - Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Phase 2CompletedWake Forest University Health Sciences162011-01-012018-09-07
Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies
Cyclophosphamide, Filgrastim, Fludarabine Phosphate - Acute Biphenotypic Leukemia, Acute Erythroid Leukemia in Remission
Phase 2TerminatedFred Hutchinson Cancer Center462010-05-192023-01-23
Sunitinib in Treating Patients With Idiopathic Myelofibrosis
sunitinib malate - Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia
Phase 2TerminatedNational Cancer Institute (NCI)142006-09-012014-05-28
Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer
alemtuzumab, total-body irradiation, fludarabine phosphate - Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Phase 2CompletedFred Hutchinson Cancer Center122005-03-012017-05-30
Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia
allopurinol, cyclophosphamide, daunorubicin hydrochloride - Acute Undifferentiated Leukemia, B-cell Adult Acute Lymphoblastic Leukemia
Phase 1 / Phase 2CompletedNational Cancer Institute (NCI)3022003-06-012022-05-03
Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer
total-body irradiation, fludarabine phosphate, cyclosporine - Acute Undifferentiated Leukemia, Adult Nasal Type Extranodal NK/T-cell Lymphoma
Phase 1 / Phase 2CompletedFred Hutchinson Cancer Center212000-05-012020-01-21

Narrower conditions

Leukemia, Biphenotypic, Acute (14)  ·  Precursor Cell Lymphoblastic Leukemia-Lymphoma (11)  ·  Leukemia, Myeloid, Acute (10)  ·  Burkitt Lymphoma (6)  ·  Leukemia, Mast-Cell (6)  ·  Hodgkin Disease (5)  ·  Leukemia, Lymphocytic, Chronic, B-Cell (4)  ·  Leukemia, Myelogenous, Chronic, BCR-ABL Positive (4)  ·  Leukemia, Myeloid, Accelerated Phase (4)  ·  Leukemia, Myelomonocytic, Chronic (4)  ·  Lymphoma, B-Cell, Marginal Zone (4)  ·  Lymphoma, Follicular (4)  ·  Lymphoma, Large-Cell, Anaplastic (4)  ·  Lymphoma, Mantle-Cell (4)  ·  Lymphoma, T-Cell, Cutaneous (4)

Broader conditions

Hemic and Lymphatic Diseases (14)  ·  Immune System Diseases (14)  ·  Immunoproliferative Disorders (14)  ·  Leukemia, Lymphoid (14)  ·  Lymphatic Diseases (14)  ·  Lymphoproliferative Disorders (14)  ·  Neoplasms (14)  ·  Neoplasms by Histologic Type (14)  ·  Hematologic Diseases (13)  ·  Leukemia (13)  ·  Bone Marrow Diseases (12)  ·  Chronic Disease (10)  ·  Disease Attributes (10)  ·  Leukemia, Myeloid (10)  ·  Pathologic Processes (10)

Interventions

Whole-Body Irradiation (8)  ·  fludarabine phosphate (7)  ·  Cyclophosphamide (6)  ·  Mycophenolic Acid (5)  ·  Peripheral Blood Stem Cell Transplantation (5)  ·  Filgrastim (4)  ·  Methotrexate (4)  ·  Tacrolimus (4)  ·  Cytarabine (3)  ·  Thiotepa (3)  ·  fludarabine (3)  ·  Alemtuzumab (2)  ·  Biopsy (2)  ·  Bone Marrow Transplantation (2)  ·  Cyclosporine (2)

Sponsors

Fred Hutchinson Cancer Center (8)  ·  National Cancer Institute (NCI) (2)  ·  M.D. Anderson Cancer Center (1)  ·  Ossium Health, Inc. (1)  ·  University of Florida (1)  ·  Wake Forest University Health Sciences (1)

Countries

United States (14)  ·  Italy (2)

Top investigators

Marie Bleakley (3)  ·  Brenda Sandmaier (1)  ·  David Maloney (1)  ·  Elias Jabbour (1)  ·  Jordan Milner, MD (1)  ·  Mary Ann Knovich, MD (1)  ·  Naveed Ali, MD (1)  ·  Phuong Vo, MD (1)  ·  Rachel B. Salit (1)  ·  Srdan Verstovsek (1)  ·  Wendy Stock (1)

Results publications

PMID 35007144, PMID 32499241, PMID 33049057

NIH funding

P01CA018029 (4), P30CA015704 (3), R01HL121568 (2), K23CA154532 (1), N01CM62202 (1), P01CA078902 (1), U10CA031946 (1)